Mutation

List of causal flows influenced by the mutation.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulon that contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Mutation BAI3

RegulatorRoleRegulonCox Hazard Ratio (Regulon)Transcriptional Programs
IRF1down-regulatesR-177-0.0462797Pr-11
FOXO1down-regulatesR-14150.265962Pr-33
ELF4down-regulatesR-23490.277486Pr-33
IRF1down-regulatesR-1910.280655Pr-16
ELF4down-regulatesR-23330.29758Pr-118
HMBOX1up-regulatesR-23820.378178Pr-62
SOX4down-regulatesR-2182-0.40215Pr-23
ELF4down-regulatesR-23440.524718Pr-23
STAT4down-regulatesR-2652-0.687593Pr-109
TCF4down-regulatesR-29990.734651Pr-131
PBX1down-regulatesR-2109-0.833545Pr-5
CREB5down-regulatesR-7740.871832Pr-1
HMBOX1up-regulatesR-2383-0.967695Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

ENSG00000165066up-regulatesR-30800.967824Pr-131
NFKB1down-regulatesR-1578-0.969867Pr-65
ETV2down-regulatesR-15091.05383Pr-60
SOX4down-regulatesR-2184-1.09056Pr-113
STAT3down-regulatesR-3101.16096Pr-93
SOX4down-regulatesR-21791.18112Pr-117
PLAG1down-regulatesR-15171.22016Pr-108
CREB3L2down-regulatesR-521-1.29128Pr-107

Genes (3)

HIST4H4, BRK1, OCLM

Regulons (4)

R-521, R-2523, R-3056, R-154

IRF1down-regulatesR-199-1.64611Pr-124
STAT4down-regulatesR-2656-1.67476Pr-0
TCF4down-regulatesR-3000-1.68762Pr-105
FOXO1down-regulatesR-1412-1.97656Pr-28
SOX4down-regulatesR-2185-1.98014Pr-0
CREB5down-regulatesR-773-2.00879Pr-4
ELF4down-regulatesR-2338-2.11243Pr-113
RUNX2down-regulatesR-1282-2.24394Pr-94
RUNX2down-regulatesR-12832.3191Pr-123
ETV2down-regulatesR-15082.5634Pr-59
KLF4down-regulatesR-2755-2.59765Pr-110
PLAG1down-regulatesR-15182.66482Pr-108
IRF1down-regulatesR-1852.8096Pr-123
ELF4down-regulatesR-2348-2.83012Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

SOX4down-regulatesR-21772.93862Pr-108
PBX1down-regulatesR-21063.00005Pr-123
FOXO1down-regulatesR-1405-3.01812Pr-11
FOXO1down-regulatesR-1397-3.23803Pr-100
PBX1down-regulatesR-21053.24509Pr-108
FOXO1down-regulatesR-1413-3.33652Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

IRF1down-regulatesR-1793.48115Pr-108
STAT3down-regulatesR-3033.51898Pr-108
STAT4down-regulatesR-26503.59414Pr-123
TEAD1down-regulatesR-12163.63699Pr-108
ENSG00000136574down-regulatesR-353.65653Pr-123
STAT4down-regulatesR-2655-3.72135Pr-115

Genes (0)

Regulons (7)

R-2348, R-1201, R-962, R-1413, R-1229, R-2655, R-566

PLAG1down-regulatesR-15273.7556Pr-54
TEAD1down-regulatesR-1218-3.91201Pr-112
TCF4down-regulatesR-3001-4.24514Pr-110
ELF1down-regulatesR-29764.38806Pr-70
PLAG1down-regulatesR-1526-4.47157Pr-11
STAT4down-regulatesR-26534.54157Pr-114

Genes (3)

PCGF5, SAMD11, KCTD21

Regulons (7)

R-48, R-2383, R-624, R-231, R-1087, R-2653, R-107

Mutation Causal Mechanistic Flow Network

Cytoscape network of the causal flows influenced by the mutation.

Influences from mutations (magenta chevrons) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Mutation Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions