Regulon R-2105

Cytoscape network of causal flows connected to this regulon. Influences from mutations (green diamonds) to regulators (blue triangles) and then from regulators to the given regulon (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.

Causal Mechanistic Flow Network

Regulon Summary

Summary of module influences

Regulons are regulatory units consisting of a coherently expressed set of genes and the associated regulator(s) whose binding site(s) they share. Regulon summary table displays all associated information related to the specific regulon including the number of genes in the regulon, Hazard ratio, its Regulator, the Transcriptional Program that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any.

GenesCox Hazard RatioRegulatorsCausal FlowsTranscriptional ProgramDrugsMechanism of ActionHallmarksTarget Class
203.24509120Pr-108

Causal Flows

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow a mutation may causally activates or deactivates a downstream regulator which then might up- or down-regulates a regulon that contains genes with similar expression profiles and binding sites.

MutationRoleRegulatorRoleRegulonHazard Ratio
BAI3down-regulatesPBX1activatesR-21053.24509
CYLDdown-regulatesPBX1activatesR-21053.24509
DIS3up-regulatesPBX1activatesR-21053.24509
DUSP2down-regulatesPBX1activatesR-21053.24509
FGFR3up-regulatesPBX1activatesR-21053.24509
GPR98down-regulatesPBX1activatesR-21053.24509
KDM3Bdown-regulatesPBX1activatesR-21053.24509
LTBup-regulatesPBX1activatesR-21053.24509
MUC16down-regulatesPBX1activatesR-21053.24509
MYH2down-regulatesPBX1activatesR-21053.24509
NRASdown-regulatesPBX1activatesR-21053.24509
PRKD2up-regulatesPBX1activatesR-21053.24509
PTPRDdown-regulatesPBX1activatesR-21053.24509
RNASeq_FGFR3_Callup-regulatesPBX1activatesR-21053.24509
MYCdown-regulatesPBX1activatesR-21053.24509
t(4;14)up-regulatesPBX1activatesR-21053.24509
RYR1down-regulatesPBX1activatesR-21053.24509
amp1qup-regulatesPBX1activatesR-21053.24509
del13up-regulatesPBX1activatesR-21053.24509
t(4;14)_cytogeneticup-regulatesPBX1activatesR-21053.24509

Regulon Genes

List of genes that are included in the regulon. These genes have similar expression profiles in subset of patients and they share common binding motif for the Regulator of the regulon. Clicking on the gene name will take you to the gene specific page with more details. Please wait while information is collated from several resources after you click.

Regulon Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions