Program

Causal Mechanistic Flows with regulons in program Pr-7

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
ATMup-regulatesSREBF1activatesR-11390.1016087Pr-7
MACF1up-regulatesSREBF1activatesR-11390.1016087Pr-7
t(11;14)up-regulatesSREBF1activatesR-11390.1016087Pr-7
RNASeq_MAFA_Callup-regulatesSREBF1activatesR-11390.1016087Pr-7
RNASeq_MAFB_Callup-regulatesSREBF1activatesR-11390.1016087Pr-7
t(14;16)up-regulatesSREBF1activatesR-11390.1016087Pr-7
amp1qup-regulatesSREBF1activatesR-11390.1016087Pr-7
del13up-regulatesSREBF1activatesR-11390.1016087Pr-7
del1pup-regulatesSREBF1activatesR-11390.1016087Pr-7
t(14;16)up-regulatesSTAT3activatesR-308-0.11116710Pr-7
amp1qup-regulatesSTAT3activatesR-308-0.11116710Pr-7
del13up-regulatesSTAT3activatesR-308-0.11116710Pr-7
t(4;14)up-regulatesFOXK1activatesR-11950.15355923Pr-7
amp1qup-regulatesFOXK1activatesR-11950.15355923Pr-7
del13up-regulatesFOXK1activatesR-11950.15355923Pr-7
BRAFup-regulatesZEB1activatesR-22470.27235310Pr-7
PCDH10down-regulatesZEB1activatesR-22470.27235310Pr-7
RNASeq_MAFA_Callup-regulatesZEB1activatesR-22470.27235310Pr-7
t(14;16)up-regulatesZEB1activatesR-22470.27235310Pr-7
amp1qup-regulatesZEB1activatesR-22470.27235310Pr-7
del13up-regulatesZEB1activatesR-22470.27235310Pr-7
del1pup-regulatesZEB1activatesR-22470.27235310Pr-7
DIS3up-regulatesKLF4activatesR-27540.33239611Pr-7
RNASeq_FGFR3_Callup-regulatesKLF4activatesR-27540.33239611Pr-7
t(4;14)up-regulatesKLF4activatesR-27540.33239611Pr-7
amp1qup-regulatesKLF4activatesR-27540.33239611Pr-7
del13up-regulatesKLF4activatesR-27540.33239611Pr-7
PCDH10down-regulatesNFKB1activatesR-15840.4052239Pr-7
t(14;16)up-regulatesZFXactivatesR-19230.5096119Pr-7
WDFY3up-regulatesZFXactivatesR-19230.5096119Pr-7
amp1qup-regulatesZFXactivatesR-19230.5096119Pr-7
del13up-regulatesZFXactivatesR-19230.5096119Pr-7
RNASeq_MAFA_Callup-regulatesFOXJ1activatesR-18490.51975713Pr-7
t(14;16)up-regulatesFOXJ1activatesR-18490.51975713Pr-7
amp1qup-regulatesFOXJ1activatesR-18490.51975713Pr-7
PCDH10down-regulatesELF4activatesR-23450.56513615Pr-7
PRDM1up-regulatesELF4activatesR-23450.56513615Pr-7
t(11;14)up-regulatesELF4activatesR-23450.56513615Pr-7
RNASeq_FGFR3_Callup-regulatesELF4activatesR-23450.56513615Pr-7
t(14;16)up-regulatesELF4activatesR-23450.56513615Pr-7
del1pup-regulatesELF4activatesR-23450.56513615Pr-7
t(11;14)down-regulatesTP53repressesR-3700.5821410Pr-7
RNASeq_FGFR3_Calldown-regulatesTP53repressesR-3700.5821410Pr-7
t(14;16)down-regulatesTP53repressesR-3700.5821410Pr-7
t(4;14)down-regulatesTP53repressesR-3700.5821410Pr-7
amp1qdown-regulatesTP53repressesR-3700.5821410Pr-7
del13down-regulatesTP53repressesR-3700.5821410Pr-7
t(4;14)_cytogeneticdown-regulatesTP53repressesR-3700.5821410Pr-7
HUWE1down-regulatesHOXA3repressesR-226-0.5976127Pr-7
t(11;14)down-regulatesHOXA3repressesR-226-0.5976127Pr-7
t(14;16)down-regulatesHOXA3repressesR-226-0.5976127Pr-7
t(11;14)_cytogeneticdown-regulatesHOXA3repressesR-226-0.5976127Pr-7
NEBdown-regulatesENSG00000054598activatesR-10130.68295515Pr-7
t(11;14)up-regulatesENSG00000054598activatesR-10130.68295515Pr-7
RNASeq_MAFA_Calldown-regulatesTCF3repressesR-20650.68669917Pr-7
t(14;16)down-regulatesTCF3repressesR-20650.68669917Pr-7
RNASeq_FGFR3_Callup-regulatesSOX4activatesR-21810.69622712Pr-7
t(4;14)up-regulatesSOX4activatesR-21810.69622712Pr-7
del13up-regulatesSOX4activatesR-21810.69622712Pr-7
t(11;14)up-regulatesELF3activatesR-21450.72715316Pr-7
amp1qup-regulatesELF3activatesR-21450.72715316Pr-7
del13up-regulatesELF3activatesR-21450.72715316Pr-7
del1pup-regulatesELF3activatesR-21450.72715316Pr-7
t(14;16)up-regulatesBACH2activatesR-28430.7468618Pr-7
amp1qup-regulatesBACH2activatesR-28430.7468618Pr-7
del13up-regulatesBACH2activatesR-28430.7468618Pr-7
del1pup-regulatesBACH2activatesR-28430.7468618Pr-7
MYCdown-regulatesENSG00000054598activatesR-10030.75112628Pr-7
TRAF3down-regulatesENSG00000054598activatesR-10030.75112628Pr-7
t(11;14)up-regulatesFOXO1activatesR-14100.75723415Pr-7
del13up-regulatesFOXO1activatesR-14100.75723415Pr-7
t(11;14)up-regulatesFOSL1activatesR-27960.7802037Pr-7
del1pdown-regulatesZNF691repressesR-30120.7856377Pr-7
t(11;14)down-regulatesARID3ArepressesR-13470.8356789Pr-7
PCDH10down-regulatesFOXP1activatesR-31360.8386314Pr-7
PRDM1up-regulatesFOXP1activatesR-31360.8386314Pr-7
t(11;14)up-regulatesFOXP1activatesR-31360.8386314Pr-7
RNASeq_MAFA_Callup-regulatesFOXP1activatesR-31360.8386314Pr-7
t(14;16)up-regulatesFOXP1activatesR-31360.8386314Pr-7
amp1qup-regulatesFOXP1activatesR-31360.8386314Pr-7
del13up-regulatesFOXP1activatesR-31360.8386314Pr-7
del1pup-regulatesFOXP1activatesR-31360.8386314Pr-7
COL6A5down-regulatesENSG00000245848activatesR-16500.84458412Pr-7
LRP2down-regulatesENSG00000245848activatesR-16500.84458412Pr-7
t(11;14)up-regulatesENSG00000245848activatesR-16500.84458412Pr-7
t(11;14)up-regulatesBCL6activatesR-5430.85914717Pr-7
NEBdown-regulatesHSF1activatesR-530.8611788Pr-7
amp1qup-regulatesHSF1activatesR-530.8611788Pr-7
del13up-regulatesHSF1activatesR-530.8611788Pr-7
t(11;14)up-regulatesRFX1activatesR-25710.8810557Pr-7
amp1qup-regulatesRFX1activatesR-25710.8810557Pr-7
del13up-regulatesRFX1activatesR-25710.8810557Pr-7
t(11;14)_cytogeneticup-regulatesRFX1activatesR-25710.8810557Pr-7
amp1qup-regulatesMEF2AactivatesR-18790.8933219Pr-7
del13up-regulatesMEF2AactivatesR-18790.8933219Pr-7
t(11;14)up-regulatesMAFBactivatesR-17381.0732313Pr-7
PCDH10down-regulatesEWSR1activatesR-25571.1229910Pr-7
t(11;14)up-regulatesEWSR1activatesR-25571.1229910Pr-7
RNASeq_FGFR3_Callup-regulatesEWSR1activatesR-25571.1229910Pr-7
t(14;16)up-regulatesEWSR1activatesR-25571.1229910Pr-7
t(4;14)up-regulatesEWSR1activatesR-25571.1229910Pr-7
amp1qup-regulatesEWSR1activatesR-25571.1229910Pr-7
del13up-regulatesEWSR1activatesR-25571.1229910Pr-7
amp1qup-regulatesSPDEFactivatesR-19681.123098Pr-7
del13up-regulatesSPDEFactivatesR-19681.123098Pr-7
t(4;14)up-regulatesENSG00000168269activatesR-15621.1394420Pr-7
NEBup-regulatesXBP1repressesR-30671.206196Pr-7
RNASeq_MAFA_Calldown-regulatesXBP1repressesR-30671.206196Pr-7
del1pdown-regulatesXBP1repressesR-30671.206196Pr-7
ATMdown-regulatesFLI1repressesR-7881.220519Pr-7
BRAFdown-regulatesFLI1repressesR-7881.220519Pr-7
HUWE1down-regulatesFLI1repressesR-7881.220519Pr-7
t(11;14)down-regulatesFLI1repressesR-7881.220519Pr-7
RNASeq_FGFR3_Calldown-regulatesFLI1repressesR-7881.220519Pr-7
RNASeq_MAFA_Calldown-regulatesFLI1repressesR-7881.220519Pr-7
t(14;16)down-regulatesFLI1repressesR-7881.220519Pr-7
t(4;14)down-regulatesFLI1repressesR-7881.220519Pr-7
amp1qdown-regulatesFLI1repressesR-7881.220519Pr-7
del13down-regulatesFLI1repressesR-7881.220519Pr-7
t(4;14)_cytogeneticdown-regulatesFLI1repressesR-7881.220519Pr-7
NEBdown-regulatesHBP1activatesR-18401.221819Pr-7
PCDH10down-regulatesHBP1activatesR-18401.221819Pr-7
t(11;14)up-regulatesHBP1activatesR-18401.221819Pr-7
amp1qup-regulatesHBP1activatesR-18401.221819Pr-7
del13up-regulatesHBP1activatesR-18401.221819Pr-7
del1pup-regulatesIRX3activatesR-22301.281678Pr-7
BRAFup-regulatesBACH1activatesR-4711.318229Pr-7
t(11;14)up-regulatesBACH1activatesR-4711.318229Pr-7
RNASeq_FGFR3_Callup-regulatesBACH1activatesR-4711.318229Pr-7
t(14;16)up-regulatesBACH1activatesR-4711.318229Pr-7
t(4;14)up-regulatesBACH1activatesR-4711.318229Pr-7
amp1qup-regulatesBACH1activatesR-4711.318229Pr-7
del13up-regulatesBACH1activatesR-4711.318229Pr-7
FGFR3up-regulatesRFX3activatesR-16671.319949Pr-7
NEBdown-regulatesRFX3activatesR-16671.319949Pr-7
t(11;14)up-regulatesRFX3activatesR-16671.319949Pr-7
RNASeq_FGFR3_Callup-regulatesRFX3activatesR-16671.319949Pr-7
t(4;14)up-regulatesRFX3activatesR-16671.319949Pr-7
BRAFup-regulatesHSF2activatesR-31651.49898Pr-7
t(11;14)up-regulatesHSF2activatesR-31651.49898Pr-7
RNASeq_FGFR3_Callup-regulatesHSF2activatesR-31651.49898Pr-7
amp1qup-regulatesHSF2activatesR-31651.49898Pr-7
del13up-regulatesHSF2activatesR-31651.49898Pr-7
FGFR3down-regulatesTP53repressesR-3612.6317718Pr-7
PTPRDup-regulatesTP53repressesR-3612.6317718Pr-7
RNASeq_FGFR3_Calldown-regulatesTP53repressesR-3612.6317718Pr-7
t(14;16)down-regulatesTP53repressesR-3612.6317718Pr-7
MYCup-regulatesTP53repressesR-3612.6317718Pr-7
t(4;14)down-regulatesTP53repressesR-3612.6317718Pr-7
t(4;14)_cytogeneticdown-regulatesTP53repressesR-3612.6317718Pr-7

Regulons in program Pr-7

Regulon Cox Hazard Ratio # genes # causal flows
R-11390.10160879
R-308-0.111167103
R-11950.153559233
R-22470.272353107
R-27540.332396115
R-15840.40522391
R-19230.50961194
R-18490.519757133
R-23450.565136156
R-3700.58214107
R-226-0.59761274
R-10130.682955152
R-20650.686699172
R-21810.696227123
R-21450.727153164
R-28430.74686184
R-10030.751126282
R-14100.757234152
R-27960.78020371
R-30120.78563771
R-13470.83567891
R-31360.83863148
R-16500.844584123
R-5430.859147171
R-530.86117883
R-25710.88105574
R-18790.89332192
R-17381.07323131
R-25571.12299107
R-19681.1230982
R-15621.13944201
R-30671.2061963
R-7881.22051911
R-18401.2218195
R-22301.2816781
R-4711.3182297
R-16671.3199495
R-31651.498985
R-3612.63177187

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions