Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ARID5A - AT-rich interaction domain 5A

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
10865 ENSG00000196843 ARID5A Q03989

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ARID5A

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
NEBARID5ArepressesR-610-0.170127Pr-135
TACC2ARID5ArepressesR-610-0.170127Pr-135
del13ARID5ArepressesR-610-0.170127Pr-135
RNASeq_MAFA_CallARID5AactivatesR-597-0.298346Pr-85
t(14;16)ARID5AactivatesR-597-0.298346Pr-85
amp1qARID5AactivatesR-597-0.298346Pr-85
del13ARID5AactivatesR-597-0.298346Pr-85
del1pARID5AactivatesR-597-0.298346Pr-85
ASXL3ARID5AactivatesR-596-0.400576Pr-1
MAGI1ARID5AactivatesR-596-0.400576Pr-1
RNASeq_MAFA_CallARID5AactivatesR-596-0.400576Pr-1
t(14;16)ARID5AactivatesR-596-0.400576Pr-1
TACC2ARID5AactivatesR-596-0.400576Pr-1
amp1qARID5AactivatesR-596-0.400576Pr-1
del13ARID5AactivatesR-596-0.400576Pr-1
del1pARID5AactivatesR-596-0.400576Pr-1
KIAA1109ARID5ArepressesR-6010.900146Pr-59
amp1qARID5ArepressesR-6010.900146Pr-59
ASXL3ARID5AactivatesR-595-1.02768Pr-0
MAGI1ARID5AactivatesR-595-1.02768Pr-0
NEBARID5AactivatesR-595-1.02768Pr-0
TACC2ARID5AactivatesR-595-1.02768Pr-0
amp1qARID5AactivatesR-595-1.02768Pr-0
del13ARID5AactivatesR-595-1.02768Pr-0
RNASeq_MAFA_CallARID5AactivatesR-6041.06015Pr-18
t(14;16)ARID5AactivatesR-6041.06015Pr-18
amp1qARID5AactivatesR-6041.06015Pr-18
del13ARID5AactivatesR-6041.06015Pr-18
NEBARID5AactivatesR-599-1.1493Pr-2
TACC2ARID5AactivatesR-599-1.1493Pr-2
del13ARID5AactivatesR-599-1.1493Pr-2
DMDARID5AactivatesR-607-1.1537Pr-10
RNASeq_MAFA_CallARID5AactivatesR-600-1.16018Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

t(14;16)ARID5AactivatesR-600-1.16018Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

amp1qARID5AactivatesR-600-1.16018Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

del13ARID5AactivatesR-600-1.16018Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

del1pARID5AactivatesR-600-1.16018Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

TACC2ARID5AactivatesR-602-2.062Pr-28
del13ARID5AactivatesR-602-2.062Pr-28
RNASeq_MAFA_CallARID5AactivatesR-598-2.47726Pr-17
t(14;16)ARID5AactivatesR-598-2.47726Pr-17
amp1qARID5AactivatesR-598-2.47726Pr-17
del13ARID5AactivatesR-598-2.47726Pr-17
del1pARID5AactivatesR-598-2.47726Pr-17
t(14;16)ARID5AactivatesR-605-2.71353Pr-110
amp1qARID5AactivatesR-605-2.71353Pr-110
del13ARID5AactivatesR-605-2.71353Pr-110
MAGI1ARID5AactivatesR-6092.81438Pr-108
amp1qARID5AactivatesR-6092.81438Pr-108
del13ARID5AactivatesR-6092.81438Pr-108
t(14;16)ARID5AactivatesR-603-3.17009Pr-11
TACC2ARID5AactivatesR-603-3.17009Pr-11
amp1qARID5AactivatesR-603-3.17009Pr-11
del13ARID5AactivatesR-603-3.17009Pr-11
NEBARID5ArepressesR-608-3.9734Pr-43

Genes (1)

C14orf132

Regulons (3)

R-3072, R-2745, R-608

amp1qARID5ArepressesR-608-3.9734Pr-43

Genes (1)

C14orf132

Regulons (3)

R-3072, R-2745, R-608

del13ARID5ArepressesR-608-3.9734Pr-43

Genes (1)

C14orf132

Regulons (3)

R-3072, R-2745, R-608

DMDARID5ArepressesR-606-4.76793Pr-99
KIAA1109ARID5ArepressesR-606-4.76793Pr-99
NEBARID5ArepressesR-606-4.76793Pr-99
t(14;16)ARID5ArepressesR-606-4.76793Pr-99
amp1qARID5ArepressesR-606-4.76793Pr-99
del13ARID5ArepressesR-606-4.76793Pr-99
del1pARID5ArepressesR-606-4.76793Pr-99

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.