Program

Causal Mechanistic Flows with regulons in program Pr-63

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
IRF4down-regulatesSPDEFrepressesR-19741.598086Pr-63
t(11;14)down-regulatesSPDEFrepressesR-19741.598086Pr-63
TP53down-regulatesSPDEFrepressesR-19741.598086Pr-63
amp1qup-regulatesSPDEFrepressesR-19741.598086Pr-63
del13up-regulatesSPDEFrepressesR-19741.598086Pr-63
t(4;14)up-regulatesFOXK1repressesR-12081.869768Pr-63
amp1qup-regulatesFOXK1repressesR-12081.869768Pr-63
del13up-regulatesFOXK1repressesR-12081.869768Pr-63
DIS3up-regulatesENSG00000165066activatesR-30823.327388Pr-63
IRF4up-regulatesENSG00000165066activatesR-30823.327388Pr-63
t(11;14)up-regulatesENSG00000165066activatesR-30823.327388Pr-63
t(14;16)down-regulatesENSG00000165066activatesR-30823.327388Pr-63
ROBO1down-regulatesENSG00000165066activatesR-30823.327388Pr-63
SP140down-regulatesENSG00000165066activatesR-30823.327388Pr-63
TP53up-regulatesENSG00000165066activatesR-30823.327388Pr-63
amp1qdown-regulatesENSG00000165066activatesR-30823.327388Pr-63
del13down-regulatesENSG00000165066activatesR-30823.327388Pr-63
t(11;14)_cytogeneticup-regulatesENSG00000165066activatesR-30823.327388Pr-63
DIS3up-regulatesZNF219activatesR-22144.2639710Pr-63
DSTdown-regulatesZNF219activatesR-22144.2639710Pr-63
IRF4up-regulatesZNF219activatesR-22144.2639710Pr-63
KIAA1244down-regulatesZNF219activatesR-22144.2639710Pr-63
KRASup-regulatesZNF219activatesR-22144.2639710Pr-63
PRKD2up-regulatesZNF219activatesR-22144.2639710Pr-63
t(11;14)up-regulatesZNF219activatesR-22144.2639710Pr-63
RNASeq_FGFR3_Callup-regulatesZNF219activatesR-22144.2639710Pr-63
MYCdown-regulatesZNF219activatesR-22144.2639710Pr-63
t(4;14)up-regulatesZNF219activatesR-22144.2639710Pr-63
UBR4down-regulatesZNF219activatesR-22144.2639710Pr-63
t(11;14)_cytogeneticup-regulatesZNF219activatesR-22144.2639710Pr-63
t(4;14)_cytogeneticup-regulatesZNF219activatesR-22144.2639710Pr-63
DIS3down-regulatesSRFrepressesR-17854.5554824Pr-63
DNAH10down-regulatesSRFrepressesR-17854.5554824Pr-63
IRF4down-regulatesSRFrepressesR-17854.5554824Pr-63
MXRA5down-regulatesSRFrepressesR-17854.5554824Pr-63
PRKD2down-regulatesSRFrepressesR-17854.5554824Pr-63
t(11;14)down-regulatesSRFrepressesR-17854.5554824Pr-63
RNASeq_FGFR3_Calldown-regulatesSRFrepressesR-17854.5554824Pr-63
TP53down-regulatesSRFrepressesR-17854.5554824Pr-63
DIS3up-regulatesSP1activatesR-27224.5758823Pr-63
IRF4up-regulatesSP1activatesR-27224.5758823Pr-63
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27224.5758823Pr-63
t(4;14)_cytogeneticup-regulatesSP1activatesR-27224.5758823Pr-63
t(11;14)up-regulatesE2F1activatesR-21745.047257Pr-63
t(14;16)up-regulatesE2F1activatesR-21745.047257Pr-63
TP53up-regulatesE2F1activatesR-21745.047257Pr-63
ZNF462up-regulatesE2F1activatesR-21745.047257Pr-63
DSTdown-regulatesIRF7activatesR-10885.0848114Pr-63
NRASup-regulatesIRF7activatesR-10885.0848114Pr-63
ROBO1down-regulatesIRF7activatesR-10885.0848114Pr-63
TP53up-regulatesIRF7activatesR-10885.0848114Pr-63
TRAF3down-regulatesIRF7activatesR-10885.0848114Pr-63
amp1qdown-regulatesIRF7activatesR-10885.0848114Pr-63
del13down-regulatesIRF7activatesR-10885.0848114Pr-63
t(11;14)up-regulatesFOSactivatesR-21945.484476Pr-63
ROBO1down-regulatesFOSactivatesR-21945.484476Pr-63
amp1qdown-regulatesFOSactivatesR-21945.484476Pr-63
del13down-regulatesFOSactivatesR-21945.484476Pr-63
t(11;14)_cytogeneticup-regulatesFOSactivatesR-21945.484476Pr-63

Regulons in program Pr-63

Regulon Cox Hazard Ratio # genes # causal flows
R-19741.5980865
R-12081.8697683
R-30823.32738810
R-22144.263971013
R-17854.55548248
R-27224.57588234
R-21745.0472574
R-10885.08481147
R-21945.4844765

Genes in program Pr-63

EnsEMBL IdEntrez IdPreferred
ENSG00000204590 2794GNL1
ENSG00000216490 10437IFI30

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions