Program

Causal Mechanistic Flows with regulons in program Pr-125

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DNAH10up-regulatesZBTB16activatesR-5890.1855338Pr-125
DNAH5down-regulatesZBTB16activatesR-5890.1855338Pr-125
MAXdown-regulatesZBTB16activatesR-5890.1855338Pr-125
NEBdown-regulatesZBTB16activatesR-5890.1855338Pr-125
t(11;14)up-regulatesZBTB16activatesR-5890.1855338Pr-125
RNASeq_CCND2_Calldown-regulatesZBTB16activatesR-5890.1855338Pr-125
RNASeq_FGFR3_Callup-regulatesZBTB16activatesR-5890.1855338Pr-125
TRAF3down-regulatesZBTB16activatesR-5890.1855338Pr-125
MAXdown-regulatesBBXrepressesR-15380.2458136Pr-125
MXRA5down-regulatesBBXrepressesR-15380.2458136Pr-125
FAT3down-regulatesHSF1activatesR-540.6047318Pr-125
MAXdown-regulatesHSF1activatesR-540.6047318Pr-125
RNASeq_CCND2_Calldown-regulatesHSF1activatesR-540.6047318Pr-125
amp1qup-regulatesHSF1activatesR-540.6047318Pr-125
del13up-regulatesHSF1activatesR-540.6047318Pr-125
AHNAK2down-regulatesEWSR1activatesR-25590.6524927Pr-125
CMYA5down-regulatesEWSR1activatesR-25590.6524927Pr-125
MACF1down-regulatesEWSR1activatesR-25590.6524927Pr-125
t(11;14)up-regulatesEWSR1activatesR-25590.6524927Pr-125
RNASeq_FGFR3_Callup-regulatesEWSR1activatesR-25590.6524927Pr-125
t(4;14)up-regulatesEWSR1activatesR-25590.6524927Pr-125
del13up-regulatesEWSR1activatesR-25590.6524927Pr-125
t(11;14)_cytogeneticup-regulatesEWSR1activatesR-25590.6524927Pr-125
FRAS1down-regulatesDBPrepressesR-29530.9183388Pr-125
IRF4down-regulatesDBPrepressesR-29530.9183388Pr-125
PRKD2down-regulatesDBPrepressesR-29530.9183388Pr-125
t(11;14)down-regulatesDBPrepressesR-29530.9183388Pr-125
t(4;14)up-regulatesDBPrepressesR-29530.9183388Pr-125
DIS3down-regulatesHOXA3repressesR-2230.93626113Pr-125
FAM46Cup-regulatesHOXA3repressesR-2230.93626113Pr-125
IRF4down-regulatesHOXA3repressesR-2230.93626113Pr-125
NEBup-regulatesHOXA3repressesR-2230.93626113Pr-125
PRKD2down-regulatesHOXA3repressesR-2230.93626113Pr-125
t(11;14)down-regulatesHOXA3repressesR-2230.93626113Pr-125
RNASeq_FGFR3_Calldown-regulatesHOXA3repressesR-2230.93626113Pr-125
t(4;14)down-regulatesHOXA3repressesR-2230.93626113Pr-125
t(11;14)_cytogeneticdown-regulatesHOXA3repressesR-2230.93626113Pr-125
amp1qdown-regulatesTRIM28repressesR-15041.068138Pr-125
MYCdown-regulatesNFE2L2activatesR-1914-1.104236Pr-125
t(11;14)_cytogeneticup-regulatesNFE2L2activatesR-1914-1.104236Pr-125
BRAFup-regulatesHSF2activatesR-31621.1464210Pr-125
t(11;14)up-regulatesHSF2activatesR-31621.1464210Pr-125
t(14;16)_cytogeneticdown-regulatesHSF2activatesR-31621.1464210Pr-125
NRASdown-regulatesSMAD4activatesR-23591.511336Pr-125
t(11;14)up-regulatesSMAD4activatesR-23591.511336Pr-125
RNASeq_MAFB_Callup-regulatesSMAD4activatesR-23591.511336Pr-125
t(14;16)up-regulatesSMAD4activatesR-23591.511336Pr-125
t(11;14)_cytogeneticup-regulatesSMAD4activatesR-23591.511336Pr-125
amp1qup-regulatesSPDEFactivatesR-19751.566836Pr-125
del13up-regulatesSPDEFactivatesR-19751.566836Pr-125
FAM46Cup-regulatesESRRArepressesR-27411.727488Pr-125
FRAS1down-regulatesESRRArepressesR-27411.727488Pr-125
IRF4down-regulatesESRRArepressesR-27411.727488Pr-125
NRASup-regulatesESRRArepressesR-27411.727488Pr-125
t(11;14)down-regulatesESRRArepressesR-27411.727488Pr-125
RNASeq_CCND3_Calldown-regulatesESRRArepressesR-27411.727488Pr-125
TRIOdown-regulatesESRRArepressesR-27411.727488Pr-125
t(11;14)_cytogeneticdown-regulatesESRRArepressesR-27411.727488Pr-125
t(11;14)up-regulatesEWSR1activatesR-25472.0779218Pr-125
t(11;14)_cytogeneticup-regulatesEWSR1activatesR-25472.0779218Pr-125
DNAH10up-regulatesRUNX3activatesR-8922.1028415Pr-125
DSTdown-regulatesRUNX3activatesR-8922.1028415Pr-125
FGFR3up-regulatesRUNX3activatesR-8922.1028415Pr-125
IRF4up-regulatesRUNX3activatesR-8922.1028415Pr-125
KIAA1244down-regulatesRUNX3activatesR-8922.1028415Pr-125
KRASup-regulatesRUNX3activatesR-8922.1028415Pr-125
PRKD2up-regulatesRUNX3activatesR-8922.1028415Pr-125
t(11;14)up-regulatesRUNX3activatesR-8922.1028415Pr-125
RNASeq_FGFR3_Callup-regulatesRUNX3activatesR-8922.1028415Pr-125
TRAF3down-regulatesRUNX3activatesR-8922.1028415Pr-125
t(11;14)_cytogeneticup-regulatesRUNX3activatesR-8922.1028415Pr-125
DSTup-regulatesENSG00000186564activatesR-4822.102928Pr-125
RNASeq_MAFB_Callup-regulatesENSG00000186564activatesR-4822.102928Pr-125
t(14;16)up-regulatesENSG00000186564activatesR-4822.102928Pr-125
TRAF3up-regulatesENSG00000186564activatesR-4822.102928Pr-125
NEBdown-regulatesZNF281activatesR-24762.216824Pr-125
t(11;14)up-regulatesZNF281activatesR-24762.216824Pr-125
t(11;14)_cytogeneticup-regulatesZNF281activatesR-24762.216824Pr-125
RNASeq_MAFB_Callup-regulatesTFCP2repressesR-1703-2.820747Pr-125
ROBO1down-regulatesTFCP2repressesR-1703-2.820747Pr-125

Regulons in program Pr-125

Regulon Cox Hazard Ratio # genes # causal flows
R-5890.18553388
R-15380.24581362
R-540.60473185
R-25590.65249278
R-29530.91833885
R-2230.936261139
R-15041.0681381
R-1914-1.1042362
R-31621.14642103
R-23591.5113365
R-19751.5668362
R-27411.7274888
R-25472.07792182
R-8922.102841511
R-4822.1029284
R-24762.2168243
R-1703-2.8207472

Genes in program Pr-125

EnsEMBL IdEntrez IdPreferred
ENSG00000177189 6197RPS6KA3
ENSG00000177628 2629GBA
ENSG00000182952 10473HMGN4
ENSG00000183723 146223CMTM4
ENSG00000187079 7003TEAD1
ENSG00000187244 4059BCAM
ENSG00000189068
ENSG00000196290 60491NIF3L1
ENSG00000196588 57591MKL1
ENSG00000203710 1378CR1
ENSG00000204227 6015RING1
ENSG00000213413 79037PVRIG
ENSG00000239857 51608GET4
ENSG00000241945 102724159LOC102724159
ENSG00000241973 5297PI4KA
ENSG00000250317 389203SMIM20

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions