Program

Causal Mechanistic Flows with regulons in program Pr-27

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesZNF281activatesR-2493-0.9593137Pr-27
RNASeq_FGFR3_Callup-regulatesZNF281activatesR-2493-0.9593137Pr-27
t(4;14)up-regulatesZNF281activatesR-2493-0.9593137Pr-27
amp1qup-regulatesZNF281activatesR-2493-0.9593137Pr-27
del13up-regulatesZNF281activatesR-2493-0.9593137Pr-27
DNAH10down-regulatesFOXO3activatesR-2777-0.9828277Pr-27
HUWE1down-regulatesFOXO3activatesR-2777-0.9828277Pr-27
IRF4down-regulatesFOXO3activatesR-2777-0.9828277Pr-27
PRKD2down-regulatesFOXO3activatesR-2777-0.9828277Pr-27
t(11;14)down-regulatesFOXO3activatesR-2777-0.9828277Pr-27
TRAF3down-regulatesFOXO3activatesR-2777-0.9828277Pr-27
t(11;14)_cytogeneticdown-regulatesFOXO3activatesR-2777-0.9828277Pr-27
AHNAK2down-regulatesSRFactivatesR-1790-1.043798Pr-27
DNAH10down-regulatesSRFactivatesR-1790-1.043798Pr-27
MXRA5down-regulatesSRFactivatesR-1790-1.043798Pr-27
PRKD2down-regulatesSRFactivatesR-1790-1.043798Pr-27
t(11;14)down-regulatesSRFactivatesR-1790-1.043798Pr-27
MYCdown-regulatesSRFactivatesR-1790-1.043798Pr-27
TP53down-regulatesSRFactivatesR-1790-1.043798Pr-27
KDM3Bup-regulatesZNF143repressesR-2323-1.170166Pr-27
MYCup-regulatesZNF143repressesR-2323-1.170166Pr-27
AHNAK2down-regulatesRORAactivatesR-2279-1.269216Pr-27
KDM3Bdown-regulatesRORAactivatesR-2279-1.269216Pr-27
LTBup-regulatesRORAactivatesR-2279-1.269216Pr-27
del13up-regulatesRORAactivatesR-2279-1.269216Pr-27
AHNAK2down-regulatesEWSR1activatesR-2558-1.308147Pr-27
RNASeq_FGFR3_Callup-regulatesEWSR1activatesR-2558-1.308147Pr-27
t(14;16)up-regulatesEWSR1activatesR-2558-1.308147Pr-27
t(4;14)up-regulatesEWSR1activatesR-2558-1.308147Pr-27
amp1qup-regulatesEWSR1activatesR-2558-1.308147Pr-27
del13up-regulatesEWSR1activatesR-2558-1.308147Pr-27
AHNAK2down-regulatesMAFKactivatesR-2815-1.672286Pr-27
PTPRDdown-regulatesMAFKactivatesR-2815-1.672286Pr-27
amp1qup-regulatesMAFKactivatesR-2815-1.672286Pr-27
del13up-regulatesMAFKactivatesR-2815-1.672286Pr-27
AHNAK2down-regulatesNR3C1activatesR-3194-1.672286Pr-27
PRKD2down-regulatesNR3C1activatesR-3194-1.672286Pr-27
t(11;14)down-regulatesNR3C1activatesR-3194-1.672286Pr-27
t(14;16)up-regulatesNR3C1activatesR-3194-1.672286Pr-27
del13up-regulatesNR3C1activatesR-3194-1.672286Pr-27
t(11;14)_cytogeneticdown-regulatesNR3C1activatesR-3194-1.672286Pr-27

Regulons in program Pr-27

Regulon Cox Hazard Ratio # genes # causal flows
R-2493-0.95931375
R-2777-0.98282777
R-1790-1.0437987
R-2323-1.1701662
R-2279-1.2692164
R-2558-1.3081476
R-2815-1.6722864
R-3194-1.6722866

Genes in program Pr-27

EnsEMBL IdEntrez IdPreferred
ENSG00000187546 392636AGMO
ENSG00000187955
ENSG00000188820 441168CALHM6
ENSG00000196865 374354NHLRC2
ENSG00000197702
ENSG00000197959 26052DNM3
ENSG00000205726 6453ITSN1
ENSG00000205808 403313PLPP6

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions