Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation CYLD

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
TRAF4up-regulatesR-3042-0.342468Pr-122
ENSG00000177374up-regulatesR-23640.342897Pr-139
ETS1up-regulatesR-12-0.427939Pr-60
KLF4down-regulatesR-27530.461265Pr-60
BBXup-regulatesR-1534-0.482476Pr-9
CEBPBdown-regulatesR-1767-0.661208Pr-4
ETS1up-regulatesR-7-0.82093Pr-64
CEBPBdown-regulatesR-1777-0.838666Pr-129
TCF3down-regulatesR-2067-0.873555Pr-135
BBXup-regulatesR-15320.944278Pr-16
CREB1up-regulatesR-273-1.05492Pr-9
SPDEFup-regulatesR-1977-1.08293Pr-97

Genes (5)

THAP5, HMGB1, KPNA5, ATG9A, GLI4

Regulons (5)

R-2187, R-1977, R-1209, R-3026, R-2354

TRAF4up-regulatesR-3036-1.23044Pr-112
DLX4down-regulatesR-1987-1.23929Pr-86
FOXP1up-regulatesR-31281.29587Pr-16
ETS1up-regulatesR-101.31637Pr-109
ETS1up-regulatesR-81.3888Pr-96
FOSL1up-regulatesR-27951.60011Pr-59
ETS1up-regulatesR-1-1.61913Pr-64
SPDEFup-regulatesR-1961-1.74175Pr-17
MZF1up-regulatesR-30271.86359Pr-108
TEAD1down-regulatesR-1215-2.0223Pr-3
NR3C1up-regulatesR-31792.06628Pr-60
TCF3down-regulatesR-2056-2.11546Pr-91
FOXP1up-regulatesR-3124-2.15985Pr-17
TRAF4up-regulatesR-3035-2.1684Pr-17
ARID3Aup-regulatesR-13382.23222Pr-60
RUNX2down-regulatesR-1282-2.24394Pr-94
ENSG00000136574down-regulatesR-36-2.24791Pr-15
SPDEFup-regulatesR-1967-2.26981Pr-19
ZNF691down-regulatesR-30052.31507Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

RUNX2down-regulatesR-12832.3191Pr-123
NR4A2up-regulatesR-1716-2.35911Pr-17
TRAF4up-regulatesR-3040-2.51251Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

ENSG00000136574down-regulatesR-33-2.57564Pr-86
TCF3down-regulatesR-2050-2.70711Pr-86
TCF3down-regulatesR-2049-2.72112Pr-15
NFATC1up-regulatesR-2202-2.7244Pr-19
ENSG00000177374up-regulatesR-2362-2.78315Pr-91
ARID3Aup-regulatesR-13392.78755Pr-123
NR3C1up-regulatesR-3186-2.93135Pr-91
SOX4down-regulatesR-21772.93862Pr-108
NR3C1up-regulatesR-3180-2.95291Pr-94
PBX1down-regulatesR-21063.00005Pr-123
ETS1up-regulatesR-63.22139Pr-81

Genes (0)

Regulons (4)

R-1351, R-2993, R-6, R-625

ENSG00000128652down-regulatesR-22593.22334Pr-108
PBX1down-regulatesR-21053.24509Pr-108
ENSG00000128652down-regulatesR-22623.31057Pr-108
TEAD1down-regulatesR-12143.31075Pr-108
CEBPBdown-regulatesR-17593.59248Pr-108
TEAD1down-regulatesR-12163.63699Pr-108
ENSG00000136574down-regulatesR-353.65653Pr-123
ENSG00000136574down-regulatesR-343.74664Pr-108
ENSG00000177374up-regulatesR-23633.91579Pr-108
SOX4down-regulatesR-21784.19485Pr-108

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions