Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation DST

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
RFX3down-regulatesR-16660.128531Pr-138
IRF7down-regulatesR-1086-0.243887Pr-41
YY1down-regulatesR-25270.251774Pr-5
ELF1down-regulatesR-2979-0.300753Pr-64
ZNF219down-regulatesR-2218-0.320998Pr-122
ENSG00000162367up-regulatesR-1709-0.432129Pr-90
KLF4down-regulatesR-27530.461265Pr-60
IRF7down-regulatesR-10830.674001Pr-124
STAT4down-regulatesR-2652-0.687593Pr-109
STAT1down-regulatesR-30690.785822Pr-124
IRF9down-regulatesR-11490.851839Pr-124
IRF7down-regulatesR-1084-0.861526Pr-40
ZBTB16down-regulatesR-578-0.879917Pr-58
IRF1down-regulatesR-1820.909345Pr-124
ARID3Aup-regulatesR-13400.91304Pr-124
SMAD4down-regulatesR-2353-0.946769Pr-58
IRF7down-regulatesR-1092-0.976053Pr-40
SATB1down-regulatesR-1073-0.977079Pr-64
ELF1down-regulatesR-2974-0.977147Pr-58
SATB1down-regulatesR-10801.00536Pr-130
ELF1down-regulatesR-29821.00653Pr-58
IRF9down-regulatesR-1152-1.01235Pr-40
SOX4down-regulatesR-21801.02925Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

PBX1down-regulatesR-21121.03594Pr-3
IRF7down-regulatesR-1090-1.0469Pr-40
IRF1down-regulatesR-192-1.06726Pr-40
IRF9down-regulatesR-1154-1.10025Pr-40
ESRRGdown-regulatesR-24351.13858Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

SATB1down-regulatesR-10781.15122Pr-122
PATZ1down-regulatesR-2195-1.15328Pr-58
ZNF219down-regulatesR-22161.32424Pr-79

Genes (3)

CD2AP, NFAM1, UBE2V1

Regulons (3)

R-2216, R-1862, R-2507

SATB1down-regulatesR-1079-1.37895Pr-109
ARID3Aup-regulatesR-13451.3836Pr-137
SMAD4down-regulatesR-23581.49431Pr-117
RFX3down-regulatesR-16571.68517Pr-60
SATB1down-regulatesR-1075-1.88885Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

RFX3down-regulatesR-16752.03925Pr-121

Genes (3)

KPNA2, KIAA0040, ATP6V1E2

Regulons (3)

R-1958, R-1675, R-996

IRF7down-regulatesR-1089-2.10194Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

RUNX3down-regulatesR-8922.10284Pr-125
ENSG00000186564up-regulatesR-4822.10292Pr-125
ELF1down-regulatesR-2987-2.21673Pr-67

Genes (4)

C6orf226, ARPC4, TRMT9B

Regulons (5)

R-55, R-1075, R-1089, R-2987, R-375

ARID3Aup-regulatesR-13382.23222Pr-60
ZNF740down-regulatesR-397-2.24578Pr-139
PATZ1down-regulatesR-21962.39409Pr-55
ZBTB16down-regulatesR-5932.41668Pr-124
RFX3down-regulatesR-1674-2.69724Pr-19
RFX3down-regulatesR-16612.92167Pr-52
SOX4down-regulatesR-21772.93862Pr-108
ELF1down-regulatesR-29862.98171Pr-74
FOXJ1up-regulatesR-1851-3.04919Pr-44

Genes (0)

Regulons (7)

R-1193, R-513, R-2948, R-1851, R-3018, R-332, R-280

NR2F6up-regulatesR-1377-3.229Pr-137
ENSG00000186564up-regulatesR-481-3.30778Pr-45

Genes (2)

NDUFA4L2, UCKL1

Regulons (5)

R-2504, R-174, R-25, R-229, R-481

TEAD1down-regulatesR-12143.31075Pr-108
IRF7down-regulatesR-10873.35543Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

TRIM28down-regulatesR-1506-3.3709Pr-35
STAT4down-regulatesR-2655-3.72135Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

ELF1down-regulatesR-29783.77589Pr-52
TEAD1down-regulatesR-1218-3.91201Pr-112
SOX4down-regulatesR-21784.19485Pr-108
ZNF219down-regulatesR-22144.26397Pr-63
ELF1down-regulatesR-2980-4.39203Pr-61
STAT4down-regulatesR-26534.54157Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

RFX3down-regulatesR-16654.55866Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

IRF7down-regulatesR-10885.08481Pr-63
VDRdown-regulatesR-12315.12816Pr-76

Genes (1)

Regulons (7)

R-1140, R-9, R-1791, R-355, R-1231, R-106, R-3024

VDRdown-regulatesR-1230-6.13961Pr-135

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions