Program

Causal Mechanistic Flows with regulons in program Pr-75

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
CSMD3down-regulatesJUNrepressesR-11820.04086738Pr-75
DIS3up-regulatesJUNrepressesR-11820.04086738Pr-75
MUC16down-regulatesJUNrepressesR-11820.04086738Pr-75
PKHD1L1down-regulatesJUNrepressesR-11820.04086738Pr-75
t(11;14)up-regulatesJUNrepressesR-11820.04086738Pr-75
ROBO1down-regulatesJUNrepressesR-11820.04086738Pr-75
t(11;14)_cytogeneticup-regulatesJUNrepressesR-11820.04086738Pr-75
BRAFup-regulatesJUNrepressesR-11860.7007896Pr-75
CMYA5down-regulatesJUNrepressesR-11860.7007896Pr-75
CSMD3down-regulatesJUNrepressesR-11860.7007896Pr-75
DIS3up-regulatesJUNrepressesR-11860.7007896Pr-75
KIAA1109down-regulatesJUNrepressesR-11860.7007896Pr-75
PKHD1L1down-regulatesJUNrepressesR-11860.7007896Pr-75
t(11;14)up-regulatesJUNrepressesR-11860.7007896Pr-75
TP53down-regulatesJUNrepressesR-11860.7007896Pr-75
t(11;14)_cytogeneticup-regulatesJUNrepressesR-11860.7007896Pr-75
RNASeq_FGFR3_Callup-regulatesZNF281activatesR-24773.2138824Pr-75
t(4;14)up-regulatesZNF281activatesR-24773.2138824Pr-75
amp1qup-regulatesZNF281activatesR-24773.2138824Pr-75
del13up-regulatesZNF281activatesR-24773.2138824Pr-75
KIAA1109up-regulatesZNF410activatesR-19433.344696Pr-75
t(14;16)up-regulatesZNF410activatesR-19433.344696Pr-75
amp1qup-regulatesZNF410activatesR-19433.344696Pr-75
del13up-regulatesZNF410activatesR-19433.344696Pr-75
amp1qdown-regulatesNFE2L2repressesR-19123.3840612Pr-75
del13down-regulatesNFE2L2repressesR-19123.3840612Pr-75
del1pdown-regulatesNFE2L2repressesR-19123.3840612Pr-75
t(11;14)_cytogeneticup-regulatesNFE2L2repressesR-19123.3840612Pr-75
FGFR3up-regulatesPBX1activatesR-21073.6973917Pr-75
NRASdown-regulatesPBX1activatesR-21073.6973917Pr-75
RNASeq_FGFR3_Callup-regulatesPBX1activatesR-21073.6973917Pr-75
t(4;14)up-regulatesPBX1activatesR-21073.6973917Pr-75
amp1qup-regulatesPBX1activatesR-21073.6973917Pr-75
del13up-regulatesPBX1activatesR-21073.6973917Pr-75
t(4;14)_cytogeneticup-regulatesPBX1activatesR-21073.6973917Pr-75
KRASup-regulatesBORCS8-MEF2BrepressesR-9603.767913Pr-75
t(11;14)up-regulatesBORCS8-MEF2BrepressesR-9603.767913Pr-75
RNASeq_CCND3_Callup-regulatesBORCS8-MEF2BrepressesR-9603.767913Pr-75
RNASeq_MAFA_Calldown-regulatesBORCS8-MEF2BrepressesR-9603.767913Pr-75
t(11;14)_cytogeneticup-regulatesBORCS8-MEF2BrepressesR-9603.767913Pr-75
FGFR3up-regulatesTCF4activatesR-29983.9252414Pr-75
LTBup-regulatesTCF4activatesR-29983.9252414Pr-75
NRASdown-regulatesTCF4activatesR-29983.9252414Pr-75
t(11;14)down-regulatesTCF4activatesR-29983.9252414Pr-75
RNASeq_FGFR3_Callup-regulatesTCF4activatesR-29983.9252414Pr-75
t(4;14)up-regulatesTCF4activatesR-29983.9252414Pr-75
TRAF3up-regulatesTCF4activatesR-29983.9252414Pr-75
del13up-regulatesTCF4activatesR-29983.9252414Pr-75
t(11;14)_cytogeneticdown-regulatesTCF4activatesR-29983.9252414Pr-75
t(4;14)_cytogeneticup-regulatesTCF4activatesR-29983.9252414Pr-75

Regulons in program Pr-75

Regulon Cox Hazard Ratio # genes # causal flows
R-11820.040867387
R-11860.70078969
R-24773.21388244
R-19433.3446964
R-19123.38406124
R-21073.69739177
R-9603.7679135
R-29983.925241410

Genes in program Pr-75

EnsEMBL IdEntrez IdPreferred
ENSG00000175602 11007CCDC85B
ENSG00000184436 80764THAP7

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions