Causal Mechanistic Flows with regulons in program Pr-43
| Mutation | Role | Regulator | Role | Regulon | Hazard Ratio | # regulon genes | Transcriptional Program |
|---|---|---|---|---|---|---|---|
| amp1q | up-regulates | ARID5A | represses | R-608 | -3.9734 | 7 | Pr-43 |
| del13 | up-regulates | ARID5A | represses | R-608 | -3.9734 | 7 | Pr-43 |
| DIS3 | down-regulates | ESRRA | activates | R-2745 | -3.32726 | 7 | Pr-43 |
| FAM46C | up-regulates | ESRRA | activates | R-2745 | -3.32726 | 7 | Pr-43 |
| FGFR3 | down-regulates | ESRRA | activates | R-2745 | -3.32726 | 7 | Pr-43 |
| FRAS1 | down-regulates | ESRRA | activates | R-2745 | -3.32726 | 7 | Pr-43 |
| IRF4 | down-regulates | ESRRA | activates | R-2745 | -3.32726 | 7 | Pr-43 |
| MUC16 | up-regulates | ESRRA | activates | R-2745 | -3.32726 | 7 | Pr-43 |
| NEB | down-regulates | ARID5A | represses | R-608 | -3.9734 | 7 | Pr-43 |
| PRKD2 | down-regulates | ESRRA | activates | R-2745 | -3.32726 | 7 | Pr-43 |
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