Program

Causal Mechanistic Flows with regulons in program Pr-1

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
KIAA1109up-regulatesKLF16activatesR-2690-0.054069224Pr-1
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2690-0.054069224Pr-1
RNASeq_FGFR3_Calldown-regulatesENSG00000177374activatesR-23600.058922820Pr-1
RNASeq_MAFA_Callup-regulatesENSG00000177374activatesR-23600.058922820Pr-1
t(14;16)up-regulatesENSG00000177374activatesR-23600.058922820Pr-1
NEBdown-regulatesZBTB16activatesR-5790.064029230Pr-1
DMDup-regulatesELF3activatesR-21360.067616262Pr-1
TACC2down-regulatesELF3activatesR-21360.067616262Pr-1
amp1qup-regulatesELF3activatesR-21360.067616262Pr-1
del13up-regulatesELF3activatesR-21360.067616262Pr-1
del1pup-regulatesELF3activatesR-21360.067616262Pr-1
MAXdown-regulatesCREB1activatesR-2710.097345115Pr-1
t(14;16)up-regulatesCREB1activatesR-2710.097345115Pr-1
amp1qup-regulatesCREB1activatesR-2710.097345115Pr-1
del13up-regulatesCREB1activatesR-2710.097345115Pr-1
t(14;16)up-regulatesKLF7activatesR-2790.12764618Pr-1
amp1qup-regulatesKLF7activatesR-2790.12764618Pr-1
del13up-regulatesKLF7activatesR-2790.12764618Pr-1
PCDH10down-regulatesRUNX3activatesR-891-0.15301926Pr-1
t(11;14)up-regulatesRUNX3activatesR-891-0.15301926Pr-1
t(14;16)up-regulatesRUNX3activatesR-891-0.15301926Pr-1
ASXL3down-regulatesHBP1activatesR-1826-0.15481931Pr-1
MAGI1down-regulatesHBP1activatesR-1826-0.15481931Pr-1
NEBdown-regulatesHBP1activatesR-1826-0.15481931Pr-1
TACC2down-regulatesHBP1activatesR-1826-0.15481931Pr-1
amp1qup-regulatesHBP1activatesR-1826-0.15481931Pr-1
del13up-regulatesHBP1activatesR-1826-0.15481931Pr-1
t(14;16)down-regulatesMGArepressesR-1172-0.1602679Pr-1
ASXL3down-regulatesFOXO1activatesR-13950.1703662Pr-1
MAGI1down-regulatesFOXO1activatesR-13950.1703662Pr-1
NEBdown-regulatesFOXO1activatesR-13950.1703662Pr-1
TACC2down-regulatesFOXO1activatesR-13950.1703662Pr-1
del13up-regulatesFOXO1activatesR-13950.1703662Pr-1
t(14;16)up-regulatesELF4activatesR-23270.17287357Pr-1
del1pup-regulatesELF4activatesR-23270.17287357Pr-1
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-6620.19388939Pr-1
t(14;16)up-regulatesSPIBactivatesR-6620.19388939Pr-1
amp1qup-regulatesSPIBactivatesR-6620.19388939Pr-1
del13up-regulatesSPIBactivatesR-6620.19388939Pr-1
del1pup-regulatesSPIBactivatesR-6620.19388939Pr-1
MAGI1down-regulatesNFIL3activatesR-16850.2245915Pr-1
t(11;14)up-regulatesNFIL3activatesR-16850.2245915Pr-1
TACC2down-regulatesNFIL3activatesR-16850.2245915Pr-1
ASXL3down-regulatesFOXJ3activatesR-28720.32335862Pr-1
MAGI1down-regulatesFOXJ3activatesR-28720.32335862Pr-1
NEBdown-regulatesFOXJ3activatesR-28720.32335862Pr-1
TACC2down-regulatesFOXJ3activatesR-28720.32335862Pr-1
amp1qup-regulatesFOXJ3activatesR-28720.32335862Pr-1
del13up-regulatesFOXJ3activatesR-28720.32335862Pr-1
ASXL3down-regulatesRORAactivatesR-22640.34119626Pr-1
MAGI1down-regulatesRORAactivatesR-22640.34119626Pr-1
amp1qup-regulatesRORAactivatesR-22640.34119626Pr-1
del13up-regulatesRORAactivatesR-22640.34119626Pr-1
del1pup-regulatesRORAactivatesR-22640.34119626Pr-1
PCDH10up-regulatesPARP1repressesR-2635-0.34955415Pr-1
t(11;14)down-regulatesPARP1repressesR-2635-0.34955415Pr-1
RNASeq_FGFR3_Callup-regulatesPARP1repressesR-2635-0.34955415Pr-1
t(4;14)up-regulatesPARP1repressesR-2635-0.34955415Pr-1
MAGI1down-regulatesBCL6activatesR-5330.35510667Pr-1
NEBdown-regulatesBCL6activatesR-5330.35510667Pr-1
ASXL3down-regulatesARID5AactivatesR-596-0.40057625Pr-1
MAGI1down-regulatesARID5AactivatesR-596-0.40057625Pr-1
RNASeq_MAFA_Callup-regulatesARID5AactivatesR-596-0.40057625Pr-1
t(14;16)up-regulatesARID5AactivatesR-596-0.40057625Pr-1
TACC2down-regulatesARID5AactivatesR-596-0.40057625Pr-1
amp1qup-regulatesARID5AactivatesR-596-0.40057625Pr-1
del13up-regulatesARID5AactivatesR-596-0.40057625Pr-1
del1pup-regulatesARID5AactivatesR-596-0.40057625Pr-1
NEBdown-regulatesTFEBactivatesR-8820.40115515Pr-1
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-20450.40471369Pr-1
t(14;16)down-regulatesTCF3repressesR-20450.40471369Pr-1
ASXL3down-regulatesFOXK1activatesR-11900.43346843Pr-1
MAGI1down-regulatesFOXK1activatesR-11900.43346843Pr-1
NEBdown-regulatesFOXK1activatesR-11900.43346843Pr-1
TACC2down-regulatesFOXK1activatesR-11900.43346843Pr-1
amp1qup-regulatesFOXK1activatesR-11900.43346843Pr-1
del13up-regulatesFOXK1activatesR-11900.43346843Pr-1
MAGI1down-regulatesPOU2F1activatesR-690.55991466Pr-1
NEBdown-regulatesPOU2F1activatesR-690.55991466Pr-1
TACC2down-regulatesPOU2F1activatesR-690.55991466Pr-1
amp1qup-regulatesPOU2F1activatesR-690.55991466Pr-1
del13up-regulatesPOU2F1activatesR-690.55991466Pr-1
DMDup-regulatesZNF281activatesR-24740.57176842Pr-1
NEBdown-regulatesZNF281activatesR-24740.57176842Pr-1
TACC2down-regulatesZNF281activatesR-24740.57176842Pr-1
amp1qup-regulatesZNF281activatesR-24740.57176842Pr-1
del13up-regulatesZNF281activatesR-24740.57176842Pr-1
NEBup-regulatesPAX6repressesR-15430.59024729Pr-1
t(14;16)down-regulatesPAX6repressesR-15430.59024729Pr-1
amp1qdown-regulatesPAX6repressesR-15430.59024729Pr-1
del13down-regulatesPAX6repressesR-15430.59024729Pr-1
MAGI1down-regulatesSPI1activatesR-26000.59854366Pr-1
NEBdown-regulatesSPI1activatesR-26000.59854366Pr-1
ASXL3down-regulatesFOXJ2activatesR-14190.6060764Pr-1
MAGI1down-regulatesFOXJ2activatesR-14190.6060764Pr-1
t(14;16)up-regulatesFOXJ2activatesR-14190.6060764Pr-1
TACC2down-regulatesFOXJ2activatesR-14190.6060764Pr-1
amp1qup-regulatesFOXJ2activatesR-14190.6060764Pr-1
del13up-regulatesFOXJ2activatesR-14190.6060764Pr-1
ASXL3down-regulatesCEBPGactivatesR-4340.62052636Pr-1
NEBdown-regulatesCEBPGactivatesR-4340.62052636Pr-1
TACC2down-regulatesCEBPGactivatesR-4340.62052636Pr-1
amp1qup-regulatesCEBPGactivatesR-4340.62052636Pr-1
del13up-regulatesCEBPGactivatesR-4340.62052636Pr-1
DCHS1up-regulatesATF1repressesR-5610.64376517Pr-1
t(14;16)down-regulatesTP53repressesR-359-0.69083630Pr-1
amp1qdown-regulatesTP53repressesR-359-0.69083630Pr-1
del13down-regulatesTP53repressesR-359-0.69083630Pr-1
t(14;16)up-regulatesPRDM4activatesR-30740.74287611Pr-1
amp1qup-regulatesPRDM4activatesR-30740.74287611Pr-1
del13up-regulatesPRDM4activatesR-30740.74287611Pr-1
ASXL3up-regulatesRARBrepressesR-11030.81881122Pr-1
del13down-regulatesRARBrepressesR-11030.81881122Pr-1
NEBdown-regulatesTCF7L1activatesR-31690.84651715Pr-1
del13up-regulatesTCF7L1activatesR-31690.84651715Pr-1
DMDup-regulatesEWSR1activatesR-25420.86168864Pr-1
NEBdown-regulatesEWSR1activatesR-25420.86168864Pr-1
PCDH10down-regulatesEWSR1activatesR-25420.86168864Pr-1
t(11;14)up-regulatesEWSR1activatesR-25420.86168864Pr-1
t(14;16)up-regulatesEWSR1activatesR-25420.86168864Pr-1
TACC2down-regulatesEWSR1activatesR-25420.86168864Pr-1
amp1qup-regulatesEWSR1activatesR-25420.86168864Pr-1
del13up-regulatesEWSR1activatesR-25420.86168864Pr-1
BAI3down-regulatesCREB5activatesR-7740.87183215Pr-1
amp1qup-regulatesCREB5activatesR-7740.87183215Pr-1
del13up-regulatesCREB5activatesR-7740.87183215Pr-1
ASXL3down-regulatesCDC5LactivatesR-16300.8732314Pr-1
MAGI1down-regulatesCDC5LactivatesR-16300.8732314Pr-1
NEBdown-regulatesCDC5LactivatesR-16300.8732314Pr-1
RNASeq_MAFA_Callup-regulatesCDC5LactivatesR-16300.8732314Pr-1
t(14;16)up-regulatesCDC5LactivatesR-16300.8732314Pr-1
TACC2down-regulatesCDC5LactivatesR-16300.8732314Pr-1
amp1qup-regulatesCDC5LactivatesR-16300.8732314Pr-1
del13up-regulatesCDC5LactivatesR-16300.8732314Pr-1
del1pup-regulatesCDC5LactivatesR-16300.8732314Pr-1
RNASeq_MAFA_Callup-regulatesNR3C1activatesR-31760.91899237Pr-1
t(14;16)up-regulatesNR3C1activatesR-31760.91899237Pr-1
del13up-regulatesNR3C1activatesR-31760.91899237Pr-1
MAGI1down-regulatesENSG00000054598activatesR-9980.97828154Pr-1
NEBdown-regulatesENSG00000054598activatesR-9980.97828154Pr-1
MAGI1down-regulatesMEF2AactivatesR-18641.0874564Pr-1
TACC2down-regulatesMEF2AactivatesR-18641.0874564Pr-1
amp1qup-regulatesMEF2AactivatesR-18641.0874564Pr-1
del13up-regulatesMEF2AactivatesR-18641.0874564Pr-1
MAGI1down-regulatesSPDEFactivatesR-19591.1590327Pr-1
amp1qup-regulatesSPDEFactivatesR-19591.1590327Pr-1
del13up-regulatesSPDEFactivatesR-19591.1590327Pr-1
NEBdown-regulatesPRDM1activatesR-20741.2254932Pr-1