Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

- forkhead box I1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
ENSG00000168269 E0XEN6

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator:

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
PTPRDactivatesR-1561-0.547918Pr-2
RNASeq_MAFB_CallactivatesR-1561-0.547918Pr-2
t(4;14)activatesR-1561-0.547918Pr-2
TACC2activatesR-1561-0.547918Pr-2
FAM46CactivatesR-1569-0.622926Pr-54
PTPRDactivatesR-1569-0.622926Pr-54
t(11;14)activatesR-1569-0.622926Pr-54
RNASeq_MAFB_CallactivatesR-1569-0.622926Pr-54
t(4;14)activatesR-1569-0.622926Pr-54
t(11;14)_cytogeneticactivatesR-1569-0.622926Pr-54
MYO10activatesR-1560-0.982515Pr-0
PTPRDactivatesR-1560-0.982515Pr-0
t(4;14)activatesR-1560-0.982515Pr-0
TACC2activatesR-1560-0.982515Pr-0
DIS3repressesR-15631.10269Pr-62
IRF4repressesR-15631.10269Pr-62
t(11;14)repressesR-15631.10269Pr-62
t(4;14)repressesR-15631.10269Pr-62
t(11;14)_cytogeneticrepressesR-15631.10269Pr-62
t(4;14)activatesR-15621.13944Pr-7
FAM46CrepressesR-15641.28019Pr-59
MYO10repressesR-15641.28019Pr-59
t(11;14)repressesR-15641.28019Pr-59
RNASeq_MAFB_CallrepressesR-15641.28019Pr-59
SDK1repressesR-15641.28019Pr-59
TACC2repressesR-15641.28019Pr-59
t(11;14)_cytogeneticrepressesR-15641.28019Pr-59
DIS3repressesR-1566-1.63414Pr-65
FAM46CrepressesR-1566-1.63414Pr-65
IRF4repressesR-1566-1.63414Pr-65
PRKD2repressesR-1566-1.63414Pr-65
t(11;14)repressesR-1566-1.63414Pr-65
RNASeq_CCND3_CallrepressesR-1566-1.63414Pr-65
t(11;14)_cytogeneticrepressesR-1566-1.63414Pr-65
FAM46CactivatesR-1570-2.10985Pr-35
PCLOactivatesR-1570-2.10985Pr-35
PTPRDactivatesR-1570-2.10985Pr-35
RNASeq_MAFB_CallactivatesR-1570-2.10985Pr-35
TTNactivatesR-1570-2.10985Pr-35
ZFHX3activatesR-1570-2.10985Pr-35
FAM46CrepressesR-15712.51736Pr-136
IRF4repressesR-15712.51736Pr-136
PRKD2repressesR-15712.51736Pr-136
PTPRDrepressesR-15712.51736Pr-136
t(11;14)repressesR-15712.51736Pr-136
RNASeq_MAFB_CallrepressesR-15712.51736Pr-136
TACC2repressesR-15712.51736Pr-136
TTNrepressesR-15712.51736Pr-136
ZFHX3repressesR-15712.51736Pr-136
t(11;14)_cytogeneticrepressesR-15712.51736Pr-136
MYO10repressesR-1565-3.23366Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

RNASeq_MAFB_CallrepressesR-1565-3.23366Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

t(4;14)repressesR-1565-3.23366Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

DIS3repressesR-15683.70657Pr-50
FAM46CrepressesR-15683.70657Pr-50
IRF4repressesR-15683.70657Pr-50
PTPRDrepressesR-15683.70657Pr-50
RNASeq_MAFB_CallrepressesR-15683.70657Pr-50
TTNrepressesR-15683.70657Pr-50
DIS3activatesR-1567-4.76751Pr-36
FAM46CactivatesR-1567-4.76751Pr-36
IRF4activatesR-1567-4.76751Pr-36
PRKD2activatesR-1567-4.76751Pr-36
t(11;14)activatesR-1567-4.76751Pr-36
RNASeq_MAFB_CallactivatesR-1567-4.76751Pr-36
t(11;14)_cytogeneticactivatesR-1567-4.76751Pr-36

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.