Program

Causal Mechanistic Flows with regulons in program Pr-5

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
DIS3down-regulatesTP53repressesR-3620.002248617Pr-5
FGFR3down-regulatesTP53repressesR-3620.002248617Pr-5
PTPRDup-regulatesTP53repressesR-3620.002248617Pr-5
t(11;14)down-regulatesTP53repressesR-3620.002248617Pr-5
RNASeq_FGFR3_Calldown-regulatesTP53repressesR-3620.002248617Pr-5
t(4;14)down-regulatesTP53repressesR-3620.002248617Pr-5
SYNE1up-regulatesTP53repressesR-3620.002248617Pr-5
del13down-regulatesTP53repressesR-3620.002248617Pr-5
t(4;14)_cytogeneticdown-regulatesTP53repressesR-3620.002248617Pr-5
FAM46Cdown-regulatesZFXactivatesR-19240.006749428Pr-5
t(11;14)up-regulatesZFXactivatesR-19240.006749428Pr-5
t(14;16)up-regulatesZFXactivatesR-19240.006749428Pr-5
WDFY3up-regulatesZFXactivatesR-19240.006749428Pr-5
amp1qup-regulatesZFXactivatesR-19240.006749428Pr-5
del13up-regulatesZFXactivatesR-19240.006749428Pr-5
AHNAK2up-regulatesARID3ArepressesR-13370.13425321Pr-5
t(11;14)down-regulatesARID3ArepressesR-13370.13425321Pr-5
AHNAK2down-regulatesATF4activatesR-920.1793359Pr-5
CMYA5down-regulatesATF4activatesR-920.1793359Pr-5
DIS3up-regulatesATF4activatesR-920.1793359Pr-5
t(11;14)up-regulatesATF4activatesR-920.1793359Pr-5
RNASeq_FGFR3_Callup-regulatesATF4activatesR-920.1793359Pr-5
t(14;16)up-regulatesATF4activatesR-920.1793359Pr-5
t(4;14)up-regulatesATF4activatesR-920.1793359Pr-5
SYNE1down-regulatesATF4activatesR-920.1793359Pr-5
amp1qup-regulatesATF4activatesR-920.1793359Pr-5
del13up-regulatesATF4activatesR-920.1793359Pr-5
t(11;14)_cytogeneticup-regulatesATF4activatesR-920.1793359Pr-5
t(4;14)_cytogeneticup-regulatesATF4activatesR-920.1793359Pr-5
AHNAK2down-regulatesFOXK1activatesR-1207-0.2377769Pr-5
FAT3down-regulatesFOXK1activatesR-1207-0.2377769Pr-5
KALRNdown-regulatesFOXK1activatesR-1207-0.2377769Pr-5
MACF1down-regulatesFOXK1activatesR-1207-0.2377769Pr-5
MAGI1down-regulatesFOXK1activatesR-1207-0.2377769Pr-5
MYO10down-regulatesFOXK1activatesR-1207-0.2377769Pr-5
NEBdown-regulatesFOXK1activatesR-1207-0.2377769Pr-5
PTPRDdown-regulatesFOXK1activatesR-1207-0.2377769Pr-5
t(4;14)up-regulatesFOXK1activatesR-1207-0.2377769Pr-5
TACC2down-regulatesFOXK1activatesR-1207-0.2377769Pr-5
amp1qup-regulatesFOXK1activatesR-1207-0.2377769Pr-5
del13up-regulatesFOXK1activatesR-1207-0.2377769Pr-5
AHNAK2down-regulatesFOXP1activatesR-31370.24240913Pr-5
PCDH7down-regulatesFOXP1activatesR-31370.24240913Pr-5
TACC2down-regulatesFOXP1activatesR-31370.24240913Pr-5
amp1qup-regulatesFOXP1activatesR-31370.24240913Pr-5
del13up-regulatesFOXP1activatesR-31370.24240913Pr-5
CMYA5down-regulatesYY1activatesR-25270.2517748Pr-5
DIS3up-regulatesYY1activatesR-25270.2517748Pr-5
DSTdown-regulatesYY1activatesR-25270.2517748Pr-5
FGFR3up-regulatesYY1activatesR-25270.2517748Pr-5
PRDM1up-regulatesYY1activatesR-25270.2517748Pr-5
RNASeq_FGFR3_Callup-regulatesYY1activatesR-25270.2517748Pr-5
t(4;14)up-regulatesYY1activatesR-25270.2517748Pr-5
TRAF3down-regulatesYY1activatesR-25270.2517748Pr-5
del13up-regulatesYY1activatesR-25270.2517748Pr-5
t(4;14)_cytogeneticup-regulatesYY1activatesR-25270.2517748Pr-5
ABCA13down-regulatesFOXO3activatesR-2775-0.2804410Pr-5
PKHD1L1down-regulatesFOXO3activatesR-2775-0.2804410Pr-5
t(11;14)up-regulatesEWSR1activatesR-25620.3256256Pr-5
amp1qup-regulatesEWSR1activatesR-25620.3256256Pr-5
t(11;14)_cytogeneticup-regulatesEWSR1activatesR-25620.3256256Pr-5
AHNAK2down-regulatesZFXactivatesR-1927-0.367427Pr-5
t(11;14)up-regulatesZFXactivatesR-1927-0.367427Pr-5
t(14;16)up-regulatesZFXactivatesR-1927-0.367427Pr-5
MYCdown-regulatesZFXactivatesR-1927-0.367427Pr-5
t(4;14)up-regulatesZFXactivatesR-1927-0.367427Pr-5
TP53down-regulatesZFXactivatesR-1927-0.367427Pr-5
amp1qup-regulatesZFXactivatesR-1927-0.367427Pr-5
del13up-regulatesZFXactivatesR-1927-0.367427Pr-5
RNASeq_MAFA_Calldown-regulatesRFX7activatesR-27490.4730787Pr-5
BAI3down-regulatesPBX1activatesR-2109-0.83354514Pr-5
DIS3up-regulatesPBX1activatesR-2109-0.83354514Pr-5
FGFR3up-regulatesPBX1activatesR-2109-0.83354514Pr-5
KDM3Bdown-regulatesPBX1activatesR-2109-0.83354514Pr-5
KMT2Bdown-regulatesPBX1activatesR-2109-0.83354514Pr-5
LTBup-regulatesPBX1activatesR-2109-0.83354514Pr-5
PRKD2up-regulatesPBX1activatesR-2109-0.83354514Pr-5
RNASeq_FGFR3_Callup-regulatesPBX1activatesR-2109-0.83354514Pr-5
t(4;14)up-regulatesPBX1activatesR-2109-0.83354514Pr-5
amp1qup-regulatesPBX1activatesR-2109-0.83354514Pr-5
del13up-regulatesPBX1activatesR-2109-0.83354514Pr-5
t(4;14)_cytogeneticup-regulatesPBX1activatesR-2109-0.83354514Pr-5
AHNAK2down-regulatesFOXK1activatesR-1198-0.84886313Pr-5
FAT3down-regulatesFOXK1activatesR-1198-0.84886313Pr-5
TACC2down-regulatesFOXK1activatesR-1198-0.84886313Pr-5
amp1qup-regulatesFOXK1activatesR-1198-0.84886313Pr-5
del13up-regulatesFOXK1activatesR-1198-0.84886313Pr-5
t(4;14)up-regulatesUSF1activatesR-18540.85606813Pr-5
del13up-regulatesUSF1activatesR-18540.85606813Pr-5
t(11;14)_cytogeneticup-regulatesUSF1activatesR-18540.85606813Pr-5
AHNAK2down-regulatesCREB1activatesR-2751.024247Pr-5
amp1qup-regulatesCREB1activatesR-2751.024247Pr-5
del13up-regulatesCREB1activatesR-2751.024247Pr-5
CMYA5down-regulatesFOXJ3activatesR-28831.0515227Pr-5
PTPRDdown-regulatesFOXJ3activatesR-28831.0515227Pr-5
RNASeq_FGFR3_Callup-regulatesFOXJ3activatesR-28831.0515227Pr-5
RNASeq_MAFA_Calldown-regulatesFOXJ3activatesR-28831.0515227Pr-5
t(4;14)up-regulatesFOXJ3activatesR-28831.0515227Pr-5
SYNE1down-regulatesFOXJ3activatesR-28831.0515227Pr-5
del13up-regulatesFOXJ3activatesR-28831.0515227Pr-5
del17pdown-regulatesFOXJ3activatesR-28831.0515227Pr-5
DIS3down-regulatesMZF1repressesR-30161.1532615Pr-5
FGFR3down-regulatesMZF1repressesR-30161.1532615Pr-5
IRF4down-regulatesMZF1repressesR-30161.1532615Pr-5
LTBdown-regulatesMZF1repressesR-30161.1532615Pr-5
t(11;14)down-regulatesMZF1repressesR-30161.1532615Pr-5
RNASeq_FGFR3_Calldown-regulatesMZF1repressesR-30161.1532615Pr-5
t(14;16)down-regulatesMZF1repressesR-30161.1532615Pr-5
t(4;14)down-regulatesMZF1repressesR-30161.1532615Pr-5
amp1qdown-regulatesMZF1repressesR-30161.1532615Pr-5
del13down-regulatesMZF1repressesR-30161.1532615Pr-5
t(11;14)_cytogeneticdown-regulatesMZF1repressesR-30161.1532615Pr-5
t(4;14)_cytogeneticdown-regulatesMZF1repressesR-30161.1532615Pr-5
t(14;16)up-regulatesKLF7activatesR-286-1.25717Pr-5
amp1qup-regulatesKLF7activatesR-286-1.25717Pr-5
del13up-regulatesKLF7activatesR-286-1.25717Pr-5
AHNAK2up-regulatesARID3ArepressesR-1350-1.273458Pr-5
t(11;14)down-regulatesARID3ArepressesR-1350-1.273458Pr-5
DIS3up-regulatesARNTactivatesR-20381.285948Pr-5
DMDup-regulatesARNTactivatesR-20381.285948Pr-5
t(14;16)up-regulatesARNTactivatesR-20381.285948Pr-5
t(4;14)up-regulatesARNTactivatesR-20381.285948Pr-5
amp1qup-regulatesARNTactivatesR-20381.285948Pr-5
del13up-regulatesARNTactivatesR-20381.285948Pr-5
AHNAK2down-regulatesRARAactivatesR-1481.362231Pr-5
CMYA5down-regulatesRARAactivatesR-1481.362231Pr-5
DNAH5down-regulatesRARAactivatesR-1481.362231Pr-5
IRF4up-regulatesRARAactivatesR-1481.362231Pr-5
MACF1down-regulatesRARAactivatesR-1481.362231Pr-5
NEBdown-regulatesRARAactivatesR-1481.362231Pr-5
t(11;14)up-regulatesRARAactivatesR-1481.362231Pr-5
TACC2down-regulatesRARAactivatesR-1481.362231Pr-5
del13up-regulatesRARAactivatesR-1481.362231Pr-5
del17down-regulatesRARAactivatesR-1481.362231Pr-5
del17pdown-regulatesRARAactivatesR-1481.362231Pr-5
t(11;14)_cytogeneticup-regulatesRARAactivatesR-1481.362231Pr-5
BRAFup-regulatesDR1activatesR-421.3862411Pr-5
DMDup-regulatesDR1activatesR-421.3862411Pr-5
t(11;14)up-regulatesDR1activatesR-421.3862411Pr-5
t(14;16)up-regulatesDR1activatesR-421.3862411Pr-5
amp1qup-regulatesDR1activatesR-421.3862411Pr-5
del13up-regulatesDR1activatesR-421.3862411Pr-5
t(11;14)_cytogeneticup-regulatesDR1activatesR-421.3862411Pr-5
AHNAK2up-regulatesMLXrepressesR-31981.413698Pr-5
ANK2up-regulatesMLXrepressesR-31981.413698Pr-5
CMYA5up-regulatesMLXrepressesR-31981.413698Pr-5
t(11;14)down-regulatesMLXrepressesR-31981.413698Pr-5
SYNE1up-regulatesMLXrepressesR-31981.413698Pr-5
TACC2up-regulatesMLXrepressesR-31981.413698Pr-5
del17pup-regulatesMLXrepressesR-31981.413698Pr-5
t(11;14)_cytogeneticdown-regulatesMLXrepressesR-31981.413698Pr-5
AHNAK2down-regulatesRFX1activatesR-2569-1.470327Pr-5
t(11;14)up-regulatesRFX1activatesR-2569-1.470327Pr-5
amp1qup-regulatesRFX1activatesR-2569-1.470327Pr-5
del13up-regulatesRFX1activatesR-2569-1.470327Pr-5
AHNAK2down-regulatesRREB1activatesR-22821.6085229Pr-5
TACC2down-regulatesRREB1activatesR-22821.6085229Pr-5
CMYA5down-regulatesZBTB16activatesR-581-1.6490916Pr-5
DIS3up-regulatesZBTB16activatesR-581-1.6490916Pr-5
DNAH5down-regulatesZBTB16activatesR-581-1.6490916Pr-5
FGFR3up-regulatesZBTB16activatesR-581-1.6490916Pr-5
PRKD2up-regulatesZBTB16activatesR-581-1.6490916Pr-5
t(11;14)up-regulatesZBTB16activatesR-581-1.6490916Pr-5
RNASeq_FGFR3_Callup-regulatesZBTB16activatesR-581-1.6490916Pr-5
t(4;14)up-regulatesZBTB16activatesR-581-1.6490916Pr-5
t(11;14)_cytogeneticup-regulatesZBTB16activatesR-581-1.6490916Pr-5
t(4;14)_cytogeneticup-regulatesZBTB16activatesR-581-1.6490916Pr-5
CMYA5down-regulatesZBTB16activatesR-590-1.673998Pr-5
t(11;14)up-regulatesZBTB16activatesR-590-1.673998Pr-5
TRAF3down-regulatesZBTB16activatesR-590-1.673998Pr-5
AHNAK2down-regulatesELF4activatesR-2346-1.6745614Pr-5
t(11;14)up-regulatesELF4activatesR-2346-1.6745614Pr-5
t(14;16)up-regulatesELF4activatesR-2346-1.6745614Pr-5
AHNAK2down-regulatesRORAactivatesR-22651.6767922Pr-5
ASXL3down-regulatesRORAactivatesR-22651.6767922Pr-5
BRAFup-regulatesRORAactivatesR-22651.6767922Pr-5
amp1qup-regulatesRORAactivatesR-22651.6767922Pr-5
del13up-regulatesRORAactivatesR-22651.6767922Pr-5
DMDup-regulatesZNF281activatesR-24731.7792347Pr-5
NEBdown-regulatesZNF281activatesR-24731.7792347Pr-5
t(11;14)up-regulatesZNF281activatesR-24731.7792347Pr-5
RNASeq_FGFR3_Callup-regulatesZNF281activatesR-24731.7792347Pr-5
t(4;14)up-regulatesZNF281activatesR-24731.7792347Pr-5
TACC2down-regulatesZNF281activatesR-24731.7792347Pr-5
amp1qup-regulatesZNF281activatesR-24731.7792347Pr-5
del13up-regulatesZNF281activatesR-24731.7792347Pr-5
t(11;14)_cytogeneticup-regulatesZNF281activatesR-24731.7792347Pr-5
DMDup-regulatesHMBOX1activatesR-23771.8279612Pr-5
FGFR3up-regulatesHMBOX1activatesR-23771.8279612Pr-5
PCDH10down-regulatesHMBOX1activatesR-23771.8279612Pr-5
PKHD1up-regulatesHMBOX1activatesR-23771.8279612Pr-5
t(11;14)up-regulatesHMBOX1activatesR-23771.8279612Pr-5
t(11;14)_cytogeneticup-regulatesHMBOX1activatesR-23771.8279612Pr-5
SDK1down-regulatesPBX1activatesR-2110-1.86969Pr-5
amp1qup-regulatesPBX1activatesR-2110-1.86969Pr-5
del13up-regulatesPBX1activatesR-2110-1.86969Pr-5
CMYA5down-regulatesE2F7activatesR-13853.103646Pr-5
NRASup-regulatesE2F7activatesR-13853.103646Pr-5
t(11;14)up-regulatesE2F7activatesR-13853.103646Pr-5
t(11;14)_cytogeneticup-regulatesE2F7activatesR-13853.103646Pr-5

Regulons in program Pr-5

Regulon Cox Hazard Ratio # genes # causal flows
R-3620.0022486179
R-19240.0067494286
R-13370.134253212
R-920.179335912
R-1207-0.237776912
R-31370.242409135
R-25270.251774810
R-2775-0.28044102
R-25620.32562563
R-1927-0.3674278
R-27490.47307871
R-2109-0.8335451412
R-1198-0.848863135
R-18540.856068133
R-2751.0242473
R-28831.05152278
R-30161.153261512
R-286-1.257173
R-1350-1.2734582
R-20381.2859486
R-1481.36223112
R-421.38624117
R-31981.4136988
R-2569-1.4703274
R-22821.60852292
R-581-1.649091610
R-590-1.6739983
R-2346-1.67456143
R-22651.67679225
R-24731.77923479
R-23771.82796126
R-2110-1.869693
R-13853.1036464

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions