Program

Causal Mechanistic Flows with regulons in program Pr-118

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
MAXdown-regulatesZNF740activatesR-388-0.05465178Pr-118
RNASeq_FGFR3_Calldown-regulatesZNF740activatesR-388-0.05465178Pr-118
t(4;14)down-regulatesZNF740activatesR-388-0.05465178Pr-118
del13down-regulatesZNF740activatesR-388-0.05465178Pr-118
t(4;14)_cytogeneticdown-regulatesZNF740activatesR-388-0.05465178Pr-118
DIS3up-regulatesJUNrepressesR-11850.143617Pr-118
t(11;14)up-regulatesJUNrepressesR-11850.143617Pr-118
MYCdown-regulatesJUNrepressesR-11850.143617Pr-118
BAI3down-regulatesELF4repressesR-23330.2975823Pr-118
FGFR3up-regulatesELF4repressesR-23330.2975823Pr-118
KIAA1244down-regulatesELF4repressesR-23330.2975823Pr-118
t(11;14)up-regulatesELF4repressesR-23330.2975823Pr-118
RNASeq_FGFR3_Callup-regulatesELF4repressesR-23330.2975823Pr-118
t(14;16)up-regulatesELF4repressesR-23330.2975823Pr-118
TRAF3down-regulatesELF4repressesR-23330.2975823Pr-118
t(11;14)down-regulatesBDP1activatesR-8410.4616916Pr-118
RNASeq_CCND3_Calldown-regulatesBDP1activatesR-8410.4616916Pr-118
t(11;14)_cytogeneticdown-regulatesBDP1activatesR-8410.4616916Pr-118
amp1qup-regulatesELF2repressesR-967-0.7676815Pr-118
del13up-regulatesELF2repressesR-967-0.7676815Pr-118
DIS3down-regulatesHINFPactivatesR-2625-1.110226Pr-118
FAM46Cup-regulatesHINFPactivatesR-2625-1.110226Pr-118
FGFR3down-regulatesHINFPactivatesR-2625-1.110226Pr-118
IRF4down-regulatesHINFPactivatesR-2625-1.110226Pr-118
MAXdown-regulatesHINFPactivatesR-2625-1.110226Pr-118
NRASup-regulatesHINFPactivatesR-2625-1.110226Pr-118
PRKD2down-regulatesHINFPactivatesR-2625-1.110226Pr-118
t(11;14)down-regulatesHINFPactivatesR-2625-1.110226Pr-118
RNASeq_FGFR3_Calldown-regulatesHINFPactivatesR-2625-1.110226Pr-118
RNASeq_MAFA_Calldown-regulatesHINFPactivatesR-2625-1.110226Pr-118
t(14;16)down-regulatesHINFPactivatesR-2625-1.110226Pr-118
MYCup-regulatesHINFPactivatesR-2625-1.110226Pr-118
t(4;14)down-regulatesHINFPactivatesR-2625-1.110226Pr-118
t(4;14)_cytogeneticdown-regulatesHINFPactivatesR-2625-1.110226Pr-118
DIS3up-regulatesNF1repressesR-125-1.329347Pr-118
FAM46Cdown-regulatesNF1repressesR-125-1.329347Pr-118
t(11;14)up-regulatesNF1repressesR-125-1.329347Pr-118
MYCdown-regulatesNF1repressesR-125-1.329347Pr-118
ROBO1down-regulatesNF1repressesR-125-1.329347Pr-118
t(11;14)_cytogeneticup-regulatesNF1repressesR-125-1.329347Pr-118
IRF4down-regulatesNR2C2repressesR-1390-1.413246Pr-118
t(11;14)down-regulatesNR2C2repressesR-1390-1.413246Pr-118
TRAF3down-regulatesNR2C2repressesR-1390-1.413246Pr-118
t(11;14)_cytogeneticdown-regulatesNR2C2repressesR-1390-1.413246Pr-118
FAM46Cdown-regulatesFOSrepressesR-2192-1.630516Pr-118
t(11;14)up-regulatesFOSrepressesR-2192-1.630516Pr-118
RNASeq_FGFR3_Callup-regulatesFOSrepressesR-2192-1.630516Pr-118
MYCdown-regulatesFOSrepressesR-2192-1.630516Pr-118
t(4;14)up-regulatesFOSrepressesR-2192-1.630516Pr-118
ROBO1down-regulatesFOSrepressesR-2192-1.630516Pr-118
t(11;14)_cytogeneticup-regulatesFOSrepressesR-2192-1.630516Pr-118
NRASdown-regulatesUSF1repressesR-1859-1.692166Pr-118
RNASeq_CCND3_Callup-regulatesUSF1repressesR-1859-1.692166Pr-118
MYCdown-regulatesUSF1repressesR-1859-1.692166Pr-118
t(4;14)up-regulatesUSF1repressesR-1859-1.692166Pr-118
del13up-regulatesUSF1repressesR-1859-1.692166Pr-118
DIS3down-regulatesRFX7activatesR-2750-1.731997Pr-118
FAM46Cup-regulatesRFX7activatesR-2750-1.731997Pr-118
HUWE1down-regulatesRFX7activatesR-2750-1.731997Pr-118
IRF4down-regulatesRFX7activatesR-2750-1.731997Pr-118
MAXdown-regulatesRFX7activatesR-2750-1.731997Pr-118
MUC16up-regulatesRFX7activatesR-2750-1.731997Pr-118
NRASup-regulatesRFX7activatesR-2750-1.731997Pr-118
PRKD2down-regulatesRFX7activatesR-2750-1.731997Pr-118
t(11;14)down-regulatesRFX7activatesR-2750-1.731997Pr-118
RNASeq_CCND3_Calldown-regulatesRFX7activatesR-2750-1.731997Pr-118
