Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ERF - ETS2 repressor factor

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
2077 ENSG00000105722 ERF P50548

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ERF

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2ERFactivatesR-3360.343262Pr-35
DIS3ERFactivatesR-3360.343262Pr-35
FAM46CERFactivatesR-3360.343262Pr-35
MACF1ERFactivatesR-3360.343262Pr-35
MAXERFactivatesR-3360.343262Pr-35
NRASERFactivatesR-3360.343262Pr-35
PTPRDERFactivatesR-3360.343262Pr-35
RNASeq_FGFR3_CallERFactivatesR-3360.343262Pr-35
t(4;14)ERFactivatesR-3360.343262Pr-35
t(4;14)_cytogeneticERFactivatesR-3360.343262Pr-35
FAT3ERFrepressesR-3370.913173Pr-135
MACF1ERFrepressesR-3370.913173Pr-135
RNASeq_MAFA_CallERFrepressesR-3370.913173Pr-135
SETD2ERFrepressesR-3370.913173Pr-135
SYNE1ERFrepressesR-3370.913173Pr-135
TACC2ERFrepressesR-3370.913173Pr-135
del13ERFrepressesR-3370.913173Pr-135
t(14;16)_cytogeneticERFrepressesR-3370.913173Pr-135
AHNAK2ERFrepressesR-3310.969151Pr-136
DCHS1ERFrepressesR-3310.969151Pr-136
FAT3ERFrepressesR-3310.969151Pr-136
MACF1ERFrepressesR-3310.969151Pr-136
MAGI1ERFrepressesR-3310.969151Pr-136
MAXERFrepressesR-3310.969151Pr-136
NRASERFrepressesR-3310.969151Pr-136
PTPRDERFrepressesR-3310.969151Pr-136
RNASeq_FGFR3_CallERFrepressesR-3310.969151Pr-136
RNASeq_MAFA_CallERFrepressesR-3310.969151Pr-136
t(4;14)ERFrepressesR-3310.969151Pr-136
SETD2ERFrepressesR-3310.969151Pr-136
SYNE1ERFrepressesR-3310.969151Pr-136
TACC2ERFrepressesR-3310.969151Pr-136
t(14;16)_cytogeneticERFrepressesR-3310.969151Pr-136
t(4;14)_cytogeneticERFrepressesR-3310.969151Pr-136
AHNAK2ERFactivatesR-333-1.22378Pr-3
KALRNERFactivatesR-333-1.22378Pr-3
MACF1ERFactivatesR-333-1.22378Pr-3
MAXERFactivatesR-333-1.22378Pr-3
MYO10ERFactivatesR-333-1.22378Pr-3
RNASeq_MAFA_CallERFactivatesR-333-1.22378Pr-3
SYNE1ERFactivatesR-333-1.22378Pr-3
TACC2ERFactivatesR-333-1.22378Pr-3
del13ERFactivatesR-333-1.22378Pr-3
t(14;16)_cytogeneticERFactivatesR-333-1.22378Pr-3
AHNAK2ERFrepressesR-3352.46806Pr-136
FAT3ERFrepressesR-3352.46806Pr-136
MACF1ERFrepressesR-3352.46806Pr-136
MAXERFrepressesR-3352.46806Pr-136
NRASERFrepressesR-3352.46806Pr-136
RNASeq_MAFA_CallERFrepressesR-3352.46806Pr-136
t(4;14)ERFrepressesR-3352.46806Pr-136
SETD2ERFrepressesR-3352.46806Pr-136
t(14;16)_cytogeneticERFrepressesR-3352.46806Pr-136
DIS3ERFactivatesR-329-2.5417Pr-36
FAM46CERFactivatesR-329-2.5417Pr-36
MAXERFactivatesR-329-2.5417Pr-36
NRASERFactivatesR-329-2.5417Pr-36
RNASeq_FGFR3_CallERFactivatesR-329-2.5417Pr-36
RNASeq_MAFA_CallERFactivatesR-329-2.5417Pr-36
RNASeq_MAFB_CallERFactivatesR-329-2.5417Pr-36
t(4;14)ERFactivatesR-329-2.5417Pr-36
t(4;14)_cytogeneticERFactivatesR-329-2.5417Pr-36
DIS3ERFactivatesR-330-2.95847Pr-101
FAM46CERFactivatesR-330-2.95847Pr-101
FAT3ERFactivatesR-330-2.95847Pr-101
MAXERFactivatesR-330-2.95847Pr-101
NRASERFactivatesR-330-2.95847Pr-101
RNASeq_FGFR3_CallERFactivatesR-330-2.95847Pr-101
RNASeq_MAFA_CallERFactivatesR-330-2.95847Pr-101
RNASeq_MAFB_CallERFactivatesR-330-2.95847Pr-101
t(4;14)ERFactivatesR-330-2.95847Pr-101
t(4;14)_cytogeneticERFactivatesR-330-2.95847Pr-101
DIS3ERFactivatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FAM46CERFactivatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

MACF1ERFactivatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_FGFR3_CallERFactivatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

RNASeq_MAFA_CallERFactivatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)ERFactivatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

SETD2ERFactivatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

t(4;14)_cytogeneticERFactivatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

AHNAK2ERFrepressesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAT3ERFrepressesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MACF1ERFrepressesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MAXERFrepressesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(14;16)_cytogeneticERFrepressesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.