Program

Causal Mechanistic Flows with regulons in program Pr-71

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
LAMA1down-regulatesPBX1activatesR-21150.3574216Pr-71
NFKB2down-regulatesPBX1activatesR-21150.3574216Pr-71
RNASeq_FGFR3_Callup-regulatesPBX1activatesR-21150.3574216Pr-71
t(4;14)up-regulatesPBX1activatesR-21150.3574216Pr-71
RYR1down-regulatesPBX1activatesR-21150.3574216Pr-71
amp1qup-regulatesPBX1activatesR-21150.3574216Pr-71
del13up-regulatesPBX1activatesR-21150.3574216Pr-71
BRAFdown-regulatesPAX6repressesR-15571.876617Pr-71
t(11;14)down-regulatesPAX6repressesR-15571.876617Pr-71
RNASeq_FGFR3_Calldown-regulatesPAX6repressesR-15571.876617Pr-71
t(14;16)down-regulatesPAX6repressesR-15571.876617Pr-71
t(4;14)down-regulatesPAX6repressesR-15571.876617Pr-71
RYR1up-regulatesPAX6repressesR-15571.876617Pr-71
amp1qdown-regulatesPAX6repressesR-15571.876617Pr-71
del13down-regulatesPAX6repressesR-15571.876617Pr-71
t(11;14)_cytogeneticdown-regulatesPAX6repressesR-15571.876617Pr-71
DIS3up-regulatesENSG00000128652activatesR-22615.4717311Pr-71
FGFR3up-regulatesENSG00000128652activatesR-22615.4717311Pr-71
MAXup-regulatesENSG00000128652activatesR-22615.4717311Pr-71
PRKD2up-regulatesENSG00000128652activatesR-22615.4717311Pr-71
RNASeq_FGFR3_Callup-regulatesENSG00000128652activatesR-22615.4717311Pr-71
t(4;14)up-regulatesENSG00000128652activatesR-22615.4717311Pr-71
amp1qup-regulatesENSG00000128652activatesR-22615.4717311Pr-71
del13up-regulatesENSG00000128652activatesR-22615.4717311Pr-71
t(4;14)_cytogeneticup-regulatesENSG00000128652activatesR-22615.4717311Pr-71
IRF4up-regulatesRARAactivatesR-1526.6292419Pr-71
t(11;14)up-regulatesRARAactivatesR-1526.6292419Pr-71
del13up-regulatesRARAactivatesR-1526.6292419Pr-71
t(11;14)_cytogeneticup-regulatesRARAactivatesR-1526.6292419Pr-71
t(11;14)up-regulatesFOXP1activatesR-31226.7878734Pr-71
t(14;16)up-regulatesFOXP1activatesR-31226.7878734Pr-71
amp1qup-regulatesFOXP1activatesR-31226.7878734Pr-71
del13up-regulatesFOXP1activatesR-31226.7878734Pr-71
del1pup-regulatesFOXP1activatesR-31226.7878734Pr-71
t(11;14)_cytogeneticup-regulatesFOXP1activatesR-31226.7878734Pr-71
BRAFup-regulatesFOXJ3activatesR-28757.1540936Pr-71
t(11;14)up-regulatesFOXJ3activatesR-28757.1540936Pr-71
RNASeq_FGFR3_Callup-regulatesFOXJ3activatesR-28757.1540936Pr-71
t(4;14)up-regulatesFOXJ3activatesR-28757.1540936Pr-71
amp1qup-regulatesFOXJ3activatesR-28757.1540936Pr-71
del13up-regulatesFOXJ3activatesR-28757.1540936Pr-71
t(11;14)_cytogeneticup-regulatesFOXJ3activatesR-28757.1540936Pr-71
DIS3down-regulatesSRFrepressesR-17807.2086735Pr-71
DNAH10down-regulatesSRFrepressesR-17807.2086735Pr-71
FAM46Cup-regulatesSRFrepressesR-17807.2086735Pr-71
FAT3down-regulatesSRFrepressesR-17807.2086735Pr-71
FRAS1down-regulatesSRFrepressesR-17807.2086735Pr-71
IRF4down-regulatesSRFrepressesR-17807.2086735Pr-71
PRKD2down-regulatesSRFrepressesR-17807.2086735Pr-71
t(11;14)down-regulatesSRFrepressesR-17807.2086735Pr-71
RNASeq_FGFR3_Calldown-regulatesSRFrepressesR-17807.2086735Pr-71
t(14;16)down-regulatesSRFrepressesR-17807.2086735Pr-71
t(4;14)down-regulatesSRFrepressesR-17807.2086735Pr-71
TP53down-regulatesSRFrepressesR-17807.2086735Pr-71
t(11;14)up-regulatesFOXJ2activatesR-14267.4414232Pr-71
t(14;16)up-regulatesFOXJ2activatesR-14267.4414232Pr-71
t(4;14)up-regulatesFOXJ2activatesR-14267.4414232Pr-71
amp1qup-regulatesFOXJ2activatesR-14267.4414232Pr-71
del13up-regulatesFOXJ2activatesR-14267.4414232Pr-71
MAXup-regulatesTCF3activatesR-20487.4434739Pr-71
NFKB2down-regulatesTCF3activatesR-20487.4434739Pr-71
ZNF208up-regulatesTCF3activatesR-20487.4434739Pr-71
ATMup-regulatesENSG00000176399activatesR-10717.7975910Pr-71
DCHS1up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
DIS3up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
FAM46Cdown-regulatesENSG00000176399activatesR-10717.7975910Pr-71
FGFR3up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
IRF4up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
PRKD2up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
t(11;14)up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
RNASeq_FGFR3_Callup-regulatesENSG00000176399activatesR-10717.7975910Pr-71
t(14;16)up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
t(4;14)up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
del13up-regulatesENSG00000176399activatesR-10717.7975910Pr-71
t(11;14)_cytogeneticup-regulatesENSG00000176399activatesR-10717.7975910Pr-71
t(4;14)_cytogeneticup-regulatesENSG00000176399activatesR-10717.7975910Pr-71
FAT3up-regulatesE2F8activatesR-16288.733217Pr-71
MAXup-regulatesE2F8activatesR-16288.733217Pr-71
t(11;14)up-regulatesE2F8activatesR-16288.733217Pr-71
t(14;16)up-regulatesE2F8activatesR-16288.733217Pr-71
TP53up-regulatesE2F8activatesR-16288.733217Pr-71
ZNF208up-regulatesE2F8activatesR-16288.733217Pr-71

Regulons in program Pr-71

Regulon Cox Hazard Ratio # genes # causal flows
R-21150.35742167
R-15571.8766179
R-22615.47173119
R-1526.62924194
R-31226.78787346
R-28757.15409367
R-17807.208673512
R-14267.44142325
R-20487.44347393
R-10717.797591014
R-16288.7332176

Genes in program Pr-71

EnsEMBL IdEntrez IdPreferred
ENSG00000179222 9500MAGED1
ENSG00000219200 440400RNASEK

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions