Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation FRAS1

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
BORCS8-MEF2Bup-regulatesR-959-0.721458Pr-58
DBPdown-regulatesR-29530.918338Pr-125
FLI1down-regulatesR-789-1.43137Pr-19
ESRRAdown-regulatesR-27411.72748Pr-125
SRFdown-regulatesR-1788-1.83514Pr-118
PLAG1down-regulatesR-1525-2.09931Pr-42
RUNX2up-regulatesR-12832.3191Pr-123
SRFdown-regulatesR-17862.43898Pr-117
BORCS8-MEF2Bup-regulatesR-9632.55553Pr-82

Genes (2)

ZBED5

Regulons (3)

R-2436, R-2560, R-963

ENSG00000176887up-regulatesR-1898-2.61611Pr-36
BRCA1up-regulatesR-10312.71498Pr-123
ENSG00000105991down-regulatesR-229-2.84707Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

ENSG00000175832up-regulatesR-313-2.85877Pr-101
SRFdown-regulatesR-1779-3.05603Pr-36
ENSG00000175832up-regulatesR-312-3.06Pr-36
FLI1down-regulatesR-780-3.11957Pr-36
ESRRAdown-regulatesR-2745-3.32726Pr-43

Genes (1)

C14orf132

Regulons (3)

R-3072, R-2745, R-608

IRF4down-regulatesR-493-3.47489Pr-35
ENSG00000176887up-regulatesR-1897-3.60963Pr-47

Genes (0)

Regulons (5)

R-591, R-2773, R-1156, R-1897, R-2520

PLAG1down-regulatesR-15273.7556Pr-54
ESRRAdown-regulatesR-2740-4.64571Pr-36
SRFdown-regulatesR-1787-5.29074Pr-104
FLI1down-regulatesR-7836.1459Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

SRFdown-regulatesR-17807.20867Pr-71

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions