Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

SRF - serum response factor

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
6722 ENSG00000112658 SRF P11831

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: SRF

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2SRFactivatesR-1790-1.04379Pr-27
DNAH10SRFactivatesR-1790-1.04379Pr-27
MXRA5SRFactivatesR-1790-1.04379Pr-27
PRKD2SRFactivatesR-1790-1.04379Pr-27
t(11;14)SRFactivatesR-1790-1.04379Pr-27
MYCSRFactivatesR-1790-1.04379Pr-27
TP53SRFactivatesR-1790-1.04379Pr-27
AHNAK2SRFactivatesR-1789-1.22568Pr-1
RNASeq_FGFR3_CallSRFactivatesR-1789-1.22568Pr-1
t(4;14)SRFactivatesR-1789-1.22568Pr-1
DNAH10SRFrepressesR-17841.54282Pr-127
FAM46CSRFrepressesR-17841.54282Pr-127
IRF4SRFrepressesR-17841.54282Pr-127
MXRA5SRFrepressesR-17841.54282Pr-127
PRKD2SRFrepressesR-17841.54282Pr-127
t(11;14)SRFrepressesR-17841.54282Pr-127
RNASeq_FGFR3_CallSRFrepressesR-17841.54282Pr-127
MYCSRFrepressesR-17841.54282Pr-127
t(4;14)SRFrepressesR-17841.54282Pr-127
SETD2SRFrepressesR-17841.54282Pr-127
TP53SRFrepressesR-17841.54282Pr-127
DIS3SRFactivatesR-1788-1.83514Pr-118
DNAH10SRFactivatesR-1788-1.83514Pr-118
FAM46CSRFactivatesR-1788-1.83514Pr-118
FRAS1SRFactivatesR-1788-1.83514Pr-118
IRF4SRFactivatesR-1788-1.83514Pr-118
PRKD2SRFactivatesR-1788-1.83514Pr-118
t(11;14)SRFactivatesR-1788-1.83514Pr-118
RNASeq_FGFR3_CallSRFactivatesR-1788-1.83514Pr-118
t(14;16)SRFactivatesR-1788-1.83514Pr-118
t(4;14)SRFactivatesR-1788-1.83514Pr-118
AHNAK2SRFactivatesR-1778-2.26549Pr-4
DIS3SRFactivatesR-1778-2.26549Pr-4
FAM46CSRFactivatesR-1778-2.26549Pr-4
FAT3SRFactivatesR-1778-2.26549Pr-4
MACF1SRFactivatesR-1778-2.26549Pr-4
t(11;14)SRFactivatesR-1778-2.26549Pr-4
RNASeq_FGFR3_CallSRFactivatesR-1778-2.26549Pr-4
RNASeq_MAFA_CallSRFactivatesR-1778-2.26549Pr-4
RNASeq_MAFB_CallSRFactivatesR-1778-2.26549Pr-4
t(4;14)SRFactivatesR-1778-2.26549Pr-4
SETD2SRFactivatesR-1778-2.26549Pr-4
SYNE1SRFactivatesR-1778-2.26549Pr-4
TACC2SRFactivatesR-1778-2.26549Pr-4
FRAS1SRFrepressesR-17862.43898Pr-117
IRF4SRFrepressesR-17862.43898Pr-117
MXRA5SRFrepressesR-17862.43898Pr-117
t(11;14)SRFrepressesR-17862.43898Pr-117
MYCSRFrepressesR-17862.43898Pr-117
SYNE1SRFrepressesR-17862.43898Pr-117
TP53SRFrepressesR-17862.43898Pr-117
ZNF462SRFrepressesR-17862.43898Pr-117
DIS3SRFactivatesR-1783-2.52212Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

FAM46CSRFactivatesR-1783-2.52212Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

FAT3SRFactivatesR-1783-2.52212Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

PRKD2SRFactivatesR-1783-2.52212Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

t(11;14)SRFactivatesR-1783-2.52212Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

RNASeq_FGFR3_CallSRFactivatesR-1783-2.52212Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

t(4;14)SRFactivatesR-1783-2.52212Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

DIS3SRFactivatesR-1782-2.52908Pr-15
FAT3SRFactivatesR-1782-2.52908Pr-15
IRF4SRFactivatesR-1782-2.52908Pr-15
PRKD2SRFactivatesR-1782-2.52908Pr-15
t(11;14)SRFactivatesR-1782-2.52908Pr-15
RNASeq_FGFR3_CallSRFactivatesR-1782-2.52908Pr-15
t(4;14)SRFactivatesR-1782-2.52908Pr-15
DIS3SRFactivatesR-1779-3.05603Pr-36
FAM46CSRFactivatesR-1779-3.05603Pr-36
FRAS1SRFactivatesR-1779-3.05603Pr-36
IRF4SRFactivatesR-1779-3.05603Pr-36
PRKD2SRFactivatesR-1779-3.05603Pr-36
t(11;14)SRFactivatesR-1779-3.05603Pr-36
RNASeq_FGFR3_CallSRFactivatesR-1779-3.05603Pr-36
RNASeq_MAFA_CallSRFactivatesR-1779-3.05603Pr-36
RNASeq_MAFB_CallSRFactivatesR-1779-3.05603Pr-36
t(14;16)SRFactivatesR-1779-3.05603Pr-36
t(4;14)SRFactivatesR-1779-3.05603Pr-36
DIS3SRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FAM46CSRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

PRKD2SRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(11;14)SRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_FGFR3_CallSRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFA_CallSRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

RNASeq_MAFB_CallSRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(14;16)SRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

t(4;14)SRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

TP53SRFrepressesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

AHNAK2SRFrepressesR-17814.13916Pr-70
DIS3SRFrepressesR-17814.13916Pr-70
FAM46CSRFrepressesR-17814.13916Pr-70
FAT3SRFrepressesR-17814.13916Pr-70
IRF4SRFrepressesR-17814.13916Pr-70
MACF1SRFrepressesR-17814.13916Pr-70
t(11;14)SRFrepressesR-17814.13916Pr-70
RNASeq_FGFR3_CallSRFrepressesR-17814.13916Pr-70
RNASeq_MAFA_CallSRFrepressesR-17814.13916Pr-70
RNASeq_MAFB_CallSRFrepressesR-17814.13916Pr-70
t(14;16)SRFrepressesR-17814.13916Pr-70
t(4;14)SRFrepressesR-17814.13916Pr-70
SYNE1SRFrepressesR-17814.13916Pr-70
TACC2SRFrepressesR-17814.13916Pr-70
TP53SRFrepressesR-17814.13916Pr-70
ZNF462SRFrepressesR-17814.13916Pr-70
DIS3SRFrepressesR-17854.55548Pr-63
DNAH10SRFrepressesR-17854.55548Pr-63
IRF4SRFrepressesR-17854.55548Pr-63
MXRA5SRFrepressesR-17854.55548Pr-63
PRKD2SRFrepressesR-17854.55548Pr-63
t(11;14)SRFrepressesR-17854.55548Pr-63
RNASeq_FGFR3_CallSRFrepressesR-17854.55548Pr-63
TP53SRFrepressesR-17854.55548Pr-63
DIS3SRFactivatesR-1787-5.29074Pr-104
DNAH10SRFactivatesR-1787-5.29074Pr-104
FAM46CSRFactivatesR-1787-5.29074Pr-104
FRAS1SRFactivatesR-1787-5.29074Pr-104
IRF4SRFactivatesR-1787-5.29074Pr-104
MXRA5SRFactivatesR-1787-5.29074Pr-104
t(11;14)SRFactivatesR-1787-5.29074Pr-104
RNASeq_MAFA_CallSRFactivatesR-1787-5.29074Pr-104
RNASeq_MAFB_CallSRFactivatesR-1787-5.29074Pr-104
t(14;16)SRFactivatesR-1787-5.29074Pr-104
MYCSRFactivatesR-1787-5.29074Pr-104
TP53SRFactivatesR-1787-5.29074Pr-104
ZNF462SRFactivatesR-1787-5.29074Pr-104
DIS3SRFrepressesR-17807.20867Pr-71
DNAH10SRFrepressesR-17807.20867Pr-71
FAM46CSRFrepressesR-17807.20867Pr-71
FAT3SRFrepressesR-17807.20867Pr-71
FRAS1SRFrepressesR-17807.20867Pr-71
IRF4SRFrepressesR-17807.20867Pr-71
PRKD2SRFrepressesR-17807.20867Pr-71
t(11;14)SRFrepressesR-17807.20867Pr-71
RNASeq_FGFR3_CallSRFrepressesR-17807.20867Pr-71
t(14;16)SRFrepressesR-17807.20867Pr-71
t(4;14)SRFrepressesR-17807.20867Pr-71
TP53SRFrepressesR-17807.20867Pr-71

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.