Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation RELN

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
CEBPBup-regulatesR-1768-0.337185Pr-109
NF1down-regulatesR-1300.381224Pr-109
MAFup-regulatesR-1020.468356Pr-88
E2F2up-regulatesR-2943-0.530398Pr-58
MAZup-regulatesR-5070.537629Pr-129
MAFBdown-regulatesR-1730-0.820291Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

PAX5down-regulatesR-23740.983647Pr-85
GABPAup-regulatesR-1457-1.11979Pr-137
ETS2down-regulatesR-19021.14348Pr-136
CEBPBup-regulatesR-17621.16852Pr-127
ENSG00000165066down-regulatesR-3076-1.21549Pr-58
NFIAup-regulatesR-3531.30799Pr-90
GABPAup-regulatesR-14551.3231Pr-135
GABPAup-regulatesR-14521.4809Pr-136
MAFup-regulatesR-1041.49044Pr-88
MZF1down-regulatesR-30261.49051Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

MZF1down-regulatesR-30171.54275Pr-85
VBP1up-regulatesR-21021.67538Pr-73
ATF5up-regulatesR-2404-1.7554Pr-136
MAFBdown-regulatesR-17421.75933Pr-117
ENSG00000165066down-regulatesR-30841.77633Pr-137
ENSG00000087510up-regulatesR-2631-1.77831Pr-130
PPARGdown-regulatesR-2826-1.9597Pr-35
ZNF740down-regulatesR-3841.98118Pr-52
ZBTB7Bup-regulatesR-12332.59774Pr-52
ZBTB7Bup-regulatesR-1232-2.98559Pr-35
MAZup-regulatesR-5053.21974Pr-70
TRIM28down-regulatesR-1506-3.3709Pr-35
MZF1down-regulatesR-3019-3.42244Pr-35
CEBPBup-regulatesR-17724.02047Pr-122
MAZup-regulatesR-4964.15346Pr-52
MAZup-regulatesR-4984.36616Pr-48
MAZup-regulatesR-506-4.85353Pr-4
MAZup-regulatesR-4974.96461Pr-49

Genes (0)

Regulons (12)

R-1473, R-1514, R-441, R-1889, R-2611, R-2295, R-47, R-37, R-1873, R-86, R-497, R-1965

MAFBdown-regulatesR-17435.34371Pr-72
MAFup-regulatesR-1065.50825Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

MZF1down-regulatesR-30246.08041Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

PARP1up-regulatesR-26368.12838Pr-68
E2F2up-regulatesR-29448.90615Pr-68

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions