Program

Causal Mechanistic Flows with regulons in program Pr-40

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
FAT3down-regulatesMAFKrepressesR-28010.28354820Pr-40
MAGI1down-regulatesMAFKrepressesR-28010.28354820Pr-40
RNASeq_MAFA_Calldown-regulatesMAFKrepressesR-28010.28354820Pr-40
TACC2down-regulatesMAFKrepressesR-28010.28354820Pr-40
t(11;14)down-regulatesIRF4activatesR-490-0.58054413Pr-40
t(11;14)_cytogeneticdown-regulatesIRF4activatesR-490-0.58054413Pr-40
AHNAK2down-regulatesIRF7activatesR-1084-0.86152616Pr-40
DSTdown-regulatesIRF7activatesR-1084-0.86152616Pr-40
FLGdown-regulatesIRF7activatesR-1084-0.86152616Pr-40
NFKB2up-regulatesIRF7activatesR-1084-0.86152616Pr-40
ROBO1down-regulatesIRF7activatesR-1084-0.86152616Pr-40
SVEP1down-regulatesIRF7activatesR-1084-0.86152616Pr-40
TP53up-regulatesIRF7activatesR-1084-0.86152616Pr-40
TRAF3down-regulatesIRF7activatesR-1084-0.86152616Pr-40
AHNAK2down-regulatesIRF7activatesR-1092-0.9760539Pr-40
DSTdown-regulatesIRF7activatesR-1092-0.9760539Pr-40
FLGdown-regulatesIRF7activatesR-1092-0.9760539Pr-40
LTBdown-regulatesIRF7activatesR-1092-0.9760539Pr-40
NFKB2up-regulatesIRF7activatesR-1092-0.9760539Pr-40
NRASup-regulatesIRF7activatesR-1092-0.9760539Pr-40
t(4;14)down-regulatesIRF7activatesR-1092-0.9760539Pr-40
ROBO1down-regulatesIRF7activatesR-1092-0.9760539Pr-40
SVEP1down-regulatesIRF7activatesR-1092-0.9760539Pr-40
TP53up-regulatesIRF7activatesR-1092-0.9760539Pr-40
TRAF3down-regulatesIRF7activatesR-1092-0.9760539Pr-40
amp1qdown-regulatesIRF7activatesR-1092-0.9760539Pr-40
del13down-regulatesIRF7activatesR-1092-0.9760539Pr-40
t(4;14)_cytogeneticdown-regulatesIRF7activatesR-1092-0.9760539Pr-40
AHNAK2down-regulatesIRF9activatesR-1152-1.0123517Pr-40
DIS3up-regulatesIRF9activatesR-1152-1.0123517Pr-40
DSTdown-regulatesIRF9activatesR-1152-1.0123517Pr-40
FLGdown-regulatesIRF9activatesR-1152-1.0123517Pr-40
MYH2up-regulatesIRF9activatesR-1152-1.0123517Pr-40
RNASeq_FGFR3_Callup-regulatesIRF9activatesR-1152-1.0123517Pr-40
ROBO1down-regulatesIRF9activatesR-1152-1.0123517Pr-40
SVEP1down-regulatesIRF9activatesR-1152-1.0123517Pr-40
SYNE2up-regulatesIRF9activatesR-1152-1.0123517Pr-40
TP53up-regulatesIRF9activatesR-1152-1.0123517Pr-40
TRAF3down-regulatesIRF9activatesR-1152-1.0123517Pr-40
del17up-regulatesIRF9activatesR-1152-1.0123517Pr-40
NFKB2up-regulatesIRF4activatesR-494-1.02176Pr-40
t(4;14)down-regulatesIRF4activatesR-494-1.02176Pr-40
amp1qdown-regulatesIRF4activatesR-494-1.02176Pr-40
del13down-regulatesIRF4activatesR-494-1.02176Pr-40
t(4;14)_cytogeneticdown-regulatesIRF4activatesR-494-1.02176Pr-40
AHNAK2down-regulatesIRF7activatesR-1090-1.046911Pr-40
DSTdown-regulatesIRF7activatesR-1090-1.046911Pr-40
FLGdown-regulatesIRF7activatesR-1090-1.046911Pr-40
LTBdown-regulatesIRF7activatesR-1090-1.046911Pr-40
NFKB2up-regulatesIRF7activatesR-1090-1.046911Pr-40
RNASeq_FGFR3_Calldown-regulatesIRF7activatesR-1090-1.046911Pr-40
t(4;14)down-regulatesIRF7activatesR-1090-1.046911Pr-40
ROBO1down-regulatesIRF7activatesR-1090-1.046911Pr-40
SVEP1down-regulatesIRF7activatesR-1090-1.046911Pr-40
TP53up-regulatesIRF7activatesR-1090-1.046911Pr-40
TRAF3down-regulatesIRF7activatesR-1090-1.046911Pr-40
amp1qdown-regulatesIRF7activatesR-1090-1.046911Pr-40
t(4;14)_cytogeneticdown-regulatesIRF7activatesR-1090-1.046911Pr-40
AHNAK2down-regulatesIRF1activatesR-192-1.0672619Pr-40
DSTdown-regulatesIRF1activatesR-192-1.0672619Pr-40
FGFR3up-regulatesIRF1activatesR-192-1.0672619Pr-40
PRDM1up-regulatesIRF1activatesR-192-1.0672619Pr-40
RNASeq_FGFR3_Callup-regulatesIRF1activatesR-192-1.0672619Pr-40
TP53up-regulatesIRF1activatesR-192-1.0672619Pr-40
TRAF3down-regulatesIRF1activatesR-192-1.0672619Pr-40
AHNAK2down-regulatesIRF9activatesR-1154-1.1002510Pr-40
DSTdown-regulatesIRF9activatesR-1154-1.1002510Pr-40
FLGdown-regulatesIRF9activatesR-1154-1.1002510Pr-40
NFKB2up-regulatesIRF9activatesR-1154-1.1002510Pr-40
SVEP1down-regulatesIRF9activatesR-1154-1.1002510Pr-40
TP53up-regulatesIRF9activatesR-1154-1.1002510Pr-40
TRAF3down-regulatesIRF9activatesR-1154-1.1002510Pr-40

Regulons in program Pr-40

Regulon Cox Hazard Ratio # genes # causal flows
R-28010.283548204
R-490-0.580544132
R-1084-0.861526168
R-1092-0.976053914
R-1152-1.012351712
R-494-1.021765
R-1090-1.04691113
R-192-1.06726197
R-1154-1.10025107

Genes in program Pr-40

EnsEMBL IdEntrez IdPreferred
ENSG00000178105 1662DDX10
ENSG00000182512 51218GLRX5
ENSG00000186265 151888BTLA
ENSG00000187778 10445MCRS1
ENSG00000188389 5133PDCD1
ENSG00000188486 3014H2AFX
ENSG00000188878 85302FBF1
ENSG00000189060 3005H1F0
ENSG00000196208 9687GREB1

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions