Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

- GATA binding protein 4

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
ENSG00000136574 R4GND5

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator:

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
KDM3BrepressesR-391.25412Pr-124
MAXrepressesR-391.25412Pr-124
t(11;14)repressesR-391.25412Pr-124
RNASeq_FGFR3_CallrepressesR-391.25412Pr-124
t(4;14)repressesR-391.25412Pr-124
t(11;14)_cytogeneticrepressesR-391.25412Pr-124
t(4;14)_cytogeneticrepressesR-391.25412Pr-124
CYLDrepressesR-36-2.24791Pr-15
FGFR3repressesR-36-2.24791Pr-15
MAXrepressesR-36-2.24791Pr-15
PRKD2repressesR-36-2.24791Pr-15
RNASeq_FGFR3_CallrepressesR-36-2.24791Pr-15
RNASeq_MAFA_CallrepressesR-36-2.24791Pr-15
t(14;16)repressesR-36-2.24791Pr-15
t(4;14)repressesR-36-2.24791Pr-15
ROBO1repressesR-36-2.24791Pr-15
t(4;14)_cytogeneticrepressesR-36-2.24791Pr-15
CYLDrepressesR-33-2.57564Pr-86
MAXrepressesR-33-2.57564Pr-86
NFKB2repressesR-33-2.57564Pr-86
RNASeq_MAFA_CallrepressesR-33-2.57564Pr-86
t(14;16)repressesR-33-2.57564Pr-86
ROBO1repressesR-33-2.57564Pr-86
BAI3activatesR-353.65653Pr-123
CYLDactivatesR-353.65653Pr-123
FGFR3activatesR-353.65653Pr-123
KDM3BactivatesR-353.65653Pr-123
LTBactivatesR-353.65653Pr-123
NRASactivatesR-353.65653Pr-123
PRKD2activatesR-353.65653Pr-123
RNASeq_FGFR3_CallactivatesR-353.65653Pr-123
t(4;14)activatesR-353.65653Pr-123
del13activatesR-353.65653Pr-123
t(4;14)_cytogeneticactivatesR-353.65653Pr-123
CYLDactivatesR-343.74664Pr-108
DUSP2activatesR-343.74664Pr-108
FAT1activatesR-343.74664Pr-108
FGFR3activatesR-343.74664Pr-108
GPR98activatesR-343.74664Pr-108
LTBactivatesR-343.74664Pr-108
MAXactivatesR-343.74664Pr-108
MYH2activatesR-343.74664Pr-108
NRASactivatesR-343.74664Pr-108
PRKD2activatesR-343.74664Pr-108
RNASeq_FGFR3_CallactivatesR-343.74664Pr-108
t(4;14)activatesR-343.74664Pr-108
ROBO1activatesR-343.74664Pr-108
del13activatesR-343.74664Pr-108
t(4;14)_cytogeneticactivatesR-343.74664Pr-108
FGFR3activatesR-384.6199Pr-50
RNASeq_FGFR3_CallactivatesR-384.6199Pr-50
t(4;14)activatesR-384.6199Pr-50
t(4;14)_cytogeneticactivatesR-384.6199Pr-50
FGFR3activatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAXactivatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

NRASactivatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(11;14)activatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

RNASeq_FGFR3_CallactivatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)activatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

del13activatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(11;14)_cytogeneticactivatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

t(4;14)_cytogeneticactivatesR-374.656Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.