RNASeq_FGFR3_Calldown-regulatesRFX7activatesR-2750-1.731997Pr-118
RNASeq_MAFA_Calldown-regulatesRFX7activatesR-2750-1.731997Pr-118
t(4;14)down-regulatesRFX7activatesR-2750-1.731997Pr-118
ROBO1up-regulatesRFX7activatesR-2750-1.731997Pr-118
TRIOdown-regulatesRFX7activatesR-2750-1.731997Pr-118
t(11;14)_cytogeneticdown-regulatesRFX7activatesR-2750-1.731997Pr-118
t(4;14)_cytogeneticdown-regulatesRFX7activatesR-2750-1.731997Pr-118
DIS3up-regulatesZFXrepressesR-1922-1.8197210Pr-118
FAM46Cdown-regulatesZFXrepressesR-1922-1.8197210Pr-118
FGFR3up-regulatesZFXrepressesR-1922-1.8197210Pr-118
t(11;14)up-regulatesZFXrepressesR-1922-1.8197210Pr-118
RNASeq_FGFR3_Callup-regulatesZFXrepressesR-1922-1.8197210Pr-118
t(14;16)up-regulatesZFXrepressesR-1922-1.8197210Pr-118
MYCdown-regulatesZFXrepressesR-1922-1.8197210Pr-118
t(4;14)up-regulatesZFXrepressesR-1922-1.8197210Pr-118
amp1qup-regulatesZFXrepressesR-1922-1.8197210Pr-118
del13up-regulatesZFXrepressesR-1922-1.8197210Pr-118
t(4;14)_cytogeneticup-regulatesZFXrepressesR-1922-1.8197210Pr-118
DIS3down-regulatesSRFactivatesR-1788-1.8351411Pr-118
DNAH10down-regulatesSRFactivatesR-1788-1.8351411Pr-118
FAM46Cup-regulatesSRFactivatesR-1788-1.8351411Pr-118
FRAS1down-regulatesSRFactivatesR-1788-1.8351411Pr-118
IRF4down-regulatesSRFactivatesR-1788-1.8351411Pr-118
PRKD2down-regulatesSRFactivatesR-1788-1.8351411Pr-118
t(11;14)down-regulatesSRFactivatesR-1788-1.8351411Pr-118
RNASeq_FGFR3_Calldown-regulatesSRFactivatesR-1788-1.8351411Pr-118
t(14;16)down-regulatesSRFactivatesR-1788-1.8351411Pr-118
t(4;14)down-regulatesSRFactivatesR-1788-1.8351411Pr-118
t(11;14)down-regulatesBDP1activatesR-842-1.839176Pr-118
RNASeq_CCND3_Calldown-regulatesBDP1activatesR-842-1.839176Pr-118
t(11;14)_cytogeneticdown-regulatesBDP1activatesR-842-1.839176Pr-118
DIS3down-regulatesPLAG1activatesR-1521-2.0288312Pr-118
FAM46Cup-regulatesPLAG1activatesR-1521-2.0288312Pr-118
IRF4down-regulatesPLAG1activatesR-1521-2.0288312Pr-118
t(11;14)down-regulatesPLAG1activatesR-1521-2.0288312Pr-118
RNASeq_MAFA_Calldown-regulatesPLAG1activatesR-1521-2.0288312Pr-118
RNASeq_MAFB_Calldown-regulatesPLAG1activatesR-1521-2.0288312Pr-118
t(14;16)down-regulatesPLAG1activatesR-1521-2.0288312Pr-118
t(11;14)_cytogeneticdown-regulatesPLAG1activatesR-1521-2.0288312Pr-118
CMYA5up-regulatesKLF16activatesR-2694-2.1854513Pr-118
DIS3down-regulatesKLF16activatesR-2694-2.1854513Pr-118
FGFR3down-regulatesKLF16activatesR-2694-2.1854513Pr-118
NRASup-regulatesKLF16activatesR-2694-2.1854513Pr-118
t(11;14)down-regulatesKLF16activatesR-2694-2.1854513Pr-118
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2694-2.1854513Pr-118
t(4;14)down-regulatesKLF16activatesR-2694-2.1854513Pr-118
ROBO1up-regulatesKLF16activatesR-2694-2.1854513Pr-118
t(11;14)_cytogeneticdown-regulatesKLF16activatesR-2694-2.1854513Pr-118
t(4;14)_cytogeneticdown-regulatesKLF16activatesR-2694-2.1854513Pr-118
CMYA5down-regulatesNF1repressesR-131-2.280986Pr-118
DIS3up-regulatesNF1repressesR-131-2.280986Pr-118
MYCdown-regulatesNF1repressesR-131-2.280986Pr-118
ROBO1down-regulatesNF1repressesR-131-2.280986Pr-118
AHNAK2down-regulatesGABPB1activatesR-1957-2.29376Pr-118
PTPRDdown-regulatesGABPB1activatesR-1957-2.29376Pr-118
RNASeq_CCND2_Calldown-regulatesGABPB1activatesR-1957-2.29376Pr-118
ATMup-regulatesETV6repressesR-694-2.9286635Pr-118
RNASeq_FGFR3_Callup-regulatesETV6repressesR-694-2.9286635Pr-118
RNASeq_MAFB_Callup-regulatesETV6repressesR-694-2.9286635Pr-118
t(14;16)up-regulatesETV6repressesR-694-2.9286635Pr-118
t(4;14)up-regulatesETV6repressesR-694-2.9286635Pr-118
amp1qup-regulatesETV6repressesR-694-2.9286635Pr-118
del13up-regulatesETV6repressesR-694-2.9286635Pr-118
t(4;14)_cytogeneticup-regulatesETV6repressesR-694-2.9286635Pr-118
BRAFdown-regulatesFLI1activatesR-787-3.0016910Pr-118
DIS3down-regulatesFLI1activatesR-787-3.0016910Pr-118
FAM46Cup-regulatesFLI1activatesR-787-3.0016910Pr-118
IRF4down-regulatesFLI1activatesR-787-3.0016910Pr-118
MAXdown-regulatesFLI1activatesR-787-3.0016910Pr-118
NRASup-regulatesFLI1activatesR-787-3.0016910Pr-118
t(11;14)down-regulatesFLI1activatesR-787-3.0016910Pr-118
RNASeq_FGFR3_Calldown-regulatesFLI1activatesR-787-3.0016910Pr-118
RNASeq_MAFA_Calldown-regulatesFLI1activatesR-787-3.0016910Pr-118
RNASeq_MAFB_Calldown-regulatesFLI1activatesR-787-3.0016910Pr-118
t(14;16)down-regulatesFLI1activatesR-787-3.0016910Pr-118
t(4;14)down-regulatesFLI1activatesR-787-3.0016910Pr-118
TRIOdown-regulatesFLI1activatesR-787-3.0016910Pr-118
del13down-regulatesFLI1activatesR-787-3.0016910Pr-118
t(11;14)_cytogeneticdown-regulatesFLI1activatesR-787-3.0016910Pr-118
t(4;14)_cytogeneticdown-regulatesFLI1activatesR-787-3.0016910Pr-118
DIS3up-regulatesTERF1repressesR-2413-3.065088Pr-118
FGFR3up-regulatesTERF1repressesR-2413-3.065088Pr-118
LTBup-regulatesTERF1repressesR-2413-3.065088Pr-118
PRKD2up-regulatesTERF1repressesR-2413-3.065088Pr-118
RNASeq_FGFR3_Callup-regulatesTERF1repressesR-2413-3.065088Pr-118
t(4;14)up-regulatesTERF1repressesR-2413-3.065088Pr-118
ROBO1down-regulatesTERF1repressesR-2413-3.065088Pr-118
del13up-regulatesTERF1repressesR-2413-3.065088Pr-118
t(4;14)_cytogeneticup-regulatesTERF1repressesR-2413-3.065088Pr-118
DIS3up-regulatesZNF219repressesR-2213-3.1155111Pr-118
FAM46Cdown-regulatesZNF219repressesR-2213-3.1155111Pr-118
FGFR3up-regulatesZNF219repressesR-2213-3.1155111Pr-118
IRF4up-regulatesZNF219repressesR-2213-3.1155111Pr-118
KIAA1244down-regulatesZNF219repressesR-2213-3.1155111Pr-118
MAXup-regulatesZNF219repressesR-2213-3.1155111Pr-118
MUC16down-regulatesZNF219repressesR-2213-3.1155111Pr-118
PRKD2up-regulatesZNF219repressesR-2213-3.1155111Pr-118
t(11;14)up-regulatesZNF219repressesR-2213-3.1155111Pr-118
RNASeq_FGFR3_Callup-regulatesZNF219repressesR-2213-3.1155111Pr-118
t(4;14)up-regulatesZNF219repressesR-2213-3.1155111Pr-118
t(11;14)_cytogeneticup-regulatesZNF219repressesR-2213-3.1155111Pr-118
t(4;14)_cytogeneticup-regulatesZNF219repressesR-2213-3.1155111Pr-118
DIS3down-regulatesKLF16activatesR-2689-3.2942824Pr-118
FGFR3down-regulatesKLF16activatesR-2689-3.2942824Pr-118
NRASup-regulatesKLF16activatesR-2689-3.2942824Pr-118
t(11;14)down-regulatesKLF16activatesR-2689-3.2942824Pr-118
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2689-3.2942824Pr-118
t(4;14)down-regulatesKLF16activatesR-2689-3.2942824Pr-118
ROBO1up-regulatesKLF16activatesR-2689-3.2942824Pr-118
t(11;14)_cytogeneticdown-regulatesKLF16activatesR-2689-3.2942824Pr-118
t(4;14)_cytogeneticdown-regulatesKLF16activatesR-2689-3.2942824Pr-118
FGFR3down-regulatesNR2F6activatesR-1379-4.313219Pr-118
IRF4down-regulatesNR2F6activatesR-1379-4.313219Pr-118
t(11;14)down-regulatesNR2F6activatesR-1379-4.313219Pr-118
RNASeq_FGFR3_Calldown-regulatesNR2F6activatesR-1379-4.313219Pr-118
RNASeq_MAFA_Calldown-regulatesNR2F6activatesR-1379-4.313219Pr-118
t(4;14)down-regulatesNR2F6activatesR-1379-4.313219Pr-118
t(11;14)_cytogeneticdown-regulatesNR2F6activatesR-1379-4.313219Pr-118
t(4;14)_cytogeneticdown-regulatesNR2F6activatesR-1379-4.313219Pr-118
DIS3down-regulatesGRHL1activatesR-3146-4.751896Pr-118
FAM46Cup-regulatesGRHL1activatesR-3146-4.751896Pr-118
FAT3down-regulatesGRHL1activatesR-3146-4.751896Pr-118
IRF4down-regulatesGRHL1activatesR-3146-4.751896Pr-118
NRASup-regulatesGRHL1activatesR-3146-4.751896Pr-118
t(11;14)down-regulatesGRHL1activatesR-3146-4.751896Pr-118
RNASeq_FGFR3_Calldown-regulatesGRHL1activatesR-3146-4.751896Pr-118
RNASeq_MAFB_Calldown-regulatesGRHL1activatesR-3146-4.751896Pr-118
t(14;16)down-regulatesGRHL1activatesR-3146-4.751896Pr-118
t(4;14)down-regulatesGRHL1activatesR-3146-4.751896Pr-118
TRAF3down-regulatesGRHL1activatesR-3146-4.751896Pr-118
amp1qdown-regulatesGRHL1activatesR-3146-4.751896Pr-118
del13down-regulatesGRHL1activatesR-3146-4.751896Pr-118

Regulons in program Pr-118

Regulon Cox Hazard Ratio # genes # causal flows
R-388-0.054651785
R-11850.1436173
R-23330.29758237
R-8410.46169163
R-967-0.76768152
R-2625-1.11022614
R-125-1.3293476
R-1390-1.4132464
R-2192-1.6305167
R-1859-1.6921665
R-2750-1.73199717
R-1922-1.819721011
R-1788-1.835141110
R-842-1.8391763
R-1521-2.02883128
R-2694-2.185451310
R-131-2.2809864
R-1957-2.293763
R-694-2.92866358
R-787-3.001691016
R-2413-3.0650889
R-2213-3.115511113
R-2689-3.29428249
R-1379-4.3132198
R-3146-4.75189613

Genes in program Pr-118

EnsEMBL IdEntrez IdPreferred
ENSG00000175787 169841ZNF169
ENSG00000176714 79635CCDC121
ENSG00000178177 254251LCORL
ENSG00000180891 404093CUEDC1
ENSG00000185198
ENSG00000196323 29068ZBTB44
ENSG00000198160 57708MIER1
ENSG00000198721 10455ECI2
ENSG00000205129 441054C4orf47
ENSG00000213020 81856ZNF611
ENSG00000213462 2086ERV3-1
ENSG00000214511 613227HIGD1C
ENSG00000214736 100188893TOMM6
ENSG00000214756 751071CSKMT
ENSG00000235169 388588SMIM1
ENSG00000248483 134187POU5F2
ENSG00000254986 10072DPP3
ENSG00000255423 55096EBLN2

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions