Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation TACC2

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
ELF3down-regulatesR-21360.0676162Pr-1
TRAF4down-regulatesR-3037-0.0698997Pr-2
STAT3down-regulatesR-311-0.0731142Pr-135
ELF3down-regulatesR-21480.0747421Pr-3
MEF2Adown-regulatesR-18760.111678Pr-137
FOXJ3down-regulatesR-28790.135462Pr-4
TCF7L1down-regulatesR-3174-0.135953Pr-99
MEF2Adown-regulatesR-18840.142343Pr-23
VBP1up-regulatesR-2104-0.154186Pr-2
HBP1down-regulatesR-1826-0.154819Pr-1
ARID5Adown-regulatesR-610-0.170127Pr-135
FOXO1down-regulatesR-13950.17036Pr-1
ZEB1down-regulatesR-22520.171985Pr-117
CEBPGdown-regulatesR-453-0.180512Pr-99
ZNF410down-regulatesR-1940-0.201053Pr-133
NFIL3down-regulatesR-16850.22459Pr-1
GMEB2down-regulatesR-2156-0.237482Pr-0
FOXK1down-regulatesR-1207-0.237776Pr-5
FOXP1down-regulatesR-31370.242409Pr-5
CEBPGdown-regulatesR-436-0.258645Pr-2
ZBTB3up-regulatesR-1266-0.259836Pr-117
POU2F1down-regulatesR-78-0.272418Pr-2
FOXJ3down-regulatesR-28820.27442Pr-117
HBP1down-regulatesR-18320.278908Pr-14
MAFKdown-regulatesR-28010.283548Pr-40
FOXJ3down-regulatesR-2876-0.290335Pr-3
FOXK1down-regulatesR-1191-0.320198Pr-3
FOXJ3down-regulatesR-28720.323358Pr-1
ZNF281down-regulatesR-24900.3247Pr-3
ZNF281down-regulatesR-2479-0.333368Pr-2
HSF1down-regulatesR-49-0.350252Pr-2
FOXK1down-regulatesR-1192-0.353736Pr-0
HBP1down-regulatesR-18390.37241Pr-23
CEBPGdown-regulatesR-4510.388628Pr-117
MEF2Adown-regulatesR-1869-0.397022Pr-2
HBP1down-regulatesR-1831-0.397545Pr-2
ARID5Adown-regulatesR-596-0.400576Pr-1
MLXup-regulatesR-3197-0.407624Pr-0
FOXP1down-regulatesR-3121-0.417258Pr-3
ZBTB3up-regulatesR-1275-0.421961Pr-3
FOXK1down-regulatesR-11900.433468Pr-1
NFKB1down-regulatesR-1572-0.445091Pr-0
FOXK1down-regulatesR-1212-0.459405Pr-99
FOXP1down-regulatesR-3120-0.467693Pr-6
ELK1down-regulatesR-6360.485452Pr-0
CEBPGdown-regulatesR-435-0.497945Pr-6
FOXO1down-regulatesR-14060.499782Pr-18
MEF2Adown-regulatesR-1866-0.518528Pr-3
EWSR1down-regulatesR-2541-0.524632Pr-0
CEBPGdown-regulatesR-440-0.532761Pr-0
RREB1down-regulatesR-2285-0.538758Pr-3
NFKB1down-regulatesR-1574-0.538784Pr-2
FOXO1down-regulatesR-1417-0.539502Pr-3
ENSG00000168269down-regulatesR-1561-0.547918Pr-2
FOXP1down-regulatesR-3126-0.555658Pr-2
POU2F1down-regulatesR-690.559914Pr-1
ZBTB3up-regulatesR-1272-0.568661Pr-85
ZNF281down-regulatesR-24740.571768Pr-1
NFKB1down-regulatesR-1591-0.58346Pr-117
NR4A2down-regulatesR-1717-0.584893Pr-2
POU2F1down-regulatesR-71-0.58757Pr-3
HSF1down-regulatesR-50-0.599033Pr-16
ZBTB3up-regulatesR-12700.603274Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

FOXJ2down-regulatesR-14190.60607Pr-1
MEF2Adown-regulatesR-1865-0.617403Pr-6
RREB1down-regulatesR-2283-0.618728Pr-2
CEBPGdown-regulatesR-4340.620526Pr-1
RREB1down-regulatesR-2300-0.646333Pr-20
HIC2down-regulatesR-23710.647812Pr-117
ELF3down-regulatesR-2141-0.655011Pr-39
ZNF281down-regulatesR-2472-0.661858Pr-0
FOXO1down-regulatesR-1396-0.668881Pr-6
FOXJ3down-regulatesR-28890.679009Pr-23
FOXJ2down-regulatesR-1420-0.718874Pr-6
RREB1down-regulatesR-2296-0.757232Pr-9
FOXJ2down-regulatesR-14310.765091Pr-16
ELK1down-regulatesR-6480.765153Pr-99
RARBup-regulatesR-1107-0.777096Pr-9
TRAF4down-regulatesR-3033-0.781484Pr-0
CEBPGdown-regulatesR-443-0.789852Pr-4
POU2F1down-regulatesR-890.796686Pr-18
HSF1down-regulatesR-51-0.803656Pr-19
FOXO1down-regulatesR-1394-0.807027Pr-0
FOXK1down-regulatesR-1188-0.824193Pr-0
FOXK1down-regulatesR-1198-0.848863Pr-5
ELF3down-regulatesR-2135-0.853767Pr-0
RARAdown-regulatesR-159-0.860941Pr-9
EWSR1down-regulatesR-25420.861688Pr-1
FOXJ3down-regulatesR-2874-0.864638Pr-6
FOXJ3down-regulatesR-2873-0.871109Pr-2
CDC5Ldown-regulatesR-16300.87323Pr-1
HSF1down-regulatesR-52-0.875962Pr-9
STAT3down-regulatesR-3090.879665Pr-23
ZBTB3up-regulatesR-1264-0.885093Pr-9
POU2F1down-regulatesR-70-0.911223Pr-6
ERFdown-regulatesR-3370.913173Pr-135
ETV3down-regulatesR-25310.919835Pr-136
ZEB1down-regulatesR-22380.929885Pr-136
FOXP1down-regulatesR-3119-0.932927Pr-0
STAT3down-regulatesR-301-0.935216Pr-0
GABPB1down-regulatesR-1953-0.958675Pr-9
GABPB1down-regulatesR-19490.960779Pr-13
ERFdown-regulatesR-3310.969151Pr-136
ZSCAN16up-regulatesR-630-0.981764Pr-117
ENSG00000168269down-regulatesR-1560-0.982515Pr-0
FOXJ3down-regulatesR-2870-0.999227Pr-0
POU2F1down-regulatesR-66-1.00411Pr-0
NR4A2down-regulatesR-1718-1.0054Pr-9
GABPAup-regulatesR-1454-1.00665Pr-135
ELK1down-regulatesR-6391.02155Pr-13
ARID5Adown-regulatesR-595-1.02768Pr-0
FOXO1down-regulatesR-1398-1.0377Pr-14
MAFKdown-regulatesR-28001.04701Pr-13
NFKB1down-regulatesR-1585-1.04936Pr-4
CEBPGdown-regulatesR-433-1.08132Pr-0
MEF2Adown-regulatesR-18641.08745Pr-1
RREB1down-regulatesR-2298-1.11227Pr-6
FOXJ3down-regulatesR-28841.12637Pr-16
MAFKdown-regulatesR-2798-1.12983Pr-0
FOXJ2down-regulatesR-1418-1.1481Pr-0
ARID5Adown-regulatesR-599-1.1493Pr-2
FOXK1down-regulatesR-1189-1.15299Pr-2
POU2F1down-regulatesR-841.16934Pr-16
ELF2down-regulatesR-9791.18484Pr-135
BACH1down-regulatesR-4731.2099Pr-13
ERFdown-regulatesR-333-1.22378Pr-3
RREB1down-regulatesR-22901.22484Pr-16
ETV3down-regulatesR-2536-1.23178Pr-135
EWSR1down-regulatesR-2561-1.24127Pr-6
MEF2Adown-regulatesR-1878-1.24921Pr-9
ZNF281down-regulatesR-2488-1.25749Pr-0
MAFKdown-regulatesR-2806-1.27994Pr-9
ENSG00000168269down-regulatesR-15641.28019Pr-59
STAT3down-regulatesR-3021.28285Pr-1
FOXP1down-regulatesR-31281.29587Pr-16
ELK1down-regulatesR-654-1.31124Pr-59
GABPAup-regulatesR-14551.3231Pr-135
ZNF281down-regulatesR-2486-1.32496Pr-2
EWSR1down-regulatesR-25461.34254Pr-13
MEF2Adown-regulatesR-18711.35384Pr-16
RARAdown-regulatesR-1481.3622Pr-5
CEBPGdown-regulatesR-448-1.37561Pr-10
NFKB1down-regulatesR-1583-1.38564Pr-9
ELF3down-regulatesR-2143-1.40118Pr-9
E2F2up-regulatesR-29491.40408Pr-16
ZNF281down-regulatesR-2480-1.41308Pr-9
MLXup-regulatesR-31981.41369Pr-5
FOXO1down-regulatesR-1408-1.42694Pr-9
ELF3down-regulatesR-2153-1.43759Pr-0
EWSR1down-regulatesR-2553-1.45023Pr-0
FOXJ3down-regulatesR-2892-1.46097Pr-10
FOXK1down-regulatesR-1205-1.46171Pr-10
GABPAup-regulatesR-14521.4809Pr-136
HSF2down-regulatesR-3166-1.48665Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

GABPB1down-regulatesR-1956-1.51438Pr-135
RREB1down-regulatesR-2305-1.52832Pr-0
CEBPGdown-regulatesR-442-1.55989Pr-9
ZNF281down-regulatesR-2483-1.56826Pr-19
CEBPZup-regulatesR-757-1.57918Pr-10
RARAdown-regulatesR-1651.59669Pr-18
RREB1down-regulatesR-22821.60852Pr-5
ETV3down-regulatesR-25341.64074Pr-13
EWSR1down-regulatesR-2551-1.6617Pr-19
ELF3down-regulatesR-2149-1.67654Pr-10
ZNF281down-regulatesR-2491-1.68427Pr-10
ZEB1down-regulatesR-22491.69836Pr-1
FOXJ2down-regulatesR-14211.70246Pr-136
ELK1down-regulatesR-651-1.70669Pr-6
ZBTB4down-regulatesR-20901.72041Pr-117
HBP1down-regulatesR-18271.73978Pr-136
ZNF281down-regulatesR-24731.77923Pr-5
FOXK1down-regulatesR-1202-1.92921Pr-28
RREB1down-regulatesR-2302-1.95334Pr-10
HBP1down-regulatesR-18441.97565Pr-73
ELK1down-regulatesR-6502.0246Pr-99
MAFKdown-regulatesR-28082.02924Pr-1
ARID5Adown-regulatesR-602-2.062Pr-28
EP300down-regulatesR-2432-2.06462Pr-4
FOXJ2down-regulatesR-14332.07986Pr-8
ETV3down-regulatesR-2532-2.0819Pr-3
VBP1up-regulatesR-2099-2.16715Pr-4
TRAF4down-regulatesR-3035-2.1684Pr-17
RELdown-regulatesR-12792.17366Pr-16
SRFdown-regulatesR-1778-2.26549Pr-4
CDC5Ldown-regulatesR-1633-2.28378Pr-4
RELdown-regulatesR-1277-2.29016Pr-4
RELAdown-regulatesR-1463-2.30399Pr-4
RREB1down-regulatesR-2286-2.31249Pr-17
NFKB1down-regulatesR-1573-2.35352Pr-4
RARAdown-regulatesR-167-2.36681Pr-3
MAFKdown-regulatesR-2804-2.38089Pr-11
FOXO1down-regulatesR-1399-2.38797Pr-17
HBP1down-regulatesR-1845-2.40009Pr-6
MAFKdown-regulatesR-2799-2.41258Pr-4
POU2F1down-regulatesR-68-2.42589Pr-4
ENSG00000168269down-regulatesR-15712.51736Pr-136
FOXP1down-regulatesR-3132-2.58418Pr-11
FOXO1down-regulatesR-1416-2.62977Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ZNF281down-regulatesR-2487-2.70466Pr-4
TCF7L1down-regulatesR-3173-2.7488Pr-11
HBP1down-regulatesR-1829-2.78136Pr-17
NFIL3down-regulatesR-1684-2.82079Pr-4
CEBPGdown-regulatesR-446-2.9189Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

FOXJ2down-regulatesR-1439-2.93208Pr-11
ETV3down-regulatesR-25302.93772Pr-72
FOXO1down-regulatesR-1405-3.01812Pr-11
MAFKdown-regulatesR-2813-3.12874Pr-4
ARID5Adown-regulatesR-603-3.17009Pr-11
RARAdown-regulatesR-153-3.1944Pr-61
NFKB1down-regulatesR-1589-3.21935Pr-3
RELAdown-regulatesR-14643.32257Pr-70
ZEB1down-regulatesR-2241-3.39487Pr-11
RELAdown-regulatesR-1465-3.41018Pr-17
RARAdown-regulatesR-166-3.60154Pr-20
STAT3down-regulatesR-307-3.61941Pr-11
GABPB1down-regulatesR-1945-3.71816Pr-35
EWSR1down-regulatesR-25543.72615Pr-50
BACH1down-regulatesR-470-3.77843Pr-17
FOXK1down-regulatesR-1196-3.80774Pr-11
ZNF281down-regulatesR-2484-3.91355Pr-20
SRFdown-regulatesR-17814.13916Pr-70
POU2F1down-regulatesR-884.3225Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

POU2F1down-regulatesR-734.62299Pr-70
HBP1down-regulatesR-18474.92709Pr-70
ELF2down-regulatesR-9754.96438Pr-74
ZNF410down-regulatesR-19318.29917Pr-68
FOXO1down-regulatesR-13938.37511Pr-68
E2F2up-regulatesR-29448.90615Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions