Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation MACF1

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
TRAF4down-regulatesR-3037-0.0698997Pr-2
SREBF1up-regulatesR-11390.101608Pr-7
RREB1down-regulatesR-2304-0.103823Pr-135
ELF2down-regulatesR-9740.122498Pr-25
FLI1down-regulatesR-790-0.135687Pr-137
VBP1up-regulatesR-2104-0.154186Pr-2
ZSCAN16up-regulatesR-631-0.165596Pr-2
E4F1down-regulatesR-3147-0.190868Pr-0
FOXK1down-regulatesR-1207-0.237776Pr-5
NFE2L2up-regulatesR-1911-0.246239Pr-2
PARP1up-regulatesR-26390.255441Pr-4
CEBPGdown-regulatesR-436-0.258645Pr-2
POU2F1down-regulatesR-78-0.272418Pr-2
SF1down-regulatesR-1907-0.317014Pr-3
FOXK1down-regulatesR-1191-0.320198Pr-3
RARAdown-regulatesR-160-0.331894Pr-25
ZNF281down-regulatesR-2479-0.333368Pr-2
ERFdown-regulatesR-3360.343262Pr-35
HSF1down-regulatesR-49-0.350252Pr-2
TRAF4down-regulatesR-3043-0.355413Pr-4
HMBOX1down-regulatesR-23820.378178Pr-62
NF1down-regulatesR-1300.381224Pr-109
CEBPGdown-regulatesR-4510.388628Pr-117
SPIBup-regulatesR-6610.39364Pr-85
MEF2Adown-regulatesR-1869-0.397022Pr-2
HBP1down-regulatesR-1831-0.397545Pr-2
ZNF143up-regulatesR-23120.42534Pr-25
NFKB1down-regulatesR-1572-0.445091Pr-0
HINFPdown-regulatesR-2627-0.48712Pr-88
FOXO1down-regulatesR-14060.499782Pr-18
MEF2Adown-regulatesR-1866-0.518528Pr-3
EWSR1down-regulatesR-2541-0.524632Pr-0
E2F2up-regulatesR-2943-0.530398Pr-58
CEBPGdown-regulatesR-440-0.532761Pr-0
RREB1down-regulatesR-2285-0.538758Pr-3
NFKB1down-regulatesR-1574-0.538784Pr-2
FOXO1down-regulatesR-1417-0.539502Pr-3
HMBOX1down-regulatesR-2379-0.550956Pr-3
IKZF1down-regulatesR-9910.573701Pr-124
ZNF143up-regulatesR-2309-0.580912Pr-2
FOXO1down-regulatesR-14110.58467Pr-60
NR4A2down-regulatesR-1717-0.584893Pr-2
POU2F1down-regulatesR-71-0.58757Pr-3
RREB1down-regulatesR-2283-0.618728Pr-2
RREB1down-regulatesR-2300-0.646333Pr-20
EWSR1down-regulatesR-25590.652492Pr-125
ZNF281down-regulatesR-2472-0.661858Pr-0
NFKB1down-regulatesR-15770.685997Pr-124
HBP1down-regulatesR-1846-0.703016Pr-117
RREB1down-regulatesR-2296-0.757232Pr-9
MYBup-regulatesR-619-0.781425Pr-59
TRAF4down-regulatesR-3033-0.781484Pr-0
CEBPGdown-regulatesR-443-0.789852Pr-4
POU2F1down-regulatesR-890.796686Pr-18
FOXO1down-regulatesR-1394-0.807027Pr-0
MAZup-regulatesR-508-0.810173Pr-0
STAT5Bup-regulatesR-23660.819111Pr-85
FOXK1down-regulatesR-1188-0.824193Pr-0
HSF1down-regulatesR-52-0.875962Pr-9
ERFdown-regulatesR-3370.913173Pr-135
ATF1up-regulatesR-559-0.936734Pr-0
HBP1down-regulatesR-1835-0.944524Pr-34
JUNdown-regulatesR-1184-0.962738Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

SREBF1up-regulatesR-11370.963749Pr-87
ERFdown-regulatesR-3310.969151Pr-136
POU2F1down-regulatesR-66-1.00411Pr-0
NR4A2down-regulatesR-1718-1.0054Pr-9
VDRdown-regulatesR-12281.0371Pr-87
RFX1down-regulatesR-2572-1.03711Pr-10
CEBPGdown-regulatesR-433-1.08132Pr-0
ELK3down-regulatesR-28451.08229Pr-136
ELF2down-regulatesR-964-1.11857Pr-58
HMBOX1down-regulatesR-23851.11927Pr-18
MAFKdown-regulatesR-2798-1.12983Pr-0
POU2F1down-regulatesR-67-1.13734Pr-58
FOXK1down-regulatesR-1189-1.15299Pr-2
ELF2down-regulatesR-9791.18484Pr-135
MAZup-regulatesR-503-1.19474Pr-9
ATF1up-regulatesR-571-1.19606Pr-10
ERFdown-regulatesR-333-1.22378Pr-3
RARAdown-regulatesR-1641.24046Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MEF2Adown-regulatesR-1878-1.24921Pr-9
ZNF281down-regulatesR-2488-1.25749Pr-0
MAFKdown-regulatesR-2806-1.27994Pr-9
GABPAup-regulatesR-14551.3231Pr-135
SPIBup-regulatesR-6641.32468Pr-87
RARAdown-regulatesR-1481.3622Pr-5
CEBPGdown-regulatesR-448-1.37561Pr-10
NFKB1down-regulatesR-1583-1.38564Pr-9
ZNF281down-regulatesR-2480-1.41308Pr-9
FOXO1down-regulatesR-1408-1.42694Pr-9
RFX1down-regulatesR-2570-1.43236Pr-9
FOXK1down-regulatesR-1205-1.46171Pr-10
GABPAup-regulatesR-14521.4809Pr-136
CEBPGdown-regulatesR-442-1.55989Pr-9
ZNF281down-regulatesR-2483-1.56826Pr-19
CEBPZup-regulatesR-757-1.57918Pr-10
ZNF143up-regulatesR-2322-1.59054Pr-3
RARAdown-regulatesR-1651.59669Pr-18
MAFKdown-regulatesR-2802-1.60272Pr-25
MYBup-regulatesR-6171.6152Pr-87
MYBup-regulatesR-6231.65419Pr-96
EWSR1down-regulatesR-2551-1.6617Pr-19
RFX1down-regulatesR-25661.66776Pr-136
SREBF1up-regulatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

ZNF281down-regulatesR-2491-1.68427Pr-10
HBP1down-regulatesR-18271.73978Pr-136
NFKB1down-regulatesR-1588-1.78822Pr-3
ATF1up-regulatesR-560-1.81953Pr-4
MAZup-regulatesR-4951.8487Pr-87
E2F2up-regulatesR-29451.88745Pr-133
RREB1down-regulatesR-2302-1.95334Pr-10
HBP1down-regulatesR-18441.97565Pr-73
IKZF1down-regulatesR-9941.98155Pr-117
VBP1up-regulatesR-2099-2.16715Pr-4
E2F1up-regulatesR-2176-2.17422Pr-61
ELK3down-regulatesR-28472.18224Pr-135
FLI1down-regulatesR-7842.19671Pr-137
IKZF1down-regulatesR-9962.22566Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

SRFdown-regulatesR-1778-2.26549Pr-4
RELAdown-regulatesR-1463-2.30399Pr-4
ELF2down-regulatesR-987-2.34496Pr-20
NFKB1down-regulatesR-1573-2.35352Pr-4
HBP1down-regulatesR-1845-2.40009Pr-6
MAFKdown-regulatesR-2799-2.41258Pr-4
POU2F1down-regulatesR-68-2.42589Pr-4
ERFdown-regulatesR-3352.46806Pr-136
FLI1down-regulatesR-7932.52326Pr-96
IKZF1down-regulatesR-990-2.55623Pr-4
ZNF281down-regulatesR-2487-2.70466Pr-4
MEF2Adown-regulatesR-1887-2.70745Pr-60
HBP1down-regulatesR-18302.71345Pr-73
HINFPdown-regulatesR-2621-2.97505Pr-35
ZBTB7Bup-regulatesR-1232-2.98559Pr-35
ZNF281down-regulatesR-2492-3.05072Pr-85
MEF2Adown-regulatesR-1877-3.20022Pr-38
MAZup-regulatesR-5053.21974Pr-70
SPIBup-regulatesR-6783.32159Pr-87
RELAdown-regulatesR-14643.32257Pr-70
TRIM28down-regulatesR-1506-3.3709Pr-35
MYBup-regulatesR-620-3.37541Pr-38
SPIBup-regulatesR-677-3.40986Pr-41
RELAdown-regulatesR-1465-3.41018Pr-17
BRCA1up-regulatesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

MYBup-regulatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

STAT5Bup-regulatesR-23703.57469Pr-122
NFKB1down-regulatesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

SPIBup-regulatesR-679-3.70577Pr-36
EWSR1down-regulatesR-25543.72615Pr-50
SRFdown-regulatesR-17814.13916Pr-70
E2F8up-regulatesR-16294.14363Pr-136
CEBPGdown-regulatesR-4414.14664Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ERFdown-regulatesR-332-4.16378Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

IKZF1down-regulatesR-9954.16974Pr-74
POU2F1down-regulatesR-884.3225Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MEF2Adown-regulatesR-18804.46094Pr-128
RREB1down-regulatesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

POU2F1down-regulatesR-734.62299Pr-70
POU2F1down-regulatesR-904.80999Pr-128
MEF2Adown-regulatesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

POU2F1down-regulatesR-864.85124Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-506-4.85353Pr-4
HBP1down-regulatesR-18474.92709Pr-70
ELF2down-regulatesR-9754.96438Pr-74
MAZup-regulatesR-4974.96461Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ERFdown-regulatesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

VDRdown-regulatesR-12315.12816Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FLI1down-regulatesR-7836.1459Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ZNF143up-regulatesR-23197.33249Pr-68
PARP1up-regulatesR-26368.12838Pr-68
FOXO1down-regulatesR-13938.37511Pr-68
MYBup-regulatesR-6148.54513Pr-68
E2F2up-regulatesR-29428.59906Pr-68
E2F8up-regulatesR-16268.62493Pr-68
E2F1up-regulatesR-21738.76486Pr-68
E2F1up-regulatesR-21728.82921Pr-68
E2F2up-regulatesR-29448.90615Pr-68
E2F8up-regulatesR-16279.26408Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions