Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

- fibroblast growth factor 9

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
ENSG00000102678 A0A7U3L6D0

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator:

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
DIS3activatesR-2312.54104Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

FGFR3activatesR-2312.54104Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

NRASactivatesR-2312.54104Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

PRKD2activatesR-2312.54104Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RNASeq_FGFR3_CallactivatesR-2312.54104Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(4;14)activatesR-2312.54104Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

del13activatesR-2312.54104Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

t(4;14)_cytogeneticactivatesR-2312.54104Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

COL6A5activatesR-2333.06438Pr-8
DIS3activatesR-2333.06438Pr-8
FGFR3activatesR-2333.06438Pr-8
PRKD2activatesR-2333.06438Pr-8
RNASeq_FGFR3_CallactivatesR-2333.06438Pr-8
t(4;14)activatesR-2333.06438Pr-8
amp1qactivatesR-2333.06438Pr-8
del13activatesR-2333.06438Pr-8
t(4;14)_cytogeneticactivatesR-2333.06438Pr-8
COL6A5activatesR-2304.32272Pr-8
DIS3activatesR-2304.32272Pr-8
FGFR3activatesR-2304.32272Pr-8
RNASeq_FGFR3_CallactivatesR-2304.32272Pr-8
t(4;14)activatesR-2304.32272Pr-8
amp1qactivatesR-2304.32272Pr-8
t(4;14)_cytogeneticactivatesR-2304.32272Pr-8
DIS3activatesR-2325.31311Pr-108
DNAH10activatesR-2325.31311Pr-108
FGFR3activatesR-2325.31311Pr-108
LTBactivatesR-2325.31311Pr-108
MUC16activatesR-2325.31311Pr-108
MYH2activatesR-2325.31311Pr-108
NRASactivatesR-2325.31311Pr-108
PRKD2activatesR-2325.31311Pr-108
RNASeq_FGFR3_CallactivatesR-2325.31311Pr-108
t(4;14)activatesR-2325.31311Pr-108
amp1qactivatesR-2325.31311Pr-108
del13activatesR-2325.31311Pr-108
t(4;14)_cytogeneticactivatesR-2325.31311Pr-108

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.