Mutation – Multiple Myeloma Network Portal

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation TRAF3

Regulator	Role	Regulon	Cox Hazard Ratio (Regulon)	Transcriptional Programs
SPI1	down-regulates	R-2619	0.0114715	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
ENSG00000245848	down-regulates	R-1655	0.0553209	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ENSG00000186564	up-regulates	R-479	0.0566846	Pr-41 Genes (9) CABP4, SFN, YES1, CSTF2T, KLHL11, DEXI, SOCS3, HIST2H2BE, ZNF248 Regulons (10) R-1382, R-479, R-1436, R-1086, R-83, R-971, R-1757, R-2378, R-3091, R-677
SP1	up-regulates	R-2730	0.102205	Pr-89 Genes (5) CCDC57, TRIM16L, RGL2, YAE1D1, CRCP Regulons (7) R-2730, R-754, R-2526, R-2146, R-1885, R-2702, R-545
RFX3	down-regulates	R-1666	0.128531	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
NFIL3	down-regulates	R-1686	-0.145704	Pr-25 Genes (9) RNPEP, RUFY1, ZNF664, TRNAU1AP, CLEC4G, SRC, HLA-F, RTL5 Regulons (9) R-974, R-1686, R-160, R-709, R-2312, R-2984, R-2341, R-2802, R-3062
SPI1	down-regulates	R-2610	-0.164598	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
ELF1	down-regulates	R-2981	0.167624	Pr-138 Genes (9) SYNE3, SEC24C, WSCD1, RAP2B, ODF3L1, SEMA4A, SLC9A6, PATL2, C2orf15 Regulons (12) R-1666, R-2981, R-2567, R-1177, R-133, R-3011, R-472, R-11, R-169, R-2271, R-1668, R-1842
ZBTB16	down-regulates	R-589	0.185533	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
IRF7	down-regulates	R-1086	-0.243887	Pr-41 Genes (9) CABP4, SFN, YES1, CSTF2T, KLHL11, DEXI, SOCS3, HIST2H2BE, ZNF248 Regulons (10) R-1382, R-479, R-1436, R-1086, R-83, R-971, R-1757, R-2378, R-3091, R-677
NR2C2	down-regulates	R-1388	-0.247005	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
YY1	down-regulates	R-2527	0.251774	Pr-5 Genes (32) ZNF25, POLD4, CLK2, EPS8L2, PIDD1, JUN, AGTRAP, C2orf69, GRINA, PTPN11, PITPNB, DNAH14, C15orf41, KIF18B, DUSP28, CFAP126, ZFP62, MYO5A, FAM114A1, FAM118B, PIM3, ZNF627, TEX45, ITPRIPL1, MRPL53, TECPR1, RNPS1, CFAP44, ZNF726, EML6, LOC441155 Regulons (33) R-362, R-1924, R-1337, R-92, R-1207, R-3137, R-2527, R-2775, R-2562, R-1927, R-2749, R-2109, R-1198, R-1854, R-275, R-2883, R-3016, R-286, R-1350, R-2038, R-148, R-42, R-3198, R-2569, R-2282, R-581, R-590, R-2346, R-2265, R-2473, R-2377, R-2110, R-1385
ETS1	up-regulates	R-5	-0.284036	Pr-95 Genes (5) EIF3F, ASB8, NDUFV2, METTL23, GM2A Regulons (5) R-45, R-984, R-5, R-1928, R-600
ELF4	down-regulates	R-2333	0.29758	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
MAZ	up-regulates	R-510	0.306813	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
TRAF4	down-regulates	R-3042	-0.342468	Pr-122 Genes (6) NSUN3, EIF3K, ANXA2, LCK, TLR7, PAM16 Regulons (21) R-2218, R-3042, R-2501, R-2962, R-1078, R-1900, R-1098, R-2812, R-2168, R-1712, R-27, R-2760, R-1892, R-680, R-2370, R-1248, R-1693, R-2525, R-2673, R-1772, R-519
SPI1	down-regulates	R-2601	-0.345541	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
IRF9	down-regulates	R-1157	-0.356348	Pr-140 Genes (2) CALR, ENTPD6 Regulons (4) R-1157, R-1672, R-2042, R-1823
ELF4	down-regulates	R-2337	0.389404	Pr-111 Genes (12) PARP10, ZHX2, DNHD1, MRPL54, BRI3BP, TET3, DNAJB13, CDC42SE1, RPL23A, WDHD1 Regulons (12) R-1273, R-1009, R-2956, R-2337, R-983, R-2356, R-711, R-299, R-1708, R-3092, R-2721, R-1074
SP1	up-regulates	R-2732	0.411833	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
CEBPD	down-regulates	R-1312	-0.440834	Pr-126 Genes (12) MTURN, SAMD7, ISG15, TYW1, SFT2D2, PTPRCAP, APOBEC3G, MRPL33, CDK11B, PRR5-ARHGAP8, TERB1, UTP14C Regulons (15) R-1312, R-1710, R-128, R-366, R-2612, R-1442, R-981, R-2739, R-1647, R-1766, R-542, R-2672, R-2543, R-2638, R-3053
HINFP	down-regulates	R-2627	-0.48712	Pr-88 Genes (14) GADD45GIP1, PAK2, D2HGDH, AEN, DHTKD1, KBTBD3, RPS27L, CD47, ZNF587, SFMBT2, DCLRE1A, TCTN1, MEF2B Regulons (16) R-900, R-491, R-893, R-102, R-1247, R-2627, R-2234, R-2684, R-3138, R-368, R-2620, R-104, R-1690, R-1206, R-3142, R-2660
ELF4	down-regulates	R-2344	0.524718	Pr-23 Genes (14) LRRTM4, LMNB2, B3GNT8, HLA-DQB1, TIGD5, FIZ1, C3orf58, CREB3L2, ALG12, BTN3A2, ENTPD5, TBC1D9B Regulons (14) R-2081, R-1884, R-1719, R-1839, R-2182, R-1274, R-2732, R-2344, R-477, R-3190, R-2889, R-309, R-371, R-444
IRF7	down-regulates	R-1093	-0.530543	Pr-46 Genes (3) RELL1, NCKIPSD, ACAD11 Regulons (3) R-1093, R-364, R-2171
MAZ	up-regulates	R-507	0.537629	Pr-129 Genes (12) DALRD3, CTNNBIP1, FAHD1, ZBTB2, SLC2A4, UBA7, KLHDC8B, BCDIN3D, FAM111B, MAN1A2, HYLS1, INF2 Regulons (12) R-356, R-1920, R-2758, R-2274, R-507, R-1886, R-1777, R-1479, R-1180, R-2321, R-756, R-1179
ELF1	down-regulates	R-2984	-0.581395	Pr-25 Genes (9) RNPEP, RUFY1, ZNF664, TRNAU1AP, CLEC4G, SRC, HLA-F, RTL5 Regulons (9) R-974, R-1686, R-160, R-709, R-2312, R-2984, R-2341, R-2802, R-3062
ENSG00000054598	down-regulates	R-1014	0.610294	Pr-33 Genes (6) ZNF620, IMPDH2, SLC35C1, TIGIT, AP2A2, C11orf96 Regulons (6) R-1415, R-2349, R-2893, R-2147, R-1014, R-2205
IRF7	down-regulates	R-1083	0.674001	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
MEF2D	up-regulates	R-877	0.682478	Pr-55 Genes (5) NR2C2AP, KCNK12, RACK1, KLHL23, AARSD1 Regulons (6) R-877, R-129, R-2602, R-478, R-2196, R-1944
SPI1	down-regulates	R-2607	0.699824	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
STAT5A	down-regulates	R-2158	0.702295	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
FLI1	down-regulates	R-786	-0.733394	Pr-59 Genes (15) DRAP1, MRPS23, CBX6, NDUFA12, UBALD2, MUC1, PBX1, PRELP, CFD, MPZL1, TBC1D8, STK38L, PCDHGA5, POC1B-GALNT4 Regulons (18) R-3140, R-2080, R-298, R-786, R-619, R-1472, R-450, R-601, R-2301, R-1564, R-654, R-2795, R-2891, R-3058, R-2183, R-1508, R-2708, R-658
ENSG00000054598	down-regulates	R-1003	0.751126	Pr-7 Genes (38) UFSP1, SLC35G1, IMP3, R3HDM2, RNF135, HKR1, ATP6AP2, SATB1, RBM10, CRELD2, SNRNP35, ZDHHC23, AMER1, PTRHD1, NDUFA6, MAFF, PRMT3, RGPD2, ATP6V0C, C16orf54, IRS2, MKL2, FAM86B2, PRR5, ZNF33A, XRCC6, TSC22D2, SLC6A9, ADAM32, NOL4L, SERPINA1, EME2, ENTPD7, PJA2 Regulons (39) R-1139, R-308, R-1195, R-2247, R-2754, R-1584, R-1923, R-1849, R-2345, R-370, R-226, R-1013, R-2065, R-2181, R-2145, R-2843, R-1003, R-1410, R-2796, R-3012, R-1347, R-3136, R-1650, R-543, R-53, R-2571, R-1879, R-1738, R-2557, R-1968, R-1562, R-3067, R-788, R-1840, R-2230, R-471, R-1667, R-3165, R-361
MAZ	up-regulates	R-500	0.764562	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
STAT1	down-regulates	R-3069	0.785822	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
FLI1	down-regulates	R-792	0.810335	Pr-120 Genes (9) ANKLE2, TMEM52, YOD1, ZNF443, CDCA2, SIVA1, PSMD13, CHAMP1 Regulons (9) R-2299, R-2503, R-2342, R-546, R-2201, R-1346, R-1651, R-792, R-2963
MAFB	down-regulates	R-1730	-0.820291	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ELF1	down-regulates	R-2995	-0.821049	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
MAFB	down-regulates	R-1741	-0.834433	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
IRF9	down-regulates	R-1149	0.851839	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
IRF7	down-regulates	R-1084	-0.861526	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
IRF1	down-regulates	R-182	0.909345	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
ARID3A	up-regulates	R-1340	0.91304	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
HLX	down-regulates	R-2763	0.933948	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
BHLHE40	down-regulates	R-944	0.943222	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
IRF7	down-regulates	R-1092	-0.976053	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
FOXO3	down-regulates	R-2777	-0.982827	Pr-27 Genes (8) AGMO, CALHM6, NHLRC2, DNM3, ITSN1, PLPP6 Regulons (8) R-2493, R-2777, R-1790, R-2323, R-2279, R-2558, R-2815, R-3194
GABPA	down-regulates	R-1456	-1.00351	Pr-37 Genes (13) DNAJC28, TMEM212, C17orf58, HYKK, GTF2E2, ZNF628, ZNF335, KLHL9, GK, SGMS1, INAFM1, CNPY2, LOC100130705 Regulons (17) R-966, R-2494, R-1747, R-1456, R-707, R-698, R-978, R-646, R-1197, R-2144, R-1458, R-652, R-1559, R-294, R-1005, R-2170, R-2498
IRF9	down-regulates	R-1152	-1.01235	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
ELF1	down-regulates	R-2996	-1.04319	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
IRF7	down-regulates	R-1090	-1.0469	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
STAT5A	down-regulates	R-2166	-1.06033	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
IRF1	down-regulates	R-192	-1.06726	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
TRAF4	down-regulates	R-3034	1.06768	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
ETS1	up-regulates	R-13	1.07999	Pr-93 Genes (9) B3GNT5, PLEC, MME, ZNF700, SND1, VEPH1, ZNF480, ZHX1-C8orf76 Regulons (9) R-1522, R-564, R-13, R-1438, R-310, R-3131, R-826, R-2725, R-2630
SP1	up-regulates	R-2713	1.08118	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
IRF9	down-regulates	R-1154	-1.10025	Pr-40 Genes (9) DDX10, GLRX5, BTLA, MCRS1, PDCD1, H2AFX, FBF1, H1F0, GREB1 Regulons (9) R-2801, R-490, R-1084, R-1092, R-1152, R-494, R-1090, R-192, R-1154
ENSG00000178860	down-regulates	R-1099	-1.10178	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
SP1	up-regulates	R-2728	-1.12023	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
IRF1	down-regulates	R-195	-1.1496	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
ARID3A	up-regulates	R-1344	-1.15545	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
KLF7	up-regulates	R-282	-1.16094	Pr-15 Genes (14) RBM33, RUFY4, SLC39A10, RPE, GLMP, MSRB1, BMPR2, SIPA1, VDAC1, EIF6, STON1, PRKDC Regulons (22) R-2088, R-2040, R-2207, R-282, R-2251, R-2946, R-1593, R-2737, R-1470, R-1848, R-1263, R-297, R-989, R-36, R-1782, R-1427, R-2049, R-2191, R-2288, R-1104, R-149, R-2959
RFX3	down-regulates	R-1673	-1.17273	Pr-10 Genes (26) ATAD5, MANEAL, RBM34, MAN2A2, AMZ2, VKORC1L1, TLE1, ANKRD36B, CXorf40B, PCNX3, ENTPD4, FITM2, GFPT1, FICD, R3HDM4, HSPA1B, TMEM231, CDKL4, RAB12, ANKRD28, ZNF844, ERCC6, BORCS8-MEF2B Regulons (27) R-1850, R-2412, R-276, R-1536, R-2572, R-755, R-607, R-2204, R-1353, R-1673, R-903, R-571, R-2217, R-2657, R-2774, R-448, R-2892, R-1205, R-757, R-1976, R-1918, R-2149, R-2491, R-2302, R-274, R-588, R-95
ENSG00000245848	down-regulates	R-1641	1.17618	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
MAZ	up-regulates	R-503	-1.19474	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
SPI1	down-regulates	R-2613	-1.19964	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
ELF4	down-regulates	R-2341	-1.20013	Pr-25 Genes (9) RNPEP, RUFY1, ZNF664, TRNAU1AP, CLEC4G, SRC, HLA-F, RTL5 Regulons (9) R-974, R-1686, R-160, R-709, R-2312, R-2984, R-2341, R-2802, R-3062
SPI1	down-regulates	R-2596	-1.23045	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
RFX3	down-regulates	R-1672	-1.25932	Pr-140 Genes (2) CALR, ENTPD6 Regulons (4) R-1157, R-1672, R-2042, R-1823
IRF9	down-regulates	R-1158	1.2922	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ENSG00000245848	down-regulates	R-1646	1.30305	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
GABPA	down-regulates	R-1455	1.3231	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
ATF2	up-regulates	R-3091	1.32566	Pr-41 Genes (9) CABP4, SFN, YES1, CSTF2T, KLHL11, DEXI, SOCS3, HIST2H2BE, ZNF248 Regulons (10) R-1382, R-479, R-1436, R-1086, R-83, R-971, R-1757, R-2378, R-3091, R-677
YY1	down-regulates	R-2521	1.37423	Pr-58 Genes (28) ZNF135, PLEKHM3, FAM220A, C3orf38, GAS1, SIAH2, GPR132, PDE4B, CDK10, PCYT2, ARHGAP30, SMIM29, FPR3, ZFP69B, C3orf62, NUGGC, FAM53B, IL1RAP, MPHOSPH8, ZNF781, NCOR2, LAMA2, ERI2, HIST1H3J, WWP2, STKLD1, MIF Regulons (28) R-386, R-1756, R-1490, R-817, R-1516, R-1342, R-2943, R-2529, R-959, R-2510, R-1213, R-578, R-641, R-2353, R-2974, R-2982, R-2054, R-833, R-2190, R-657, R-964, R-67, R-2871, R-2195, R-3076, R-2521, R-1894, R-3148
GRHL1	down-regulates	R-3145	-1.37724	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
ELF4	down-regulates	R-2340	-1.40118	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
NR2C2	down-regulates	R-1390	-1.41324	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
FLI1	down-regulates	R-789	-1.43137	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
STAT4	down-regulates	R-2654	-1.46619	Pr-9 Genes (30) SLC26A11, DDX60L, CA13, RAB11B, SOWAHB, GNG2, UBE2H, KIF24, PLSCR1, ANKDD1B, EVL, TECPR2, NF1, SIGLEC15, PCBP2, LOC105369247, ZNF624, S100A10, PLN, CALM1, TTC37, ANKRD13B, ZNF652, RCSD1, ARHGAP11A, DCAF12, SMC5, C10orf128 Regulons (30) R-1534, R-1278, R-2296, R-1107, R-159, R-52, R-1264, R-4, R-1953, R-1718, R-273, R-2166, R-2728, R-195, R-1344, R-503, R-2613, R-1878, R-541, R-2806, R-1583, R-2340, R-2143, R-2480, R-1408, R-2570, R-2061, R-2654, R-1476, R-442
SP3	up-regulates	R-1821	-1.48832	Pr-91 Genes (10) ZNF667, DZIP3, TMX2, BBIP1, C19orf24, HLA-DPA1, SERPINB10, P2RY11, NFE2L1, IRF7 Regulons (12) R-1211, R-1821, R-1822, R-1580, R-824, R-1298, R-2056, R-896, R-2268, R-1085, R-2362, R-3186
ENSG00000054598	down-regulates	R-1004	-1.53439	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
SPI1	down-regulates	R-2602	1.59944	Pr-55 Genes (5) NR2C2AP, KCNK12, RACK1, KLHL23, AARSD1 Regulons (6) R-877, R-129, R-2602, R-478, R-2196, R-1944
MAFB	down-regulates	R-1737	1.60695	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
IRF1	down-regulates	R-199	-1.64611	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
ELF4	down-regulates	R-2332	-1.65183	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ZBTB16	down-regulates	R-590	-1.67399	Pr-5 Genes (32) ZNF25, POLD4, CLK2, EPS8L2, PIDD1, JUN, AGTRAP, C2orf69, GRINA, PTPN11, PITPNB, DNAH14, C15orf41, KIF18B, DUSP28, CFAP126, ZFP62, MYO5A, FAM114A1, FAM118B, PIM3, ZNF627, TEX45, ITPRIPL1, MRPL53, TECPR1, RNPS1, CFAP44, ZNF726, EML6, LOC441155 Regulons (33) R-362, R-1924, R-1337, R-92, R-1207, R-3137, R-2527, R-2775, R-2562, R-1927, R-2749, R-2109, R-1198, R-1854, R-275, R-2883, R-3016, R-286, R-1350, R-2038, R-148, R-42, R-3198, R-2569, R-2282, R-581, R-590, R-2346, R-2265, R-2473, R-2377, R-2110, R-1385
IRF9	down-regulates	R-1155	1.69513	Pr-3 Genes (46) ALG10B, ZNF613, VPS37D, CLVS1, GATD1, ERN1, RPP25, TSHZ1, ZADH2, TIGD2, MIGA1, P2RY13, ZNF101, COA4, CHST15, NOP10, GJC1, DAZAP2, UTP11, DGCR6, SATL1, RBM43, IFNLR1, IRF7, BLOC1S5, PARVB, PIK3R4, ABCB8, DDI2, DACT3, CXorf40A, ZNF277, MICB, NUP62, TSPAN4, MKRN2OS, FAM133B, ST20-MTHFS Regulons (49) R-2619, R-2148, R-3054, R-2410, R-228, R-3004, R-2876, R-1907, R-1191, R-2490, R-2769, R-1000, R-3121, R-1275, R-22, R-2325, R-1866, R-2285, R-1417, R-1960, R-2379, R-71, R-1497, R-1520, R-377, R-3167, R-1699, R-663, R-1069, R-2228, R-2232, R-2112, R-3141, R-836, R-333, R-827, R-194, R-2955, R-2322, R-1155, R-1588, R-586, R-1939, R-1215, R-2532, R-167, R-3010, R-1589, R-829
SPI1	down-regulates	R-2612	1.70161	Pr-126 Genes (12) MTURN, SAMD7, ISG15, TYW1, SFT2D2, PTPRCAP, APOBEC3G, MRPL33, CDK11B, PRR5-ARHGAP8, TERB1, UTP14C Regulons (15) R-1312, R-1710, R-128, R-366, R-2612, R-1442, R-981, R-2739, R-1647, R-1766, R-542, R-2672, R-2543, R-2638, R-3053
ENSG00000186564	up-regulates	R-478	1.71458	Pr-55 Genes (5) NR2C2AP, KCNK12, RACK1, KLHL23, AARSD1 Regulons (6) R-877, R-129, R-2602, R-478, R-2196, R-1944
SP3	up-regulates	R-1822	-1.74298	Pr-91 Genes (10) ZNF667, DZIP3, TMX2, BBIP1, C19orf24, HLA-DPA1, SERPINB10, P2RY11, NFE2L1, IRF7 Regulons (12) R-1211, R-1821, R-1822, R-1580, R-824, R-1298, R-2056, R-896, R-2268, R-1085, R-2362, R-3186
MAZ	up-regulates	R-501	-1.77175	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
MAFB	down-regulates	R-1732	1.82103	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ENSG00000054598	down-regulates	R-1011	1.84026	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ELF4	down-regulates	R-2339	1.84468	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
MAZ	up-regulates	R-495	1.8487	Pr-87 Genes (18) LRRC37A3, PLEKHN1, AGRN, FAM221A, PNRC2, LONP1, HCAR1, NUP62CL, ZNF358, RUFY2, CXorf65, SDHD, FAM216A, C17orf67, FASTKD5, EID1 Regulons (20) R-222, R-1137, R-150, R-1228, R-2331, R-2713, R-3125, R-2052, R-664, R-2897, R-1544, R-2376, R-101, R-617, R-304, R-820, R-495, R-3021, R-1754, R-678
FLI1	down-regulates	R-785	-1.95666	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
PRDM4	up-regulates	R-3075	2.00508	Pr-73 Genes (4) IFITM5, NOL7, HSBP1, CEBPE Regulons (8) R-2102, R-1844, R-3075, R-1760, R-1830, R-173, R-781, R-2770
USF1	up-regulates	R-1862	2.03502	Pr-79 Genes (3) CD2AP, NFAM1, UBE2V1 Regulons (3) R-2216, R-1862, R-2507
IRF7	down-regulates	R-1089	-2.10194	Pr-67 Genes (4) C6orf226, ARPC4, TRMT9B Regulons (5) R-55, R-1075, R-1089, R-2987, R-375
RUNX3	down-regulates	R-892	2.10284	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
ENSG00000186564	up-regulates	R-482	2.10292	Pr-125 Genes (16) RPS6KA3, GBA, HMGN4, CMTM4, TEAD1, BCAM, NIF3L1, MKL1, CR1, RING1, PVRIG, GET4, LOC102724159, PI4KA, SMIM20 Regulons (17) R-589, R-1538, R-54, R-2559, R-2953, R-223, R-1504, R-1914, R-3162, R-2359, R-1975, R-2741, R-2547, R-892, R-482, R-2476, R-1703
PPARG	down-regulates	R-2825	-2.11214	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ENSG00000245848	down-regulates	R-1647	2.18539	Pr-126 Genes (12) MTURN, SAMD7, ISG15, TYW1, SFT2D2, PTPRCAP, APOBEC3G, MRPL33, CDK11B, PRR5-ARHGAP8, TERB1, UTP14C Regulons (15) R-1312, R-1710, R-128, R-366, R-2612, R-1442, R-981, R-2739, R-1647, R-1766, R-542, R-2672, R-2543, R-2638, R-3053
ENSG00000245848	down-regulates	R-1645	2.20823	Pr-32 Genes (4) ATP5MF-PTCD1, ZNF674, TRIM34, ATF1 Regulons (6) R-1645, R-1550, R-1309, R-669, R-1280, R-2762
SP1	up-regulates	R-2733	-2.20943	Pr-20 Genes (5) ZNF530, ERCC6L, NAP1L4, ZNF324B, RNASE4 Regulons (10) R-2300, R-2901, R-1936, R-2733, R-987, R-2297, R-3189, R-166, R-2726, R-2484
ELF1	down-regulates	R-2987	-2.21673	Pr-67 Genes (4) C6orf226, ARPC4, TRMT9B Regulons (5) R-55, R-1075, R-1089, R-2987, R-375
RFX3	down-regulates	R-1676	-2.24353	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
CREB1	up-regulates	R-278	-2.27835	Pr-11 Genes (7) B3GNTL1, JPT2, GPR162, AP5B1, GALNT4, TUBB3, C15orf65 Regulons (22) R-177, R-3025, R-284, R-278, R-499, R-3061, R-2804, R-2079, R-3132, R-2198, R-3173, R-1439, R-2772, R-1966, R-1405, R-603, R-2060, R-2241, R-1921, R-307, R-1196, R-1526
CEBPD	down-regulates	R-1309	2.34003	Pr-32 Genes (4) ATP5MF-PTCD1, ZNF674, TRIM34, ATF1 Regulons (6) R-1645, R-1550, R-1309, R-669, R-1280, R-2762
NR3C1	up-regulates	R-3187	-2.36326	Pr-85 Genes (18) A2M, ANAPC2, NIM1K, ZFAND2A, GCC1, ERCC6L2, UBE2E2, MTA1, TOB2, SNAI3, RINL, SMIM15, SULT1C2, SMG5, SYS1, CDPF1, SLC12A8, ITGB3 Regulons (21) R-2966, R-484, R-3159, R-597, R-661, R-1688, R-1272, R-2328, R-615, R-2366, R-2374, R-2647, R-360, R-977, R-3017, R-1311, R-622, R-3187, R-2071, R-3002, R-2492
PATZ1	down-regulates	R-2196	2.39409	Pr-55 Genes (5) NR2C2AP, KCNK12, RACK1, KLHL23, AARSD1 Regulons (6) R-877, R-129, R-2602, R-478, R-2196, R-1944
ZBTB16	down-regulates	R-593	2.41668	Pr-124 Genes (20) MYPOP, DMAP1, PER1, C1S, DENND5A, TSPYL2, KNTC1, TMEM105, LRCH3, ZBTB6, CFAP73, LILRB4, TNFRSF18, LITAF, ZNF665, IPO7, KMT2B Regulons (20) R-1400, R-1425, R-1962, R-1828, R-991, R-1083, R-1577, R-72, R-2158, R-3069, R-2814, R-1149, R-1631, R-182, R-1340, R-3034, R-3139, R-39, R-199, R-593
BARX2	down-regulates	R-292	-2.43197	Pr-101 Genes (5) ZSCAN30, EFCAB7, ARPC4-TTLL3, HOXA5, BDP1 Regulons (14) R-1496, R-1909, R-840, R-292, R-2138, R-3196, R-1505, R-3182, R-313, R-330, R-1903, R-2161, R-2368, R-2292
SP1	up-regulates	R-2727	2.53149	Pr-62 Genes (12) DTX3, EGR3, NRIP1, CYP4F3, HEXIM1, RNF220, SRSF10, LCOR, TXNRD1, TPM2, SPIB Regulons (13) R-510, R-2382, R-1511, R-126, R-3008, R-2280, R-1151, R-2116, R-1563, R-2512, R-961, R-976, R-2727
ENSG00000179348	down-regulates	R-1058	2.53254	Pr-134 Genes (104) MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1 Regulons (119) R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272
ETV2	down-regulates	R-1508	2.5634	Pr-59 Genes (15) DRAP1, MRPS23, CBX6, NDUFA12, UBALD2, MUC1, PBX1, PRELP, CFD, MPZL1, TBC1D8, STK38L, PCDHGA5, POC1B-GALNT4 Regulons (18) R-3140, R-2080, R-298, R-786, R-619, R-1472, R-450, R-601, R-2301, R-1564, R-654, R-2795, R-2891, R-3058, R-2183, R-1508, R-2708, R-658
ZBTB7B	up-regulates	R-1233	2.59774	Pr-52 Genes (3) LTN1, DHFR Regulons (14) R-2811, R-2250, R-384, R-1233, R-1661, R-2629, R-3077, R-1986, R-1548, R-305, R-2978, R-870, R-2716, R-496
NR3C1	up-regulates	R-3192	-2.64135	Pr-110 Genes (2) FGD6, ARHGAP8 Regulons (18) R-1702, R-2623, R-2755, R-3192, R-605, R-2809, R-1553, R-1749, R-1771, R-2622, R-3001, R-1691, R-3184, R-2724, R-105, R-1349, R-1110, R-1764
RFX3	down-regulates	R-1674	-2.69724	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
FLI1	down-regulates	R-795	2.77664	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
ENSG00000179348	down-regulates	R-1064	-2.78126	Pr-19 Genes (8) COL4A6, HSD17B8, CPT1B, PPM1N, LYN Regulons (11) R-51, R-392, R-789, R-2483, R-2, R-2551, R-501, R-1967, R-1674, R-2202, R-1064
ETV2	down-regulates	R-1507	-2.80802	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
IRF7	down-regulates	R-1091	-2.83714	Pr-135 Genes (24) LYSMD3, MTHFR, NEB, MX2, PCBP3, CHRM5, WDR53, TOR3A, CCDC30, ZDHHC17, SLC38A3, ZNF429, PIWIL2, SLC22A5, MCMBP, PRIM1, SZT2, HNRNPUL2, CEBPD, ATXN1L, N4BP2L2, MARS2 Regulons (38) R-311, R-2304, R-610, R-973, R-901, R-2103, R-341, R-717, R-2293, R-2067, R-337, R-1454, R-979, R-1555, R-2536, R-2985, R-1455, R-2617, R-1956, R-2167, R-791, R-785, R-672, R-2847, R-2083, R-1091, R-1890, R-1299, R-1874, R-2406, R-1269, R-1942, R-389, R-2263, R-1692, R-2199, R-1523, R-1230
RFX3	down-regulates	R-1664	-2.83731	Pr-103 Genes (2) HMGN1, ADM5 Regulons (10) R-224, R-1763, R-2481, R-1153, R-1664, R-3172, R-475, R-365, R-1701, R-3023
ELK4	up-regulates	R-766	-2.86246	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
RFX3	down-regulates	R-1661	2.92167	Pr-52 Genes (3) LTN1, DHFR Regulons (14) R-2811, R-2250, R-384, R-1233, R-1661, R-2629, R-3077, R-1986, R-1548, R-305, R-2978, R-870, R-2716, R-496
NR3C1	up-regulates	R-3186	-2.93135	Pr-91 Genes (10) ZNF667, DZIP3, TMX2, BBIP1, C19orf24, HLA-DPA1, SERPINB10, P2RY11, NFE2L1, IRF7 Regulons (12) R-1211, R-1821, R-1822, R-1580, R-824, R-1298, R-2056, R-896, R-2268, R-1085, R-2362, R-3186
NR3C1	up-regulates	R-3180	-2.95291	Pr-94 Genes (3) NPW, C8orf88, KLF16 Regulons (8) R-1852, R-1282, R-2289, R-1176, R-3180, R-357, R-1402, R-1428
MAZ	up-regulates	R-513	-2.96542	Pr-44 Genes (0) Regulons (7) R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280
HINFP	down-regulates	R-2621	-2.97505	Pr-35 Genes (10) ZBTB7A, TMEM107, BHLHA15, GLTPD2, ZNF395, MAFB, SMIM13, AKAP2, FOX3A Regulons (20) R-2747, R-3059, R-336, R-2624, R-1948, R-14, R-277, R-2826, R-1570, R-1094, R-1244, R-2621, R-1232, R-1506, R-3019, R-493, R-1945, R-2691, R-1963, R-2244
ELF1	down-regulates	R-2986	2.98171	Pr-74 Genes (1) MAP1LC3B2 Regulons (9) R-2514, R-2986, R-712, R-2759, R-285, R-343, R-995, R-2615, R-975
ELK4	up-regulates	R-769	-3.00912	Pr-102 Genes (10) CCR4, KPNA4, NANOS3, NHLRC1, HIST3H2BB, DDX42, SH3D21, ZNF345, PINX1, CCPG1 Regulons (13) R-367, R-985, R-553, R-2155, R-2062, R-1380, R-2947, R-1355, R-1937, R-3060, R-769, R-522, R-2706
TCF4	up-regulates	R-3002	-3.03869	Pr-85 Genes (18) A2M, ANAPC2, NIM1K, ZFAND2A, GCC1, ERCC6L2, UBE2E2, MTA1, TOB2, SNAI3, RINL, SMIM15, SULT1C2, SMG5, SYS1, CDPF1, SLC12A8, ITGB3 Regulons (21) R-2966, R-484, R-3159, R-597, R-661, R-1688, R-1272, R-2328, R-615, R-2366, R-2374, R-2647, R-360, R-977, R-3017, R-1311, R-622, R-3187, R-2071, R-3002, R-2492
FLI1	down-regulates	R-781	3.05111	Pr-73 Genes (4) IFITM5, NOL7, HSBP1, CEBPE Regulons (8) R-2102, R-1844, R-3075, R-1760, R-1830, R-173, R-781, R-2770
PITX1	down-regulates	R-659	-3.05142	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
IRF1	down-regulates	R-197	3.05156	Pr-132 Genes (3) CHRM4, MAP3K3, BCKDHA Regulons (7) R-44, R-1378, R-2219, R-1352, R-898, R-2756, R-197
ENSG00000179348	down-regulates	R-1065	3.08491	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
TRAF4	down-regulates	R-3041	3.08861	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
FLI1	down-regulates	R-780	-3.11957	Pr-36 Genes (1) LTB4R Regulons (25) R-56, R-1510, R-329, R-1898, R-1507, R-766, R-2752, R-340, R-1779, R-312, R-780, R-965, R-1752, R-124, R-679, R-1775, R-626, R-794, R-168, R-2740, R-1567, R-518, R-2111, R-2277, R-2545
IRF1	down-regulates	R-181	3.21843	Pr-8 Genes (12) F2R, NPLOC4, COA5, TMEM17, MESP2, SLC29A3, CPNE1, RBM14, ADSL, CNTF, MRPL46, SRXN1 Regulons (25) R-2994, R-1711, R-449, R-2248, R-1649, R-1658, R-3028, R-2489, R-1433, R-94, R-632, R-2548, R-3020, R-3006, R-2051, R-233, R-3160, R-665, R-181, R-75, R-2633, R-2210, R-2434, R-1060, R-230
IRF8	down-regulates	R-2633	3.29667	Pr-8 Genes (12) F2R, NPLOC4, COA5, TMEM17, MESP2, SLC29A3, CPNE1, RBM14, ADSL, CNTF, MRPL46, SRXN1 Regulons (25) R-2994, R-1711, R-449, R-2248, R-1649, R-1658, R-3028, R-2489, R-1433, R-94, R-632, R-2548, R-3020, R-3006, R-2051, R-233, R-3160, R-665, R-181, R-75, R-2633, R-2210, R-2434, R-1060, R-230
FOXO3	down-regulates	R-2771	-3.30433	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
ENSG00000186564	up-regulates	R-481	-3.30778	Pr-45 Genes (2) NDUFA4L2, UCKL1 Regulons (5) R-2504, R-174, R-25, R-229, R-481
IRF7	down-regulates	R-1087	3.35543	Pr-114 Genes (3) PCGF5, SAMD11, KCTD21 Regulons (7) R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107
ENSG00000054598	down-regulates	R-1017	-3.3625	Pr-4 Genes (37) B3GNT4, ZNF575, CRACR2B, ALS2CL, TCAIM, MED14, ADO, SFXN4, TM2D3, GAS2L1, EIF4EBP1, COL4A5, LRRK2, MXD3, ZBED8, CFAP97D1, WDR92, TMEM141, USP51, ZNF260, MTRNR2L8, CLLU1, CHURC1, CEP95, MRPL12, RPS10-NUDT3, YY1, BACH2, E2F2 Regulons (47) R-295, R-2879, R-2639, R-2318, R-3043, R-1908, R-1695, R-1554, R-2485, R-1767, R-777, R-443, R-1753, R-2114, R-1585, R-2824, R-1670, R-560, R-293, R-773, R-2432, R-270, R-2099, R-778, R-1778, R-1633, R-1277, R-1463, R-818, R-176, R-1573, R-1468, R-2599, R-2799, R-68, R-2950, R-2767, R-1174, R-990, R-2658, R-2221, R-2487, R-1684, R-3051, R-2813, R-1017, R-506
TRIM28	down-regulates	R-1506	-3.3709	Pr-35 Genes (10) ZBTB7A, TMEM107, BHLHA15, GLTPD2, ZNF395, MAFB, SMIM13, AKAP2, FOX3A Regulons (20) R-2747, R-3059, R-336, R-2624, R-1948, R-14, R-277, R-2826, R-1570, R-1094, R-1244, R-2621, R-1232, R-1506, R-3019, R-493, R-1945, R-2691, R-1963, R-2244
PPARG	down-regulates	R-2829	3.43725	Pr-48 Genes (0) Regulons (17) R-1901, R-1219, R-1558, R-2381, R-1896, R-2829, R-667, R-871, R-76, R-498, R-2885, R-2549, R-2975, R-2078, R-2904, R-2152, R-2495
IRF9	down-regulates	R-1156	-3.43888	Pr-47 Genes (0) Regulons (5) R-591, R-2773, R-1156, R-1897, R-2520
IRF1	down-regulates	R-187	-3.69641	Pr-100 Genes (3) GPATCH8, UVRAG, TEN1 Regulons (15) R-485, R-3145, R-1097, R-3161, R-819, R-74, R-1423, R-1397, R-1761, R-2771, R-1868, R-2511, R-187, R-2287, R-2692
ELF1	down-regulates	R-2978	3.77589	Pr-52 Genes (3) LTN1, DHFR Regulons (14) R-2811, R-2250, R-384, R-1233, R-1661, R-2629, R-3077, R-1986, R-1548, R-305, R-2978, R-870, R-2716, R-496
SP1	up-regulates	R-2726	-3.82052	Pr-20 Genes (5) ZNF530, ERCC6L, NAP1L4, ZNF324B, RNASE4 Regulons (10) R-2300, R-2901, R-1936, R-2733, R-987, R-2297, R-3189, R-166, R-2726, R-2484
FOX3A	up-regulates	R-1514	3.87415	Pr-49 Genes (0) Regulons (12) R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965
SP1	up-regulates	R-2716	3.88928	Pr-52 Genes (3) LTN1, DHFR Regulons (14) R-2811, R-2250, R-384, R-1233, R-1661, R-2629, R-3077, R-1986, R-1548, R-305, R-2978, R-870, R-2716, R-496
TCF4	up-regulates	R-2998	3.92524	Pr-75 Genes (2) CCDC85B, THAP7 Regulons (8) R-1182, R-1186, R-2477, R-1943, R-1912, R-2107, R-960, R-2998
SP3	up-regulates	R-1823	-3.92809	Pr-140 Genes (2) CALR, ENTPD6 Regulons (4) R-1157, R-1672, R-2042, R-1823
SP1	up-regulates	R-2734	-3.98682	Pr-38 Genes (3) KCMF1, TGM2, B3GNT9 Regulons (12) R-376, R-227, R-655, R-158, R-584, R-659, R-1877, R-710, R-620, R-1774, R-2734, R-2516
ELF1	down-regulates	R-2983	4.09607	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
ENSG00000179348	down-regulates	R-1060	4.11532	Pr-8 Genes (12) F2R, NPLOC4, COA5, TMEM17, MESP2, SLC29A3, CPNE1, RBM14, ADSL, CNTF, MRPL46, SRXN1 Regulons (25) R-2994, R-1711, R-449, R-2248, R-1649, R-1658, R-3028, R-2489, R-1433, R-94, R-632, R-2548, R-3020, R-3006, R-2051, R-233, R-3160, R-665, R-181, R-75, R-2633, R-2210, R-2434, R-1060, R-230
HINFP	down-regulates	R-2622	-4.19383	Pr-110 Genes (2) FGD6, ARHGAP8 Regulons (18) R-1702, R-2623, R-2755, R-3192, R-605, R-2809, R-1553, R-1749, R-1771, R-2622, R-3001, R-1691, R-3184, R-2724, R-105, R-1349, R-1110, R-1764
SPI1	down-regulates	R-2615	4.23457	Pr-74 Genes (1) MAP1LC3B2 Regulons (9) R-2514, R-2986, R-712, R-2759, R-285, R-343, R-995, R-2615, R-975
TCF4	up-regulates	R-3001	-4.24514	Pr-110 Genes (2) FGD6, ARHGAP8 Regulons (18) R-1702, R-2623, R-2755, R-3192, R-605, R-2809, R-1553, R-1749, R-1771, R-2622, R-3001, R-1691, R-3184, R-2724, R-105, R-1349, R-1110, R-1764
TCF4	up-regulates	R-2997	-4.26614	Pr-17 Genes (10) DNAJC9, PPP5D1, RNF103, NFS1, IFITM10, ZCCHC3, HMBS, SMIM6, CORO7, CUX1 Regulons (16) R-1961, R-385, R-1001, R-3124, R-3035, R-1194, R-2286, R-1716, R-1399, R-598, R-1829, R-2330, R-358, R-1465, R-470, R-2997
MAZ	up-regulates	R-498	4.36616	Pr-48 Genes (0) Regulons (17) R-1901, R-1219, R-1558, R-2381, R-1896, R-2829, R-667, R-871, R-76, R-498, R-2885, R-2549, R-2975, R-2078, R-2904, R-2152, R-2495
ELF1	down-regulates	R-2976	4.38806	Pr-70 Genes (1) SNURF Regulons (12) R-1694, R-505, R-1464, R-296, R-1781, R-2976, R-1469, R-73, R-942, R-1847, R-2281, R-2992
NR3C1	up-regulates	R-3184	-4.39801	Pr-110 Genes (2) FGD6, ARHGAP8 Regulons (18) R-1702, R-2623, R-2755, R-3192, R-605, R-2809, R-1553, R-1749, R-1771, R-2622, R-3001, R-1691, R-3184, R-2724, R-105, R-1349, R-1110, R-1764
SPI1	down-regulates	R-2611	4.52776	Pr-49 Genes (0) Regulons (12) R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965
STAT4	down-regulates	R-2653	4.54157	Pr-114 Genes (3) PCGF5, SAMD11, KCTD21 Regulons (7) R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107
RFX3	down-regulates	R-1665	4.55866	Pr-69 Genes (1) KLF13 Regulons (9) R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719
NFAT5	down-regulates	R-47	4.65172	Pr-49 Genes (0) Regulons (12) R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965
ENSG00000179348	down-regulates	R-1068	4.67578	Pr-50 Genes (1) TMEM45A Regulons (17) R-1899, R-795, R-1065, R-3041, R-2276, R-2113, R-2384, R-1973, R-1568, R-1895, R-2554, R-1951, R-2983, R-2324, R-38, R-1068, R-537
BHLHE40	down-regulates	R-942	4.74639	Pr-70 Genes (1) SNURF Regulons (12) R-1694, R-505, R-1464, R-296, R-1781, R-2976, R-1469, R-73, R-942, R-1847, R-2281, R-2992
GRHL1	down-regulates	R-3146	-4.75189	Pr-118 Genes (18) ZNF169, CCDC121, LCORL, CUEDC1, ZBTB44, MIER1, ECI2, C4orf47, ZNF611, ERV3-1, HIGD1C, TOMM6, CSKMT, SMIM1, POU5F2, DPP3, EBLN2 Regulons (25) R-388, R-1185, R-2333, R-841, R-967, R-2625, R-125, R-1390, R-2192, R-1859, R-2750, R-1922, R-1788, R-842, R-1521, R-2694, R-131, R-1957, R-694, R-787, R-2413, R-2213, R-2689, R-1379, R-3146
ELF1	down-regulates	R-2975	4.75926	Pr-48 Genes (0) Regulons (17) R-1901, R-1219, R-1558, R-2381, R-1896, R-2829, R-667, R-871, R-76, R-498, R-2885, R-2549, R-2975, R-2078, R-2904, R-2152, R-2495
ARID3A	up-regulates	R-1349	-4.86595	Pr-110 Genes (2) FGD6, ARHGAP8 Regulons (18) R-1702, R-2623, R-2755, R-3192, R-605, R-2809, R-1553, R-1749, R-1771, R-2622, R-3001, R-1691, R-3184, R-2724, R-105, R-1349, R-1110, R-1764
MAZ	up-regulates	R-497	4.96461	Pr-49 Genes (0) Regulons (12) R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965
IRF7	down-regulates	R-1088	5.08481	Pr-63 Genes (2) GNL1, IFI30 Regulons (9) R-1974, R-1208, R-3082, R-2214, R-1785, R-2722, R-2174, R-1088, R-2194
FLI1	down-regulates	R-783	6.1459	Pr-69 Genes (1) KLF13 Regulons (9) R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719
SP1	up-regulates	R-2719	6.73271	Pr-69 Genes (1) KLF13 Regulons (9) R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

Causal Mechanistic Flows for Mutation TRAF3

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Genes (104)

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