Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

NR2F6 - nuclear receptor subfamily 2 group F member 6

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
2063 ENSG00000160113 NR2F6 F1D8R3

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: NR2F6

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
RNASeq_MAFA_CallNR2F6repressesR-13820.010612Pr-41
RNASeq_MAFB_CallNR2F6repressesR-13820.010612Pr-41
t(14;16)NR2F6repressesR-13820.010612Pr-41
t(11;14)NR2F6activatesR-1380-1.33754Pr-102
RNASeq_FGFR3_CallNR2F6repressesR-1376-1.39889Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

t(4;14)NR2F6repressesR-1376-1.39889Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

DNAH10NR2F6repressesR-13781.48043Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

HUWE1NR2F6repressesR-13781.48043Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)NR2F6repressesR-13781.48043Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

t(11;14)_cytogeneticNR2F6repressesR-13781.48043Pr-132

Genes (3)

CHRM4, MAP3K3, BCKDHA

Regulons (7)

R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197

FGFR3NR2F6repressesR-13752.34002Pr-123
IRF4NR2F6repressesR-13752.34002Pr-123
PRKD2NR2F6repressesR-13752.34002Pr-123
t(11;14)NR2F6repressesR-13752.34002Pr-123
RNASeq_FGFR3_CallNR2F6repressesR-13752.34002Pr-123
t(4;14)NR2F6repressesR-13752.34002Pr-123
SVILNR2F6repressesR-13752.34002Pr-123
del13NR2F6repressesR-13752.34002Pr-123
t(11;14)_cytogeneticNR2F6repressesR-13752.34002Pr-123
t(4;14)_cytogeneticNR2F6repressesR-13752.34002Pr-123
ACTG1NR2F6activatesR-1377-3.229Pr-137
DSTNR2F6activatesR-1377-3.229Pr-137
RNASeq_CCND2_CallNR2F6activatesR-1377-3.229Pr-137
RNASeq_MAFA_CallNR2F6activatesR-1377-3.229Pr-137
RNASeq_MAFB_CallNR2F6activatesR-1377-3.229Pr-137
t(14;16)NR2F6activatesR-1377-3.229Pr-137
del13NR2F6activatesR-1377-3.229Pr-137
FGFR3NR2F6activatesR-1379-4.31321Pr-118
IRF4NR2F6activatesR-1379-4.31321Pr-118
t(11;14)NR2F6activatesR-1379-4.31321Pr-118
RNASeq_FGFR3_CallNR2F6activatesR-1379-4.31321Pr-118
RNASeq_MAFA_CallNR2F6activatesR-1379-4.31321Pr-118
t(4;14)NR2F6activatesR-1379-4.31321Pr-118
t(11;14)_cytogeneticNR2F6activatesR-1379-4.31321Pr-118
t(4;14)_cytogeneticNR2F6activatesR-1379-4.31321Pr-118
DNAH10NR2F6activatesR-1381-4.38369Pr-42
FGFR3NR2F6activatesR-1381-4.38369Pr-42
HUWE1NR2F6activatesR-1381-4.38369Pr-42
IRF4NR2F6activatesR-1381-4.38369Pr-42
PRKD2NR2F6activatesR-1381-4.38369Pr-42
t(11;14)NR2F6activatesR-1381-4.38369Pr-42
RNASeq_FGFR3_CallNR2F6activatesR-1381-4.38369Pr-42
RNASeq_MAFA_CallNR2F6activatesR-1381-4.38369Pr-42
RNASeq_MAFB_CallNR2F6activatesR-1381-4.38369Pr-42
t(14;16)NR2F6activatesR-1381-4.38369Pr-42
MYCNR2F6activatesR-1381-4.38369Pr-42
t(4;14)NR2F6activatesR-1381-4.38369Pr-42
t(11;14)_cytogeneticNR2F6activatesR-1381-4.38369Pr-42
t(4;14)_cytogeneticNR2F6activatesR-1381-4.38369Pr-42

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.