Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation FAT3

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
TRAF4down-regulatesR-3037-0.0698997Pr-2
MEF2Adown-regulatesR-18760.111678Pr-137
ELF2down-regulatesR-9740.122498Pr-25
FLI1down-regulatesR-790-0.135687Pr-137
TCF7L1down-regulatesR-3174-0.135953Pr-99
NFIL3down-regulatesR-1686-0.145704Pr-25
ZSCAN16up-regulatesR-631-0.165596Pr-2
CEBPGdown-regulatesR-453-0.180512Pr-99
FOXK1down-regulatesR-1207-0.237776Pr-5
NFE2L2up-regulatesR-1911-0.246239Pr-2
PARP1up-regulatesR-26390.255441Pr-4
CEBPGdown-regulatesR-436-0.258645Pr-2
FOXO1down-regulatesR-14150.265962Pr-33
POU2F1down-regulatesR-78-0.272418Pr-2
ZNF143up-regulatesR-2318-0.27862Pr-4
MAFKdown-regulatesR-28010.283548Pr-40
HSF1down-regulatesR-49-0.350252Pr-2
TRAF4down-regulatesR-3043-0.355413Pr-4
ENSG00000176887up-regulatesR-18930.370377Pr-128
MEF2Adown-regulatesR-1869-0.397022Pr-2
NFKB1down-regulatesR-15860.40155Pr-2
PARP1up-regulatesR-26410.417694Pr-128
NFKB1down-regulatesR-1572-0.445091Pr-0
NFATC2down-regulatesR-1695-0.454371Pr-4
FOXK1down-regulatesR-1212-0.459405Pr-99
BBXdown-regulatesR-1534-0.482476Pr-9
CEBPGdown-regulatesR-440-0.532761Pr-0
ELF3down-regulatesR-21470.536867Pr-33
NFKB1down-regulatesR-1574-0.538784Pr-2
NR4A2down-regulatesR-1717-0.584893Pr-2
NR3C1down-regulatesR-3175-0.602124Pr-0
HSF1down-regulatesR-540.604731Pr-125
VBP1up-regulatesR-21030.638139Pr-135
ELF3down-regulatesR-2141-0.655011Pr-39
ZNF281down-regulatesR-2472-0.661858Pr-0
CREB1down-regulatesR-269-0.734328Pr-0
RREB1down-regulatesR-2296-0.757232Pr-9
ELF3down-regulatesR-2154-0.760352Pr-12
RARBup-regulatesR-1107-0.777096Pr-9
TRAF4down-regulatesR-3033-0.781484Pr-0
CEBPGdown-regulatesR-443-0.789852Pr-4
SP1up-regulatesR-2711-0.793825Pr-0
FOXO1down-regulatesR-1394-0.807027Pr-0
MAZup-regulatesR-508-0.810173Pr-0
ZNF691up-regulatesR-3007-0.816485Pr-2
FOXK1down-regulatesR-1188-0.824193Pr-0
FOXK1down-regulatesR-1198-0.848863Pr-5
ELF3down-regulatesR-2135-0.853767Pr-0
NFATC2down-regulatesR-1687-0.857877Pr-0
ELF2down-regulatesR-985-0.875385Pr-102
HSF1down-regulatesR-52-0.875962Pr-9
ETS1down-regulatesR-4-0.886127Pr-9
ERFdown-regulatesR-3370.913173Pr-135
ETV3down-regulatesR-25310.919835Pr-136
STAT3down-regulatesR-301-0.935216Pr-0
GABPB1down-regulatesR-1953-0.958675Pr-9
ERFdown-regulatesR-3310.969151Pr-136
NFKB1down-regulatesR-1578-0.969867Pr-65
ETS1down-regulatesR-00.98535Pr-136
NFATC1down-regulatesR-2207-1.00385Pr-15
POU2F1down-regulatesR-66-1.00411Pr-0
NR4A2down-regulatesR-1718-1.0054Pr-9
ZNF143up-regulatesR-23141.04902Pr-99
NFKB1down-regulatesR-1585-1.04936Pr-4
CREB1down-regulatesR-273-1.05492Pr-9
NR3C1down-regulatesR-3185-1.06036Pr-0
CEBPGdown-regulatesR-433-1.08132Pr-0
ZNF691up-regulatesR-30111.09639Pr-138
SP1up-regulatesR-2728-1.12023Pr-9
MAFKdown-regulatesR-2798-1.12983Pr-0
CEBPZup-regulatesR-755-1.13966Pr-10
FOXK1down-regulatesR-1189-1.15299Pr-2
NFATC1down-regulatesR-2204-1.15799Pr-10
ELF2down-regulatesR-968-1.17369Pr-86
XBP1up-regulatesR-3050-1.18487Pr-0
MAZup-regulatesR-503-1.19474Pr-9
RREB1down-regulatesR-22901.22484Pr-16
ETV3down-regulatesR-2536-1.23178Pr-135
MEF2Adown-regulatesR-1878-1.24921Pr-9
ZNF281down-regulatesR-2488-1.25749Pr-0
E2F2up-regulatesR-2946-1.27434Pr-15
MAFKdown-regulatesR-2806-1.27994Pr-9
RARBup-regulatesR-11061.29549Pr-108
KLF13down-regulatesR-2041-1.31925Pr-42
ZNF281down-regulatesR-2486-1.32496Pr-2
ZNF143up-regulatesR-2321-1.32991Pr-129
SP1up-regulatesR-27211.33792Pr-111
CEBPGdown-regulatesR-448-1.37561Pr-10
NFKB1down-regulatesR-1583-1.38564Pr-9
FOXO1down-regulatesR-1403-1.38577Pr-12
ELF3down-regulatesR-2143-1.40118Pr-9
E2F2up-regulatesR-29491.40408Pr-16
ZNF281down-regulatesR-2480-1.41308Pr-9
FOXO1down-regulatesR-1408-1.42694Pr-9
FLI1down-regulatesR-789-1.43137Pr-19
ELF3down-regulatesR-2153-1.43759Pr-0
NR3C1down-regulatesR-3193-1.45371Pr-86
FOXK1down-regulatesR-1205-1.46171Pr-10
MZF1down-regulatesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

XBP1up-regulatesR-3064-1.49068Pr-2
CREB1down-regulatesR-277-1.54447Pr-35
CEBPGdown-regulatesR-442-1.55989Pr-9
ZNF281down-regulatesR-2483-1.56826Pr-19
CEBPZup-regulatesR-757-1.57918Pr-10
MAFKdown-regulatesR-2802-1.60272Pr-25
ELF3down-regulatesR-2149-1.67654Pr-10
ZNF281down-regulatesR-2491-1.68427Pr-10
NFATC2down-regulatesR-1697-1.68436Pr-0
NFKB2down-regulatesR-2824-1.72295Pr-4
MAFKdown-regulatesR-2803-1.72936Pr-136
HBP1down-regulatesR-1848-1.73182Pr-15
HBP1down-regulatesR-18271.73978Pr-136
MAZup-regulatesR-511-1.75904Pr-0
MAZup-regulatesR-501-1.77175Pr-19
HSF1down-regulatesR-56-1.77472Pr-36
ZNF143up-regulatesR-2315-1.77492Pr-30
E2F2up-regulatesR-2947-1.79304Pr-102
NFKB1down-regulatesR-1580-1.81925Pr-91
GABPB1down-regulatesR-19461.88107Pr-109
E2F2up-regulatesR-29451.88745Pr-133
CEBPGdown-regulatesR-452-1.91069Pr-86
CREB1down-regulatesR-274-1.97415Pr-10
FOXO1down-regulatesR-1412-1.97656Pr-28
ELF2down-regulatesR-9812.07279Pr-126
POU2F1down-regulatesR-872.07888Pr-136
CREB1down-regulatesR-270-2.13915Pr-4
VBP1up-regulatesR-2099-2.16715Pr-4
TRAF4down-regulatesR-3035-2.1684Pr-17
TRAF4down-regulatesR-3044-2.17055Pr-86
FOXK1down-regulatesR-1194-2.1796Pr-17
FLI1down-regulatesR-7842.19671Pr-137
SRFdown-regulatesR-1778-2.26549Pr-4
CREB1down-regulatesR-278-2.27835Pr-11
RELAdown-regulatesR-1463-2.30399Pr-4
RREB1down-regulatesR-2286-2.31249Pr-17
MAZup-regulatesR-499-2.32628Pr-11
ELF2down-regulatesR-987-2.34496Pr-20
ZNF281down-regulatesR-2482-2.34579Pr-30
NFKB1down-regulatesR-1573-2.35352Pr-4
XBP1up-regulatesR-3061-2.35701Pr-11
NR4A2down-regulatesR-1716-2.35911Pr-17
MAFKdown-regulatesR-2804-2.38089Pr-11
FOXO1down-regulatesR-1399-2.38797Pr-17
SP1up-regulatesR-2723-2.38863Pr-30
BBXdown-regulatesR-15332.412Pr-137
MAFKdown-regulatesR-2799-2.41258Pr-4
NFATC2down-regulatesR-16942.42215Pr-70
POU2F1down-regulatesR-68-2.42589Pr-4
ERFdown-regulatesR-3352.46806Pr-136
SRFdown-regulatesR-1783-2.52212Pr-106

Genes (2)

HPDL, LY6G5B

Regulons (3)

R-2538, R-2243, R-1783

SRFdown-regulatesR-1782-2.52908Pr-15
RREB1down-regulatesR-2297-2.5711Pr-20
GABPB1down-regulatesR-19442.5919Pr-55
ELF2down-regulatesR-970-2.61196Pr-136
NR3C1down-regulatesR-3196-2.61331Pr-101
MEF2Adown-regulatesR-1867-2.61348Pr-86
ZNF281down-regulatesR-2487-2.70466Pr-4
NFATC1down-regulatesR-2202-2.7244Pr-19
NFATC1down-regulatesR-2198-2.73148Pr-11
FLI1down-regulatesR-7952.77664Pr-50
HBP1down-regulatesR-1829-2.78136Pr-17
NFIL3down-regulatesR-1684-2.82079Pr-4
XBP1up-regulatesR-3051-2.85107Pr-4
NFKB1down-regulatesR-1587-2.87374Pr-86
CEBPGdown-regulatesR-446-2.9189Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ZNF143up-regulatesR-23082.93506Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

ETV3down-regulatesR-25302.93772Pr-72
ZNF281down-regulatesR-2478-2.93787Pr-86
NFKB1down-regulatesR-1576-2.95247Pr-86
ERFdown-regulatesR-330-2.95847Pr-101
HINFPdown-regulatesR-2621-2.97505Pr-35
ZBTB7Bup-regulatesR-1232-2.98559Pr-35
E2F2up-regulatesR-2948-3.01545Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

FOXO1down-regulatesR-1405-3.01812Pr-11
FOXK1down-regulatesR-12043.06585Pr-77

Genes (0)

Regulons (4)

R-1204, R-2842, R-1300, R-1549

TRAF4down-regulatesR-30413.08861Pr-50
JDP2down-regulatesR-358-3.10262Pr-17
RREB1down-regulatesR-2288-3.12172Pr-15
RARBup-regulatesR-1104-3.12692Pr-15
MAFKdown-regulatesR-2813-3.12874Pr-4
MEF2Adown-regulatesR-1877-3.20022Pr-38
NFKB1down-regulatesR-1589-3.21935Pr-3
MAZup-regulatesR-5053.21974Pr-70
NR3C1down-regulatesR-3189-3.2767Pr-20
RELAdown-regulatesR-14643.32257Pr-70
NR3C1down-regulatesR-31883.34354Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RELAdown-regulatesR-1465-3.41018Pr-17
MZF1down-regulatesR-3019-3.42244Pr-35
BRCA1up-regulatesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

RREB1down-regulatesR-2292-3.46394Pr-101
STAT3down-regulatesR-307-3.61941Pr-11
ZNF281down-regulatesR-2496-3.6494Pr-104
NFKB1down-regulatesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ENSG00000176887up-regulatesR-18953.70985Pr-50
GABPB1down-regulatesR-1945-3.71816Pr-35
ENSG00000165066up-regulatesR-30813.73477Pr-128
FOXK1down-regulatesR-1196-3.80774Pr-11
SP1up-regulatesR-2726-3.82052Pr-20
HBP1down-regulatesR-18423.856Pr-138
ZNF281down-regulatesR-2484-3.91355Pr-20
GABPB1down-regulatesR-19513.93668Pr-50
SP1up-regulatesR-2734-3.98682Pr-38
MAZup-regulatesR-509-4.01621Pr-42
ZNF143up-regulatesR-23244.09925Pr-50
FOXO1down-regulatesR-1414-4.10459Pr-61
SRFdown-regulatesR-17814.13916Pr-70
E2F8up-regulatesR-16294.14363Pr-136
CEBPGdown-regulatesR-4414.14664Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

HLXdown-regulatesR-2762-4.29241Pr-32
POU2F1down-regulatesR-884.3225Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MEF2Adown-regulatesR-18804.46094Pr-128
ENSG00000176887up-regulatesR-18894.48939Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

FLI1down-regulatesR-794-4.49758Pr-36
RREB1down-regulatesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

POU2F1down-regulatesR-734.62299Pr-70
SP1up-regulatesR-2724-4.65176Pr-110
GRHL1down-regulatesR-3146-4.75189Pr-118
POU2F1down-regulatesR-904.80999Pr-128
MEF2Adown-regulatesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

POU2F1down-regulatesR-864.85124Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-506-4.85353Pr-4
HBP1down-regulatesR-18474.92709Pr-70
ELF2down-regulatesR-9754.96438Pr-74
MAZup-regulatesR-4974.96461Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

ERFdown-regulatesR-3345.11658Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

VDRdown-regulatesR-12315.12816Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FLI1down-regulatesR-7836.1459Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

SP1up-regulatesR-27126.54886Pr-54
SP1up-regulatesR-27196.73271Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

SRFdown-regulatesR-17807.20867Pr-71
PARP1up-regulatesR-26368.12838Pr-68
FOXO1down-regulatesR-13938.37511Pr-68
E2F2up-regulatesR-29428.59906Pr-68
E2F8up-regulatesR-16268.62493Pr-68
E2F8up-regulatesR-16288.73321Pr-71
E2F1up-regulatesR-21738.76486Pr-68
E2F1up-regulatesR-21728.82921Pr-68
E2F2up-regulatesR-29448.90615Pr-68
E2F8up-regulatesR-16279.26408Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions