Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation SETD2

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
FLI1down-regulatesR-7820.152239Pr-137
CEBPBup-regulatesR-1768-0.337185Pr-109
RREB1down-regulatesR-2284-0.436433Pr-14
SPDEFdown-regulatesR-1972-0.517954Pr-109
MAZup-regulatesR-5070.537629Pr-129
MEF2Adown-regulatesR-18860.552959Pr-129
HSF1down-regulatesR-50-0.599033Pr-16
CEBPBup-regulatesR-1767-0.661208Pr-4
RREB1down-regulatesR-2296-0.757232Pr-9
MAFBdown-regulatesR-1730-0.820291Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

CEBPBup-regulatesR-1777-0.838666Pr-129
PARP1up-regulatesR-2640-0.846126Pr-136
HSF1down-regulatesR-52-0.875962Pr-9
ERFdown-regulatesR-3370.913173Pr-135
ERFdown-regulatesR-3310.969151Pr-136
CEBPBup-regulatesR-17621.16852Pr-127
SRFdown-regulatesR-17841.54282Pr-127
MAZup-regulatesR-511-1.75904Pr-0
HSF1down-regulatesR-56-1.77472Pr-36
ATF1up-regulatesR-560-1.81953Pr-4
PPARGdown-regulatesR-2826-1.9597Pr-35
SPDEFdown-regulatesR-19641.96106Pr-127
ATF5up-regulatesR-2405-2.17053Pr-109
FLI1down-regulatesR-7842.19671Pr-137
SRFdown-regulatesR-1778-2.26549Pr-4
TCF7L1down-regulatesR-3170-2.27892Pr-14
ERFdown-regulatesR-3352.46806Pr-136
FOXO3down-regulatesR-2767-2.51658Pr-4
ENSG00000176887up-regulatesR-1898-2.61611Pr-36
FLI1down-regulatesR-7952.77664Pr-50
NFIL3down-regulatesR-1684-2.82079Pr-4
ENSG00000175832up-regulatesR-313-2.85877Pr-101
MAZup-regulatesR-513-2.96542Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

ENSG00000175832up-regulatesR-312-3.06Pr-36
MEF2Adown-regulatesR-1877-3.20022Pr-38
MZF1down-regulatesR-3018-3.24499Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FOXO3down-regulatesR-2771-3.30433Pr-100
FOXO3down-regulatesR-2773-3.37313Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

MEF2Adown-regulatesR-1868-3.37401Pr-100
MZF1down-regulatesR-3019-3.42244Pr-35
RREB1down-regulatesR-2292-3.46394Pr-101
MAZup-regulatesR-512-3.50135Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

CEBPBup-regulatesR-1775-3.79192Pr-36
CEBPBup-regulatesR-1774-3.92486Pr-38
MAZup-regulatesR-509-4.01621Pr-42
CEBPBup-regulatesR-17724.02047Pr-122
RREB1down-regulatesR-2287-4.14495Pr-100
ERFdown-regulatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

SPDEFdown-regulatesR-1963-4.23229Pr-35
MEF2Adown-regulatesR-18804.46094Pr-128
ENSG00000176887up-regulatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FLI1down-regulatesR-794-4.49758Pr-36
RREB1down-regulatesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MEF2Adown-regulatesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-506-4.85353Pr-4
MAZup-regulatesR-4974.96461Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MZF1down-regulatesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions