Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation RNASeq_MAFB_Call

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
TEAD1down-regulatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

NR2F6down-regulatesR-13820.010612Pr-41
ENSG00000186564up-regulatesR-4790.0566846Pr-41
TRAF4down-regulatesR-3037-0.0698997Pr-2
SP1up-regulatesR-2717-0.0948824Pr-2
SREBF1up-regulatesR-11390.101608Pr-7
SP1up-regulatesR-27300.102205Pr-89
ENSG00000186564up-regulatesR-4840.109277Pr-85
PLAG1down-regulatesR-15220.140759Pr-93
NFIL3down-regulatesR-1686-0.145704Pr-25
HOXA3down-regulatesR-222-0.14701Pr-87
SP1up-regulatesR-27140.199684Pr-109
HSF2down-regulatesR-3159-0.213586Pr-85
SOX4down-regulatesR-21870.253475Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

SPIBup-regulatesR-670-0.26844Pr-92
ETS1up-regulatesR-5-0.284036Pr-95

Genes (5)

EIF3F, ASB8, NDUFV2, METTL23, GM2A

Regulons (5)

R-45, R-984, R-5, R-1928, R-600

ATF1up-regulatesR-5640.297759Pr-93
ZNF281down-regulatesR-2479-0.333368Pr-2
ATF3down-regulatesR-24110.339529Pr-2
NFE2L1up-regulatesR-1825-0.343609Pr-2
HSF1down-regulatesR-49-0.350252Pr-2
HMBOX1up-regulatesR-23820.378178Pr-62
SPIBup-regulatesR-6610.39364Pr-85
MEF2Adown-regulatesR-1869-0.397022Pr-2
HMGA1down-regulatesR-8320.407077Pr-119

Genes (4)

GPBAR1, RHD, GMFB, C5AR1

Regulons (4)

R-832, R-1181, R-58, R-164

MLXup-regulatesR-3197-0.407624Pr-0
ETS1up-regulatesR-12-0.427939Pr-60
MAFup-regulatesR-1020.468356Pr-88
HINFPdown-regulatesR-2627-0.48712Pr-88
MEF2Adown-regulatesR-1866-0.518528Pr-3
RREB1down-regulatesR-2285-0.538758Pr-3
NFKB1down-regulatesR-1574-0.538784Pr-2
ENSG00000168269down-regulatesR-1561-0.547918Pr-2
SPDEFdown-regulatesR-1960-0.548684Pr-3
NFATC2up-regulatesR-16880.551677Pr-85
MEF2Adown-regulatesR-18720.561055Pr-56
FOXO1down-regulatesR-14110.58467Pr-60
SMAD3up-regulatesR-2962-0.592902Pr-122
HSF1down-regulatesR-50-0.599033Pr-16
RREB1down-regulatesR-2283-0.618728Pr-2
ENSG00000168269down-regulatesR-1569-0.622926Pr-54
ZNF281down-regulatesR-2485-0.64174Pr-4
HSF2down-regulatesR-31670.645152Pr-3
RREB1down-regulatesR-2300-0.646333Pr-20
MYBup-regulatesR-6150.668149Pr-85
HMBOX1up-regulatesR-2378-0.732226Pr-41
TFCP2up-regulatesR-1699-0.734782Pr-3
MEF2Adown-regulatesR-18750.748013Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

RREB1down-regulatesR-2296-0.757232Pr-9
SMAD3up-regulatesR-2960-0.759716Pr-90
HSF1down-regulatesR-51-0.803656Pr-19
SOX4down-regulatesR-2186-0.80587Pr-22
MAZup-regulatesR-508-0.810173Pr-0
NFYCup-regulatesR-3000.814081Pr-130
STAT5Bup-regulatesR-23660.819111Pr-85
ETS1up-regulatesR-7-0.82093Pr-64
HSF1down-regulatesR-52-0.875962Pr-9
ENSG00000186564up-regulatesR-4850.883356Pr-100
SREBF1up-regulatesR-11370.963749Pr-87
NFYCup-regulatesR-299-0.964307Pr-111
NFKB1down-regulatesR-1585-1.04936Pr-4
MYBup-regulatesR-6241.05914Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ETS1up-regulatesR-131.07999Pr-93
SP1up-regulatesR-27131.08118Pr-87
HMGA1down-regulatesR-8331.0818Pr-58
SOX4down-regulatesR-2184-1.09056Pr-113
SP1up-regulatesR-2728-1.12023Pr-9
ATF1up-regulatesR-562-1.1286Pr-0
HMGA1down-regulatesR-8261.24266Pr-93
MAFGup-regulatesR-1491-1.24402Pr-112
MEF2Adown-regulatesR-1878-1.24921Pr-9
ETV6up-regulatesR-698-1.25265Pr-37
ZNF281down-regulatesR-2488-1.25749Pr-0
ENSG00000168269down-regulatesR-15641.28019Pr-59
CREB3L2down-regulatesR-521-1.29128Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

NFIAup-regulatesR-3531.30799Pr-90
ETS1up-regulatesR-101.31637Pr-109
KLF13down-regulatesR-2041-1.31925Pr-42
SPIBup-regulatesR-6641.32468Pr-87
SP1up-regulatesR-27251.37906Pr-93
MEF2Adown-regulatesR-1888-1.38486Pr-22
NFKB1down-regulatesR-1583-1.38564Pr-9
ETS1up-regulatesR-81.3888Pr-96
ZNF281down-regulatesR-2480-1.41308Pr-9
FOXO1down-regulatesR-1408-1.42694Pr-9
NR3C1up-regulatesR-3193-1.45371Pr-86
HMGA1down-regulatesR-825-1.46299Pr-66

Genes (3)

SHISAL2A, USP7, RUNDC1

Regulons (3)

R-2776, R-1184, R-825

SP3up-regulatesR-1821-1.48832Pr-91
MAFup-regulatesR-1041.49044Pr-88
HOXA3down-regulatesR-2271.49853Pr-38
SMAD4up-regulatesR-23591.51133Pr-125
ETS1up-regulatesR-3-1.52284Pr-90
ENSG00000186564up-regulatesR-4831.55638Pr-1
MAFup-regulatesR-1011.56978Pr-87
HMGA1down-regulatesR-8221.59236Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

NFATC2up-regulatesR-1690-1.61477Pr-88
MYBup-regulatesR-6171.6152Pr-87
ETS1up-regulatesR-1-1.61913Pr-64
MYBup-regulatesR-6231.65419Pr-96
RREB1down-regulatesR-2303-1.65549Pr-113
EWSR1down-regulatesR-2551-1.6617Pr-19
SREBF1up-regulatesR-11401.67284Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FOXJ3down-regulatesR-2894-1.67584Pr-113
EWSR1down-regulatesR-25501.72058Pr-56
HSF1down-regulatesR-56-1.77472Pr-36
HMGA1down-regulatesR-8201.79517Pr-87
ATF1up-regulatesR-560-1.81953Pr-4
POU2F2down-regulatesR-2517-1.83475Pr-113
MAZup-regulatesR-4951.8487Pr-87
E2F2up-regulatesR-29451.88745Pr-133
NFYCup-regulatesR-293-1.90832Pr-4
MYBup-regulatesR-622-1.933Pr-85
HMGA1down-regulatesR-824-1.97932Pr-91
SOX4down-regulatesR-2185-1.98014Pr-0
SMAD3up-regulatesR-2967-1.98807Pr-139
PLAG1down-regulatesR-1521-2.02883Pr-118
NR3C1up-regulatesR-31792.06628Pr-60
MEF2Adown-regulatesR-1885-2.09865Pr-89
ENSG00000186564up-regulatesR-4822.10292Pr-125
ENSG00000168269down-regulatesR-1570-2.10985Pr-35
SPIBup-regulatesR-672-2.17589Pr-135
SP1up-regulatesR-2733-2.20943Pr-20
SMAD4up-regulatesR-23542.22929Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

SRFdown-regulatesR-1778-2.26549Pr-4
SPDEFdown-regulatesR-1967-2.26981Pr-19
HINFPdown-regulatesR-2628-2.29875Pr-42
HMGA1down-regulatesR-8342.30843Pr-136
HMGA1down-regulatesR-818-2.31588Pr-4
NFKB1down-regulatesR-1573-2.35352Pr-4
SOX4down-regulatesR-2183-2.35721Pr-59
NR3C1up-regulatesR-3187-2.36326Pr-85
ENSG00000087510up-regulatesR-2630-2.36566Pr-93
SPIBup-regulatesR-668-2.41677Pr-90
ENSG00000168269down-regulatesR-15712.51736Pr-136
FLI1down-regulatesR-7932.52326Pr-96
ETV2down-regulatesR-1510-2.52918Pr-36
ERFdown-regulatesR-329-2.5417Pr-36
RREB1down-regulatesR-2297-2.5711Pr-20
ZBTB7Bup-regulatesR-12332.59774Pr-52
NR3C1up-regulatesR-3192-2.64135Pr-110
MEF2Dup-regulatesR-8742.64324Pr-1
ZNF281down-regulatesR-2487-2.70466Pr-4
ETS1up-regulatesR-92.77231Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FLI1down-regulatesR-7952.77664Pr-50
PEBP1up-regulatesR-17552.80711Pr-1
ETV2down-regulatesR-1507-2.80802Pr-36
TFCP2up-regulatesR-1703-2.82074Pr-125
HSF4down-regulatesR-1732.83222Pr-73
SREBF1up-regulatesR-1136-2.84396Pr-86
ELK4up-regulatesR-766-2.86246Pr-36
PLAG1down-regulatesR-1528-2.89171Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

ETV6up-regulatesR-694-2.92866Pr-118
SOX4down-regulatesR-21772.93862Pr-108
ENSG00000087510up-regulatesR-26292.94655Pr-52
NR3C1up-regulatesR-3180-2.95291Pr-94
MAFGup-regulatesR-14932.9536Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

ERFdown-regulatesR-330-2.95847Pr-101
HINFPdown-regulatesR-2621-2.97505Pr-35
FLI1down-regulatesR-787-3.00169Pr-118
SPIBup-regulatesR-676-3.00251Pr-112
ELK4up-regulatesR-769-3.00912Pr-102
PEBP1up-regulatesR-17543.03268Pr-87
SRFdown-regulatesR-1779-3.05603Pr-36
TRAF4down-regulatesR-30413.08861Pr-50
FLI1down-regulatesR-780-3.11957Pr-36
HMBOX1up-regulatesR-23813.13315Pr-48
POU2F2down-regulatesR-2519-3.13355Pr-104
STAT5Bup-regulatesR-2368-3.16004Pr-101
MEF2Adown-regulatesR-1877-3.20022Pr-38
MAZup-regulatesR-5053.21974Pr-70
ETS1up-regulatesR-63.22139Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

JDP2up-regulatesR-357-3.22307Pr-94
NR2F6down-regulatesR-1377-3.229Pr-137
ENSG00000168269down-regulatesR-1565-3.23366Pr-98

Genes (2)

QTRT1

Regulons (3)

R-65, R-1552, R-1565

MEF2Adown-regulatesR-1874-3.26785Pr-135
ETV6up-regulatesR-710-3.28784Pr-38
SPIBup-regulatesR-6783.32159Pr-87
SP1up-regulatesR-27153.33045Pr-78

Genes (2)

STIMATE, DDOST

Regulons (6)

R-1941, R-2744, R-656, R-2715, R-2072, R-1512

FOXO1down-regulatesR-1413-3.33652Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

MYBup-regulatesR-620-3.37541Pr-38
PEBP1up-regulatesR-1752-3.39081Pr-36
SPIBup-regulatesR-677-3.40986Pr-41
RREB1down-regulatesR-2292-3.46394Pr-101
MYBup-regulatesR-6253.48247Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

SPDEFdown-regulatesR-19733.49659Pr-50
SPDEFdown-regulatesR-1971-3.6364Pr-113
NFKB1down-regulatesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ENSG00000168269down-regulatesR-15683.70657Pr-50
EWSR1down-regulatesR-25543.72615Pr-50
NFATC2up-regulatesR-16933.7397Pr-122
SP1up-regulatesR-2726-3.82052Pr-20
MEF2Dup-regulatesR-8703.82168Pr-52
SP1up-regulatesR-27163.88928Pr-52
SRFdown-regulatesR-17913.92786Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

SPIBup-regulatesR-6733.97206Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

SP1up-regulatesR-2734-3.98682Pr-38
MAZup-regulatesR-509-4.01621Pr-42
SPIBup-regulatesR-6674.06751Pr-48
NFIAup-regulatesR-3554.10051Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

FOXO1down-regulatesR-1414-4.10459Pr-61
HOXA3down-regulatesR-2254.12962Pr-128
SRFdown-regulatesR-17814.13916Pr-70
MAZup-regulatesR-4964.15346Pr-52
SPDEFdown-regulatesR-1963-4.23229Pr-35
MYBup-regulatesR-626-4.24578Pr-36
NFATC2up-regulatesR-1691-4.27235Pr-110
SP1up-regulatesR-27314.29242Pr-18
SP1up-regulatesR-2735-4.34716Pr-42
ATF1up-regulatesR-566-4.35783Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

MAZup-regulatesR-4984.36616Pr-48
NR2F6down-regulatesR-1381-4.38369Pr-42
MEF2Adown-regulatesR-18804.46094Pr-128
RREB1down-regulatesR-22954.58723Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

SP1up-regulatesR-2724-4.65176Pr-110
NFATC2up-regulatesR-1692-4.70958Pr-135
GRHL1down-regulatesR-3146-4.75189Pr-118
ENSG00000168269down-regulatesR-1567-4.76751Pr-36
MEF2Adown-regulatesR-18734.83919Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-506-4.85353Pr-4
MAZup-regulatesR-4974.96461Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAZup-regulatesR-5045.11311Pr-53

Genes (1)

MEX3C

Regulons (8)

R-1101, R-1493, R-1913, R-2890, R-673, R-2085, R-2524, R-504

POU2F2down-regulatesR-2516-5.21606Pr-38
SREBF1up-regulatesR-1138-5.22607Pr-104
SPDEFdown-regulatesR-19655.28567Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

SRFdown-regulatesR-1787-5.29074Pr-104
MYBup-regulatesR-621-5.47246Pr-104
MAFup-regulatesR-1065.50825Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

SP1up-regulatesR-2720-6.02354Pr-104
PLAG1down-regulatesR-1523-6.09323Pr-135
POU2F2down-regulatesR-25188.01545Pr-68
PARP1up-regulatesR-26368.12838Pr-68
E2F2up-regulatesR-29448.90615Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions