Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ELK1 - ETS transcription factor ELK1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
2002 ENSG00000126767 ELK1 P19419

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ELK1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
t(14;16)ELK1repressesR-642-0.0732808Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

amp1qELK1repressesR-642-0.0732808Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ASXL3ELK1activatesR-6360.485452Pr-0
MAGI1ELK1activatesR-6360.485452Pr-0
NEBELK1activatesR-6360.485452Pr-0
t(11;14)ELK1activatesR-6360.485452Pr-0
TACC2ELK1activatesR-6360.485452Pr-0
del13ELK1activatesR-6360.485452Pr-0
NEBELK1repressesR-6480.765153Pr-99
t(11;14)ELK1repressesR-6480.765153Pr-99
TACC2ELK1repressesR-6480.765153Pr-99
amp1qELK1repressesR-638-0.772695Pr-136
del1pELK1repressesR-638-0.772695Pr-136
ASXL3ELK1activatesR-647-0.775241Pr-0
NEBELK1activatesR-647-0.775241Pr-0
amp1qELK1activatesR-647-0.775241Pr-0
del13ELK1activatesR-647-0.775241Pr-0
RNASeq_MAFA_CallELK1repressesR-6410.884722Pr-58
t(14;16)ELK1repressesR-6410.884722Pr-58
amp1qELK1repressesR-6410.884722Pr-58
del13ELK1repressesR-6410.884722Pr-58
ASXL3ELK1activatesR-6391.02155Pr-13
NEBELK1activatesR-6391.02155Pr-13
TACC2ELK1activatesR-6391.02155Pr-13
amp1qELK1activatesR-6391.02155Pr-13
del13ELK1activatesR-6391.02155Pr-13
del1pELK1activatesR-6391.02155Pr-13
t(11;14)ELK1repressesR-643-1.13835Pr-117
t(14;16)ELK1repressesR-643-1.13835Pr-117
amp1qELK1repressesR-643-1.13835Pr-117
del13ELK1repressesR-643-1.13835Pr-117
del1pELK1repressesR-643-1.13835Pr-117
t(14;16)ELK1repressesR-654-1.31124Pr-59
TACC2ELK1repressesR-654-1.31124Pr-59
amp1qELK1repressesR-654-1.31124Pr-59
del13ELK1repressesR-654-1.31124Pr-59
del1pELK1repressesR-654-1.31124Pr-59
t(11;14)ELK1repressesR-646-1.39527Pr-37
t(14;16)ELK1repressesR-646-1.39527Pr-37
amp1qELK1repressesR-646-1.39527Pr-37
del13ELK1repressesR-646-1.39527Pr-37
NEBELK1repressesR-640-1.46197Pr-99
t(11;14)ELK1repressesR-640-1.46197Pr-99
t(14;16)ELK1repressesR-640-1.46197Pr-99
amp1qELK1repressesR-640-1.46197Pr-99
del13ELK1repressesR-640-1.46197Pr-99
t(11;14)ELK1activatesR-651-1.70669Pr-6
t(14;16)ELK1activatesR-651-1.70669Pr-6
TACC2ELK1activatesR-651-1.70669Pr-6
amp1qELK1activatesR-651-1.70669Pr-6
del13ELK1activatesR-651-1.70669Pr-6
t(11;14)ELK1repressesR-6502.0246Pr-99
TACC2ELK1repressesR-6502.0246Pr-99
del13ELK1repressesR-6502.0246Pr-99
t(11;14)ELK1repressesR-655-2.04259Pr-38
t(14;16)ELK1repressesR-655-2.04259Pr-38
amp1qELK1repressesR-655-2.04259Pr-38
del13ELK1repressesR-655-2.04259Pr-38
t(11;14)ELK1activatesR-6492.08583Pr-96
RNASeq_MAFA_CallELK1activatesR-6492.08583Pr-96
t(14;16)ELK1activatesR-6492.08583Pr-96
amp1qELK1activatesR-6492.08583Pr-96
del13ELK1activatesR-6492.08583Pr-96
t(14;16)ELK1repressesR-652-2.32781Pr-37
amp1qELK1repressesR-652-2.32781Pr-37
del13ELK1repressesR-652-2.32781Pr-37
del1pELK1repressesR-652-2.32781Pr-37
t(14;16)ELK1repressesR-637-3.07213Pr-61
amp1qELK1repressesR-637-3.07213Pr-61
del13ELK1repressesR-637-3.07213Pr-61
RNASeq_MAFA_CallELK1repressesR-653-4.70853Pr-61
t(14;16)ELK1repressesR-653-4.70853Pr-61
amp1qELK1repressesR-653-4.70853Pr-61
t(14;16)ELK1activatesR-6358.4777Pr-68
del1pELK1activatesR-6358.4777Pr-68

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.