Program

Causal Mechanistic Flows with regulons in program Pr-54

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
FAM46Cup-regulatesENSG00000168269activatesR-1569-0.6229269Pr-54
PTPRDdown-regulatesENSG00000168269activatesR-1569-0.6229269Pr-54
t(11;14)down-regulatesENSG00000168269activatesR-1569-0.6229269Pr-54
RNASeq_MAFB_Calldown-regulatesENSG00000168269activatesR-1569-0.6229269Pr-54
t(4;14)up-regulatesENSG00000168269activatesR-1569-0.6229269Pr-54
t(11;14)_cytogeneticdown-regulatesENSG00000168269activatesR-1569-0.6229269Pr-54
DIS3up-regulatesRFX1activatesR-25681.63559Pr-54
FGFR3up-regulatesRFX1activatesR-25681.63559Pr-54
RNASeq_FGFR3_Callup-regulatesRFX1activatesR-25681.63559Pr-54
t(4;14)up-regulatesRFX1activatesR-25681.63559Pr-54
amp1qup-regulatesRFX1activatesR-25681.63559Pr-54
del13up-regulatesRFX1activatesR-25681.63559Pr-54
t(4;14)_cytogeneticup-regulatesRFX1activatesR-25681.63559Pr-54
CSMD3up-regulatesCEBPZrepressesR-7581.766046Pr-54
KMT2Bup-regulatesCEBPZrepressesR-7581.766046Pr-54
MXRA5up-regulatesCEBPZrepressesR-7581.766046Pr-54
t(11;14)down-regulatesCEBPZrepressesR-7581.766046Pr-54
MYCup-regulatesCEBPZrepressesR-7581.766046Pr-54
TP53up-regulatesCEBPZrepressesR-7581.766046Pr-54
DIS3up-regulatesZFXactivatesR-19301.794896Pr-54
FGFR3up-regulatesZFXactivatesR-19301.794896Pr-54
t(11;14)up-regulatesZFXactivatesR-19301.794896Pr-54
RNASeq_FGFR3_Callup-regulatesZFXactivatesR-19301.794896Pr-54
MYCdown-regulatesZFXactivatesR-19301.794896Pr-54
t(4;14)up-regulatesZFXactivatesR-19301.794896Pr-54
t(4;14)_cytogeneticup-regulatesZFXactivatesR-19301.794896Pr-54
BAI3down-regulatesPLAG1activatesR-15273.75567Pr-54
FRAS1down-regulatesPLAG1activatesR-15273.75567Pr-54
KDM3Bdown-regulatesPLAG1activatesR-15273.75567Pr-54
t(11;14)down-regulatesPLAG1activatesR-15273.75567Pr-54
t(14;16)down-regulatesPLAG1activatesR-15273.75567Pr-54
t(11;14)_cytogeneticdown-regulatesPLAG1activatesR-15273.75567Pr-54
DCHS1up-regulatesSP1activatesR-27126.5488636Pr-54
DIS3up-regulatesSP1activatesR-27126.5488636Pr-54
FAM46Cdown-regulatesSP1activatesR-27126.5488636Pr-54
FAT3up-regulatesSP1activatesR-27126.5488636Pr-54
FGFR3up-regulatesSP1activatesR-27126.5488636Pr-54
IRF4up-regulatesSP1activatesR-27126.5488636Pr-54
RNASeq_FGFR3_Callup-regulatesSP1activatesR-27126.5488636Pr-54
t(14;16)up-regulatesSP1activatesR-27126.5488636Pr-54
t(4;14)up-regulatesSP1activatesR-27126.5488636Pr-54
TRIOup-regulatesSP1activatesR-27126.5488636Pr-54
amp1qup-regulatesSP1activatesR-27126.5488636Pr-54
t(4;14)_cytogeneticup-regulatesSP1activatesR-27126.5488636Pr-54

Regulons in program Pr-54

Regulon Cox Hazard Ratio # genes # causal flows
R-1569-0.62292696
R-25681.635597
R-7581.7660466
R-19301.7948967
R-15273.755676
R-27126.548863612

Genes in program Pr-54

EnsEMBL IdEntrez IdPreferred
ENSG00000183323 202243CCDC125
ENSG00000205302 6643SNX2
ENSG00000213865 56260C8orf44
ENSG00000214215 338809C12orf74

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions