Program

Causal Mechanistic Flows with regulons in program Pr-32

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
LRP1Bdown-regulatesENSG00000245848activatesR-16452.2082316Pr-32
MAGI1down-regulatesENSG00000245848activatesR-16452.2082316Pr-32
MYH2down-regulatesENSG00000245848activatesR-16452.2082316Pr-32
NEBdown-regulatesENSG00000245848activatesR-16452.2082316Pr-32
t(11;14)up-regulatesENSG00000245848activatesR-16452.2082316Pr-32
TRAF3down-regulatesENSG00000245848activatesR-16452.2082316Pr-32
t(14;16)_cytogeneticdown-regulatesENSG00000245848activatesR-16452.2082316Pr-32
NEBup-regulatesPAX6repressesR-15502.2339112Pr-32
t(11;14)down-regulatesPAX6repressesR-15502.2339112Pr-32
SYNE1up-regulatesPAX6repressesR-15502.2339112Pr-32
MYH2down-regulatesCEBPDactivatesR-13092.340039Pr-32
t(11;14)up-regulatesCEBPDactivatesR-13092.340039Pr-32
t(4;14)down-regulatesCEBPDactivatesR-13092.340039Pr-32
TRAF3down-regulatesCEBPDactivatesR-13092.340039Pr-32
t(14;16)_cytogeneticdown-regulatesCEBPDactivatesR-13092.340039Pr-32
DNAH10up-regulatesSPIBactivatesR-6692.4337514Pr-32
LRP2down-regulatesRELactivatesR-12803.388416Pr-32
MAGI1down-regulatesRELactivatesR-12803.388416Pr-32
NEBdown-regulatesRELactivatesR-12803.388416Pr-32
PRKD2up-regulatesRELactivatesR-12803.388416Pr-32
t(11;14)up-regulatesRELactivatesR-12803.388416Pr-32
t(14;16)_cytogeneticdown-regulatesRELactivatesR-12803.388416Pr-32
COL6A5down-regulatesHLXactivatesR-2762-4.2924112Pr-32
FAT3down-regulatesHLXactivatesR-2762-4.2924112Pr-32
KDM3Bdown-regulatesHLXactivatesR-2762-4.2924112Pr-32
LRP2down-regulatesHLXactivatesR-2762-4.2924112Pr-32
MUC12down-regulatesHLXactivatesR-2762-4.2924112Pr-32
PCLOdown-regulatesHLXactivatesR-2762-4.2924112Pr-32
t(11;14)up-regulatesHLXactivatesR-2762-4.2924112Pr-32
MYCdown-regulatesHLXactivatesR-2762-4.2924112Pr-32
t(14;16)_cytogeneticdown-regulatesHLXactivatesR-2762-4.2924112Pr-32

Regulons in program Pr-32

Regulon Cox Hazard Ratio # genes # causal flows
R-16452.20823167
R-15502.23391123
R-13092.3400395
R-6692.43375141
R-12803.3884166
R-2762-4.29241129

Genes in program Pr-32

EnsEMBL IdEntrez IdPreferred
ENSG00000248919 100526740ATP5MF-PTCD1
ENSG00000251192 641339ZNF674
ENSG00000258659 53840TRIM34
ENSG00000123268 466ATF1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions