Program

Causal Mechanistic Flows with regulons in program Pr-1

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
KIAA1109up-regulatesKLF16activatesR-2690-0.054069224Pr-1
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2690-0.054069224Pr-1
RNASeq_FGFR3_Calldown-regulatesENSG00000177374activatesR-23600.058922820Pr-1
RNASeq_MAFA_Callup-regulatesENSG00000177374activatesR-23600.058922820Pr-1
t(14;16)up-regulatesENSG00000177374activatesR-23600.058922820Pr-1
NEBdown-regulatesZBTB16activatesR-5790.064029230Pr-1
DMDup-regulatesELF3activatesR-21360.067616262Pr-1
TACC2down-regulatesELF3activatesR-21360.067616262Pr-1
amp1qup-regulatesELF3activatesR-21360.067616262Pr-1
del13up-regulatesELF3activatesR-21360.067616262Pr-1
del1pup-regulatesELF3activatesR-21360.067616262Pr-1
MAXdown-regulatesCREB1activatesR-2710.097345115Pr-1
t(14;16)up-regulatesCREB1activatesR-2710.097345115Pr-1
amp1qup-regulatesCREB1activatesR-2710.097345115Pr-1
del13up-regulatesCREB1activatesR-2710.097345115Pr-1
t(14;16)up-regulatesKLF7activatesR-2790.12764618Pr-1
amp1qup-regulatesKLF7activatesR-2790.12764618Pr-1
del13up-regulatesKLF7activatesR-2790.12764618Pr-1
PCDH10down-regulatesRUNX3activatesR-891-0.15301926Pr-1
t(11;14)up-regulatesRUNX3activatesR-891-0.15301926Pr-1
t(14;16)up-regulatesRUNX3activatesR-891-0.15301926Pr-1
ASXL3down-regulatesHBP1activatesR-1826-0.15481931Pr-1
MAGI1down-regulatesHBP1activatesR-1826-0.15481931Pr-1
NEBdown-regulatesHBP1activatesR-1826-0.15481931Pr-1
TACC2down-regulatesHBP1activatesR-1826-0.15481931Pr-1
amp1qup-regulatesHBP1activatesR-1826-0.15481931Pr-1
del13up-regulatesHBP1activatesR-1826-0.15481931Pr-1
t(14;16)down-regulatesMGArepressesR-1172-0.1602679Pr-1
ASXL3down-regulatesFOXO1activatesR-13950.1703662Pr-1
MAGI1down-regulatesFOXO1activatesR-13950.1703662Pr-1
NEBdown-regulatesFOXO1activatesR-13950.1703662Pr-1
TACC2down-regulatesFOXO1activatesR-13950.1703662Pr-1
del13up-regulatesFOXO1activatesR-13950.1703662Pr-1
t(14;16)up-regulatesELF4activatesR-23270.17287357Pr-1
del1pup-regulatesELF4activatesR-23270.17287357Pr-1
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-6620.19388939Pr-1
t(14;16)up-regulatesSPIBactivatesR-6620.19388939Pr-1
amp1qup-regulatesSPIBactivatesR-6620.19388939Pr-1
del13up-regulatesSPIBactivatesR-6620.19388939Pr-1
del1pup-regulatesSPIBactivatesR-6620.19388939Pr-1
MAGI1down-regulatesNFIL3activatesR-16850.2245915Pr-1
t(11;14)up-regulatesNFIL3activatesR-16850.2245915Pr-1
TACC2down-regulatesNFIL3activatesR-16850.2245915Pr-1
ASXL3down-regulatesFOXJ3activatesR-28720.32335862Pr-1
MAGI1down-regulatesFOXJ3activatesR-28720.32335862Pr-1
NEBdown-regulatesFOXJ3activatesR-28720.32335862Pr-1
TACC2down-regulatesFOXJ3activatesR-28720.32335862Pr-1
amp1qup-regulatesFOXJ3activatesR-28720.32335862Pr-1
del13up-regulatesFOXJ3activatesR-28720.32335862Pr-1
ASXL3down-regulatesRORAactivatesR-22640.34119626Pr-1
MAGI1down-regulatesRORAactivatesR-22640.34119626Pr-1
amp1qup-regulatesRORAactivatesR-22640.34119626Pr-1
del13up-regulatesRORAactivatesR-22640.34119626Pr-1
del1pup-regulatesRORAactivatesR-22640.34119626Pr-1
PCDH10up-regulatesPARP1repressesR-2635-0.34955415Pr-1
t(11;14)down-regulatesPARP1repressesR-2635-0.34955415Pr-1
RNASeq_FGFR3_Callup-regulatesPARP1repressesR-2635-0.34955415Pr-1
t(4;14)up-regulatesPARP1repressesR-2635-0.34955415Pr-1
MAGI1down-regulatesBCL6activatesR-5330.35510667Pr-1
NEBdown-regulatesBCL6activatesR-5330.35510667Pr-1
ASXL3down-regulatesARID5AactivatesR-596-0.40057625Pr-1
MAGI1down-regulatesARID5AactivatesR-596-0.40057625Pr-1
RNASeq_MAFA_Callup-regulatesARID5AactivatesR-596-0.40057625Pr-1
t(14;16)up-regulatesARID5AactivatesR-596-0.40057625Pr-1
TACC2down-regulatesARID5AactivatesR-596-0.40057625Pr-1
amp1qup-regulatesARID5AactivatesR-596-0.40057625Pr-1
del13up-regulatesARID5AactivatesR-596-0.40057625Pr-1
del1pup-regulatesARID5AactivatesR-596-0.40057625Pr-1
NEBdown-regulatesTFEBactivatesR-8820.40115515Pr-1
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-20450.40471369Pr-1
t(14;16)down-regulatesTCF3repressesR-20450.40471369Pr-1
ASXL3down-regulatesFOXK1activatesR-11900.43346843Pr-1
MAGI1down-regulatesFOXK1activatesR-11900.43346843Pr-1
NEBdown-regulatesFOXK1activatesR-11900.43346843Pr-1
TACC2down-regulatesFOXK1activatesR-11900.43346843Pr-1
amp1qup-regulatesFOXK1activatesR-11900.43346843Pr-1
del13up-regulatesFOXK1activatesR-11900.43346843Pr-1
MAGI1down-regulatesPOU2F1activatesR-690.55991466Pr-1
NEBdown-regulatesPOU2F1activatesR-690.55991466Pr-1
TACC2down-regulatesPOU2F1activatesR-690.55991466Pr-1
amp1qup-regulatesPOU2F1activatesR-690.55991466Pr-1
del13up-regulatesPOU2F1activatesR-690.55991466Pr-1
DMDup-regulatesZNF281activatesR-24740.57176842Pr-1
NEBdown-regulatesZNF281activatesR-24740.57176842Pr-1
TACC2down-regulatesZNF281activatesR-24740.57176842Pr-1
amp1qup-regulatesZNF281activatesR-24740.57176842Pr-1
del13up-regulatesZNF281activatesR-24740.57176842Pr-1
NEBup-regulatesPAX6repressesR-15430.59024729Pr-1
t(14;16)down-regulatesPAX6repressesR-15430.59024729Pr-1
amp1qdown-regulatesPAX6repressesR-15430.59024729Pr-1
del13down-regulatesPAX6repressesR-15430.59024729Pr-1
MAGI1down-regulatesSPI1activatesR-26000.59854366Pr-1
NEBdown-regulatesSPI1activatesR-26000.59854366Pr-1
ASXL3down-regulatesFOXJ2activatesR-14190.6060764Pr-1
MAGI1down-regulatesFOXJ2activatesR-14190.6060764Pr-1
t(14;16)up-regulatesFOXJ2activatesR-14190.6060764Pr-1
TACC2down-regulatesFOXJ2activatesR-14190.6060764Pr-1
amp1qup-regulatesFOXJ2activatesR-14190.6060764Pr-1
del13up-regulatesFOXJ2activatesR-14190.6060764Pr-1
ASXL3down-regulatesCEBPGactivatesR-4340.62052636Pr-1
NEBdown-regulatesCEBPGactivatesR-4340.62052636Pr-1
TACC2down-regulatesCEBPGactivatesR-4340.62052636Pr-1
amp1qup-regulatesCEBPGactivatesR-4340.62052636Pr-1
del13up-regulatesCEBPGactivatesR-4340.62052636Pr-1
DCHS1up-regulatesATF1repressesR-5610.64376517Pr-1
t(14;16)down-regulatesTP53repressesR-359-0.69083630Pr-1
amp1qdown-regulatesTP53repressesR-359-0.69083630Pr-1
del13down-regulatesTP53repressesR-359-0.69083630Pr-1
t(14;16)up-regulatesPRDM4activatesR-30740.74287611Pr-1
amp1qup-regulatesPRDM4activatesR-30740.74287611Pr-1
del13up-regulatesPRDM4activatesR-30740.74287611Pr-1
ASXL3up-regulatesRARBrepressesR-11030.81881122Pr-1
del13down-regulatesRARBrepressesR-11030.81881122Pr-1
NEBdown-regulatesTCF7L1activatesR-31690.84651715Pr-1
del13up-regulatesTCF7L1activatesR-31690.84651715Pr-1
DMDup-regulatesEWSR1activatesR-25420.86168864Pr-1
NEBdown-regulatesEWSR1activatesR-25420.86168864Pr-1
PCDH10down-regulatesEWSR1activatesR-25420.86168864Pr-1
t(11;14)up-regulatesEWSR1activatesR-25420.86168864Pr-1
t(14;16)up-regulatesEWSR1activatesR-25420.86168864Pr-1
TACC2down-regulatesEWSR1activatesR-25420.86168864Pr-1
amp1qup-regulatesEWSR1activatesR-25420.86168864Pr-1
del13up-regulatesEWSR1activatesR-25420.86168864Pr-1
BAI3down-regulatesCREB5activatesR-7740.87183215Pr-1
amp1qup-regulatesCREB5activatesR-7740.87183215Pr-1
del13up-regulatesCREB5activatesR-7740.87183215Pr-1
ASXL3down-regulatesCDC5LactivatesR-16300.8732314Pr-1
MAGI1down-regulatesCDC5LactivatesR-16300.8732314Pr-1
NEBdown-regulatesCDC5LactivatesR-16300.8732314Pr-1
RNASeq_MAFA_Callup-regulatesCDC5LactivatesR-16300.8732314Pr-1
t(14;16)up-regulatesCDC5LactivatesR-16300.8732314Pr-1
TACC2down-regulatesCDC5LactivatesR-16300.8732314Pr-1
amp1qup-regulatesCDC5LactivatesR-16300.8732314Pr-1
del13up-regulatesCDC5LactivatesR-16300.8732314Pr-1
del1pup-regulatesCDC5LactivatesR-16300.8732314Pr-1
RNASeq_MAFA_Callup-regulatesNR3C1activatesR-31760.91899237Pr-1
t(14;16)up-regulatesNR3C1activatesR-31760.91899237Pr-1
del13up-regulatesNR3C1activatesR-31760.91899237Pr-1
MAGI1down-regulatesENSG00000054598activatesR-9980.97828154Pr-1
NEBdown-regulatesENSG00000054598activatesR-9980.97828154Pr-1
MAGI1down-regulatesMEF2AactivatesR-18641.0874564Pr-1
TACC2down-regulatesMEF2AactivatesR-18641.0874564Pr-1
amp1qup-regulatesMEF2AactivatesR-18641.0874564Pr-1
del13up-regulatesMEF2AactivatesR-18641.0874564Pr-1
MAGI1down-regulatesSPDEFactivatesR-19591.1590327Pr-1
amp1qup-regulatesSPDEFactivatesR-19591.1590327Pr-1
del13up-regulatesSPDEFactivatesR-19591.1590327Pr-1
NEBdown-regulatesPRDM1activatesR-20741.2254932Pr-1
t(14;16)up-regulatesPRDM1activatesR-20741.2254932Pr-1
amp1qup-regulatesPRDM1activatesR-20741.2254932Pr-1
del13up-regulatesPRDM1activatesR-20741.2254932Pr-1
del1pup-regulatesPRDM1activatesR-20741.2254932Pr-1
AHNAK2down-regulatesSRFactivatesR-1789-1.225689Pr-1
RNASeq_FGFR3_Calldown-regulatesSRFactivatesR-1789-1.225689Pr-1
t(4;14)down-regulatesSRFactivatesR-1789-1.225689Pr-1
ASXL3down-regulatesSTAT3activatesR-3021.2828528Pr-1
t(14;16)up-regulatesSTAT3activatesR-3021.2828528Pr-1
TACC2down-regulatesSTAT3activatesR-3021.2828528Pr-1
amp1qup-regulatesSTAT3activatesR-3021.2828528Pr-1
del13up-regulatesSTAT3activatesR-3021.2828528Pr-1
del1pup-regulatesENSG00000179348activatesR-10621.347598Pr-1
RNASeq_MAFB_Callup-regulatesENSG00000186564activatesR-4831.556387Pr-1
t(14;16)up-regulatesENSG00000186564activatesR-4831.556387Pr-1
BRAFup-regulatesZEB1activatesR-22491.6983610Pr-1
RNASeq_MAFA_Callup-regulatesZEB1activatesR-22491.6983610Pr-1
t(14;16)up-regulatesZEB1activatesR-22491.6983610Pr-1
TACC2down-regulatesZEB1activatesR-22491.6983610Pr-1
amp1qup-regulatesZEB1activatesR-22491.6983610Pr-1
del13up-regulatesZEB1activatesR-22491.6983610Pr-1
amp1qup-regulatesHBP1activatesR-18411.703439Pr-1
del13up-regulatesHBP1activatesR-18411.703439Pr-1
DIS3up-regulatesZFXactivatesR-19251.750388Pr-1
t(11;14)up-regulatesZFXactivatesR-19251.750388Pr-1
RNASeq_FGFR3_Callup-regulatesZFXactivatesR-19251.750388Pr-1
t(14;16)up-regulatesZFXactivatesR-19251.750388Pr-1
t(4;14)up-regulatesZFXactivatesR-19251.750388Pr-1
amp1qup-regulatesZFXactivatesR-19251.750388Pr-1
del13up-regulatesZFXactivatesR-19251.750388Pr-1
t(4;14)_cytogeneticup-regulatesZFXactivatesR-19251.750388Pr-1
PCDH10down-regulatesCEBPGactivatesR-4472.017489Pr-1
amp1qup-regulatesCEBPGactivatesR-4472.017489Pr-1
del13up-regulatesCEBPGactivatesR-4472.017489Pr-1
TACC2down-regulatesMAFKactivatesR-28082.0292410Pr-1
amp1qup-regulatesMAFKactivatesR-28082.0292410Pr-1
del13up-regulatesMAFKactivatesR-28082.0292410Pr-1
DIS3up-regulatesMEF2DactivatesR-8742.643249Pr-1
RNASeq_FGFR3_Callup-regulatesMEF2DactivatesR-8742.643249Pr-1
RNASeq_MAFB_Callup-regulatesMEF2DactivatesR-8742.643249Pr-1
t(14;16)up-regulatesMEF2DactivatesR-8742.643249Pr-1
t(4;14)up-regulatesMEF2DactivatesR-8742.643249Pr-1
amp1qup-regulatesMEF2DactivatesR-8742.643249Pr-1
del13up-regulatesMEF2DactivatesR-8742.643249Pr-1
t(14;16)_cytogeneticup-regulatesMEF2DactivatesR-8742.643249Pr-1
t(4;14)_cytogeneticup-regulatesMEF2DactivatesR-8742.643249Pr-1
ATMup-regulatesPEBP1activatesR-17552.807117Pr-1
DIS3up-regulatesPEBP1activatesR-17552.807117Pr-1
IRF4up-regulatesPEBP1activatesR-17552.807117Pr-1
LTBup-regulatesPEBP1activatesR-17552.807117Pr-1
NRASdown-regulatesPEBP1activatesR-17552.807117Pr-1
PRDM1up-regulatesPEBP1activatesR-17552.807117Pr-1
t(11;14)up-regulatesPEBP1activatesR-17552.807117Pr-1
RNASeq_FGFR3_Callup-regulatesPEBP1activatesR-17552.807117Pr-1
RNASeq_MAFA_Callup-regulatesPEBP1activatesR-17552.807117Pr-1
RNASeq_MAFB_Callup-regulatesPEBP1activatesR-17552.807117Pr-1
t(14;16)up-regulatesPEBP1activatesR-17552.807117Pr-1
t(4;14)up-regulatesPEBP1activatesR-17552.807117Pr-1
TRIOup-regulatesPEBP1activatesR-17552.807117Pr-1
amp1qup-regulatesPEBP1activatesR-17552.807117Pr-1
del13up-regulatesPEBP1activatesR-17552.807117Pr-1
t(4;14)_cytogeneticup-regulatesPEBP1activatesR-17552.807117Pr-1
RNASeq_FGFR3_Calldown-regulatesZNF740repressesR-3932.829286Pr-1
RNASeq_MAFA_Calldown-regulatesZNF740repressesR-3932.829286Pr-1
t(14;16)down-regulatesZNF740repressesR-3932.829286Pr-1
t(4;14)down-regulatesZNF740repressesR-3932.829286Pr-1
SP140down-regulatesZNF740repressesR-3932.829286Pr-1
amp1qdown-regulatesZNF740repressesR-3932.829286Pr-1
del13down-regulatesZNF740repressesR-3932.829286Pr-1
t(4;14)_cytogeneticdown-regulatesZNF740repressesR-3932.829286Pr-1
amp1qup-regulatesELF2activatesR-9882.94367Pr-1
del13up-regulatesELF2activatesR-9882.94367Pr-1
RNASeq_FGFR3_Calldown-regulatesRARBrepressesR-11093.056267Pr-1
t(4;14)down-regulatesRARBrepressesR-11093.056267Pr-1
del13down-regulatesRARBrepressesR-11093.056267Pr-1
t(4;14)_cytogeneticdown-regulatesRARBrepressesR-11093.056267Pr-1

Regulons in program Pr-1

Regulon Cox Hazard Ratio # genes # causal flows
R-2690-0.0540692242
R-23600.0589228203
R-5790.0640292301
R-21360.0676162625
R-2710.0973451154
R-2790.127646183
R-891-0.153019263
R-1826-0.154819316
R-1172-0.16026791
R-13950.17036625
R-23270.172873572
R-6620.193889395
R-16850.22459153
R-28720.323358626
R-22640.341196265
R-2635-0.349554154
R-5330.355106672
R-596-0.400576258
R-8820.401155151
R-20450.404713692
R-11900.433468436
R-690.559914665
R-24740.571768425
R-15430.590247294
R-26000.598543662
R-14190.60607646
R-4340.620526365
R-5610.643765171
R-359-0.690836303
R-30740.742876113
R-11030.818811222
R-31690.846517152
R-25420.861688648
R-7740.871832153
R-16300.87323149
R-31760.918992373
R-9980.978281542
R-18641.08745644
R-19591.15903273
R-20741.22549325
R-1789-1.2256893
R-3021.28285285
R-10621.3475981
R-4831.5563872
R-22491.69836106
R-18411.7034392
R-19251.7503888
R-4472.0174893
R-28082.02924103
R-8742.6432499
R-17552.80711716
R-3932.8292868
R-9882.943672
R-11093.0562674

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions