Program

Causal Mechanistic Flows with regulons in program Pr-13

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
ASXL3down-regulatesELF2activatesR-9690.45130814Pr-13
DCHS1down-regulatesELF2activatesR-9690.45130814Pr-13
MYO10down-regulatesELF2activatesR-9690.45130814Pr-13
NEBdown-regulatesELF2activatesR-9690.45130814Pr-13
RNASeq_MAFA_Calldown-regulatesELF2activatesR-9690.45130814Pr-13
SYNE1down-regulatesELF2activatesR-9690.45130814Pr-13
amp1qup-regulatesELF2activatesR-9690.45130814Pr-13
del13up-regulatesELF2activatesR-9690.45130814Pr-13
RNASeq_FGFR3_Callup-regulatesTFEBactivatesR-8840.72799811Pr-13
t(4;14)up-regulatesTFEBactivatesR-8840.72799811Pr-13
ASXL3down-regulatesETV6activatesR-7010.89008814Pr-13
amp1qup-regulatesETV6activatesR-7010.89008814Pr-13
del13up-regulatesETV6activatesR-7010.89008814Pr-13
del1pup-regulatesETV6activatesR-7010.89008814Pr-13
ASXL3down-regulatesGABPB1activatesR-19490.9607799Pr-13
SYNE1down-regulatesGABPB1activatesR-19490.9607799Pr-13
TACC2down-regulatesGABPB1activatesR-19490.9607799Pr-13
del13up-regulatesGABPB1activatesR-19490.9607799Pr-13
ASXL3down-regulatesELK1activatesR-6391.0215516Pr-13
NEBdown-regulatesELK1activatesR-6391.0215516Pr-13
TACC2down-regulatesELK1activatesR-6391.0215516Pr-13
amp1qup-regulatesELK1activatesR-6391.0215516Pr-13
del13up-regulatesELK1activatesR-6391.0215516Pr-13
del1pup-regulatesELK1activatesR-6391.0215516Pr-13
ASXL3down-regulatesMAFKactivatesR-28001.0470120Pr-13
MYO10down-regulatesMAFKactivatesR-28001.0470120Pr-13
RNASeq_MAFA_Calldown-regulatesMAFKactivatesR-28001.0470120Pr-13
SYNE1down-regulatesMAFKactivatesR-28001.0470120Pr-13
TACC2down-regulatesMAFKactivatesR-28001.0470120Pr-13
amp1qup-regulatesMAFKactivatesR-28001.0470120Pr-13
del13up-regulatesMAFKactivatesR-28001.0470120Pr-13
t(11;14)down-regulatesHMGA1activatesR-8231.0578820Pr-13
ROBO1up-regulatesHMGA1activatesR-8231.0578820Pr-13
t(11;14)_cytogeneticdown-regulatesHMGA1activatesR-8231.0578820Pr-13
KIAA1109down-regulatesJUNrepressesR-11781.1027421Pr-13
t(11;14)up-regulatesJUNrepressesR-11781.1027421Pr-13
t(11;14)_cytogeneticup-regulatesJUNrepressesR-11781.1027421Pr-13
t(11;14)down-regulatesNR3C1activatesR-31831.1693118Pr-13
RNASeq_CCND2_Calldown-regulatesNR3C1activatesR-31831.1693118Pr-13
del13up-regulatesNR3C1activatesR-31831.1693118Pr-13
t(11;14)_cytogeneticdown-regulatesNR3C1activatesR-31831.1693118Pr-13
PCLOup-regulatesELK4activatesR-7701.176557Pr-13
t(14;16)up-regulatesELK4activatesR-7701.176557Pr-13
amp1qup-regulatesELK4activatesR-7701.176557Pr-13
del13up-regulatesELK4activatesR-7701.176557Pr-13
del1pup-regulatesELK4activatesR-7701.176557Pr-13
ASXL3down-regulatesBACH1activatesR-4731.20999Pr-13
MYO10down-regulatesBACH1activatesR-4731.20999Pr-13
NEBdown-regulatesBACH1activatesR-4731.20999Pr-13
t(14;16)up-regulatesBACH1activatesR-4731.20999Pr-13
TACC2down-regulatesBACH1activatesR-4731.20999Pr-13
amp1qup-regulatesBACH1activatesR-4731.20999Pr-13
del13up-regulatesBACH1activatesR-4731.20999Pr-13
amp1qup-regulatesELK3activatesR-28481.278166Pr-13
del13up-regulatesELK3activatesR-28481.278166Pr-13
ASXL3up-regulatesRARBrepressesR-11051.285111Pr-13
t(11;14)up-regulatesRARBrepressesR-11051.285111Pr-13
RNASeq_FGFR3_Calldown-regulatesRARBrepressesR-11051.285111Pr-13
t(4;14)down-regulatesRARBrepressesR-11051.285111Pr-13
del13down-regulatesRARBrepressesR-11051.285111Pr-13
ASXL3down-regulatesCEBPGactivatesR-4381.3394216Pr-13
MYO10down-regulatesCEBPGactivatesR-4381.3394216Pr-13
SYNE1down-regulatesCEBPGactivatesR-4381.3394216Pr-13
amp1qup-regulatesCEBPGactivatesR-4381.3394216Pr-13
del13up-regulatesCEBPGactivatesR-4381.3394216Pr-13
NEBdown-regulatesEWSR1activatesR-25461.3425419Pr-13
TACC2down-regulatesEWSR1activatesR-25461.3425419Pr-13
amp1qup-regulatesEWSR1activatesR-25461.3425419Pr-13
del13up-regulatesEWSR1activatesR-25461.3425419Pr-13
MYO10down-regulatesTCF7L1activatesR-31711.377289Pr-13
NEBdown-regulatesTCF7L1activatesR-31711.377289Pr-13
del13up-regulatesTCF7L1activatesR-31711.377289Pr-13
PRUNE2down-regulatesETV3activatesR-25341.640747Pr-13
TACC2down-regulatesETV3activatesR-25341.640747Pr-13
amp1qup-regulatesETV3activatesR-25341.640747Pr-13
del13up-regulatesETV3activatesR-25341.640747Pr-13
t(11;14)up-regulatesENSG00000165066repressesR-30791.9460610Pr-13
t(14;16)down-regulatesENSG00000165066repressesR-30791.9460610Pr-13
amp1qdown-regulatesENSG00000165066repressesR-30791.9460610Pr-13
del13down-regulatesENSG00000165066repressesR-30791.9460610Pr-13
t(11;14)_cytogeneticup-regulatesENSG00000165066repressesR-30791.9460610Pr-13
t(4;14)up-regulatesUSF1activatesR-18581.973437Pr-13
del13up-regulatesUSF1activatesR-18581.973437Pr-13

Regulons in program Pr-13

Regulon Cox Hazard Ratio # genes # causal flows
R-9690.451308148
R-8840.727998112
R-7010.890088144
R-19490.96077994
R-6391.02155166
R-28001.04701207
R-8231.05788203
R-11781.10274213
R-31831.16931184
R-7701.1765575
R-4731.209997
R-28481.2781662
R-11051.2851115
R-4381.33942165
R-25461.34254194
R-31711.3772893
R-25341.6407474
R-30791.94606105
R-18581.9734372

Genes in program Pr-13

EnsEMBL IdEntrez IdPreferred
ENSG00000180694 169200TMEM64
ENSG00000184677 9923ZBTB40
ENSG00000186652 5553PRG2
ENSG00000187554 7100TLR5
ENSG00000188483 389792IER5L
ENSG00000188886
ENSG00000188994 23036ZNF292
ENSG00000196236 63929XPNPEP3
ENSG00000196843 10865ARID5A
ENSG00000196932
ENSG00000197147 23507LRRC8B
ENSG00000197728 6231RPS26
ENSG00000197785 55210ATAD3A
ENSG00000198258 59286UBL5
ENSG00000198265 9931HELZ
ENSG00000198399 50618ITSN2
ENSG00000205307
ENSG00000222009 149478BTBD19
ENSG00000225828 100128071FAM229A

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions