Program

Causal Mechanistic Flows with regulons in program Pr-26

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DIS3up-regulatesENSG00000165066repressesR-3078-0.79113711Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

IRF4up-regulatesENSG00000165066repressesR-3078-0.79113711Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)up-regulatesENSG00000165066repressesR-3078-0.79113711Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

RNASeq_FGFR3_Calldown-regulatesENSG00000165066repressesR-3078-0.79113711Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(4;14)down-regulatesENSG00000165066repressesR-3078-0.79113711Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)_cytogeneticup-regulatesENSG00000165066repressesR-3078-0.79113711Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

DIS3down-regulatesHIVEP2activatesR-1915-1.985976Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)down-regulatesHIVEP2activatesR-1915-1.985976Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

RNASeq_FGFR3_Calldown-regulatesHIVEP2activatesR-1915-1.985976Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

MYCdown-regulatesBCL6activatesR-551-2.963159Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

KDM3Bdown-regulatesSOX4activatesR-2188-3.255067Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)down-regulatesSOX4activatesR-2188-3.255067Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)_cytogeneticdown-regulatesSOX4activatesR-2188-3.255067Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

DIS3up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

DNAH10up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

FAT3up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

IRF4up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

MACF1up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

PRKD2up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

RNASeq_FGFR3_Callup-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(14;16)up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(4;14)up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

TP53up-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)_cytogeneticup-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(14;16)_cytogeneticup-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(4;14)_cytogeneticup-regulatesBRCA1repressesR-1030-3.45528Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

AHNAK2up-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

DIS3up-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

FAM46Cdown-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

PRKD2up-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

RNASeq_FGFR3_Callup-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(4;14)up-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

SETD2up-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

TP53up-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(4;14)_cytogeneticup-regulatesMAZrepressesR-512-3.501356Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

RNASeq_FGFR3_Calldown-regulatesSPI1activatesR-2604-4.3095733Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

MYCdown-regulatesSPI1activatesR-2604-4.3095733Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(4;14)down-regulatesSPI1activatesR-2604-4.3095733Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

SYNE1down-regulatesSPI1activatesR-2604-4.3095733Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

Regulons in program Pr-26

Regulon Cox Hazard Ratio # genes # causal flows
R-3078-0.791137116
R-1915-1.9859763
R-551-2.9631591
R-2188-3.2550673
R-1030-3.4552814
R-512-3.5013569
R-2604-4.30957334

Genes in program Pr-26

EnsEMBL IdEntrez IdPreferred
ENSG00000185347 283643TEDC1
ENSG00000229809 146542ZNF688

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions