Program

Causal Mechanistic Flows with regulons in program Pr-34

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
t(11;14)up-regulatesTRAF4activatesR-3038-0.14394915Pr-34
t(11;14)up-regulatesMAFGactivatesR-14870.45660411Pr-34
t(4;14)up-regulatesMAFGactivatesR-14870.45660411Pr-34
amp1qup-regulatesMAFGactivatesR-14870.45660411Pr-34
del13up-regulatesMAFGactivatesR-14870.45660411Pr-34
ABCA13down-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
AHNAK2down-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
CMYA5down-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
DNAH5down-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
NEBdown-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
t(11;14)up-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
RNASeq_FGFR3_Callup-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
RNASeq_MAFA_Calldown-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
t(4;14)up-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
SYNE1down-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
amp1qup-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
del13up-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
t(11;14)_cytogeneticup-regulatesFOXJ3activatesR-2881-0.59023228Pr-34
ABCA13down-regulatesFOXJ2activatesR-1430-0.91689428Pr-34
AHNAK2down-regulatesFOXJ2activatesR-1430-0.91689428Pr-34
t(11;14)up-regulatesFOXJ2activatesR-1430-0.91689428Pr-34
t(4;14)up-regulatesFOXJ2activatesR-1430-0.91689428Pr-34
amp1qup-regulatesFOXJ2activatesR-1430-0.91689428Pr-34
del13up-regulatesFOXJ2activatesR-1430-0.91689428Pr-34
DNAH5down-regulatesHBP1activatesR-1835-0.94452415Pr-34
KALRNdown-regulatesHBP1activatesR-1835-0.94452415Pr-34
MACF1down-regulatesHBP1activatesR-1835-0.94452415Pr-34
t(11;14)up-regulatesHBP1activatesR-1835-0.94452415Pr-34
del13up-regulatesHBP1activatesR-1835-0.94452415Pr-34
AHNAK2down-regulatesZEB1activatesR-2239-1.4087718Pr-34
del13up-regulatesZEB1activatesR-2239-1.4087718Pr-34

Regulons in program Pr-34

Regulon Cox Hazard Ratio # genes # causal flows
R-3038-0.143949151
R-14870.456604114
R-2881-0.5902322813
R-1430-0.916894286
R-1835-0.944524155
R-2239-1.40877182

Genes in program Pr-34

EnsEMBL IdEntrez IdPreferred
ENSG00000176715 197322ACSF3
ENSG00000180817 5464PPA1
ENSG00000182809 1397CRIP2
ENSG00000187049 51259TMEM216
ENSG00000187391 9863MAGI2
ENSG00000198718 23116TOGARAM1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions