Program

Causal Mechanistic Flows with regulons in program Pr-67

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
amp1qup-regulatesHSF1repressesR-55-1.277437Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

del13up-regulatesHSF1repressesR-55-1.277437Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

DSTdown-regulatesSATB1activatesR-1075-1.8888513Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

MAXdown-regulatesSATB1activatesR-1075-1.8888513Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

RNASeq_CCND2_Calldown-regulatesSATB1activatesR-1075-1.8888513Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

RNASeq_MAFA_Calldown-regulatesSATB1activatesR-1075-1.8888513Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

AHNAK2down-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

DSTdown-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

LTBdown-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

NRASup-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

RNASeq_FGFR3_Calldown-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(4;14)down-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

TRAF3down-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

amp1qdown-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

del13down-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(4;14)_cytogeneticdown-regulatesIRF7activatesR-1089-2.1019412Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

DSTdown-regulatesELF1activatesR-2987-2.2167310Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

NRASup-regulatesELF1activatesR-2987-2.2167310Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(11;14)up-regulatesELF1activatesR-2987-2.2167310Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

TRAF3down-regulatesELF1activatesR-2987-2.2167310Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(11;14)_cytogeneticup-regulatesELF1activatesR-2987-2.2167310Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

DIS3down-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

MAXdown-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

NRASup-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

RNASeq_FGFR3_Calldown-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(14;16)down-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(4;14)down-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

amp1qdown-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

del13down-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

t(4;14)_cytogeneticdown-regulatesTP53activatesR-375-2.857828Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

Regulons in program Pr-67

Regulon Cox Hazard Ratio # genes # causal flows
R-55-1.2774372
R-1075-1.88885134
R-1089-2.101941210
R-2987-2.21673105
R-375-2.8578289

Genes in program Pr-67

EnsEMBL IdEntrez IdPreferred
ENSG00000197721
ENSG00000221821 441150C6orf226
ENSG00000241553 10093ARPC4
ENSG00000250305 57604TRMT9B

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions