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Causal Mechanistic Flows with BRCA1 as Regulator

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
TP53	up-regulates	BRCA1	activates	R-1032	1.10039	7	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
t(14;16)_cytogenetic	up-regulates	BRCA1	activates	R-1032	1.10039	7	Pr-117 Genes (51) LRRC25, MRPL48, CNTD1, EFCAB5, ZDHHC13, PPFIA3, TBL1XR1, IL17RA, POLR2L, KLHL28, SHARPIN, PHLDA2, IST1, SKA2, JRKL, TRMT12, WDR27, ADSSL1, SHC4, YTHDF3, ZNF267, OR2AG2, PTAR1, SLX4, PRPF40A, RABL6, ANXA4, WDR5B, MAFG, TOPORS, KCNMB2, MFAP3L, PHACTR4, TRIQK, SUPT4H1, LTC4S, DDX47, FIS1, CKLF, FAM185A, RARB, IRF4, HOXA3 Regulons (53) R-2087, R-1556, R-2707, R-342, R-2610, R-2252, R-62, R-1904, R-1388, R-1266, R-2882, R-369, R-451, R-1677, R-1495, R-1591, R-771, R-2371, R-2535, R-1846, R-945, R-500, R-986, R-2995, R-2886, R-630, R-2738, R-2991, R-1735, R-1032, R-643, R-2069, R-1485, R-2179, R-2961, R-157, R-2336, R-2142, R-2358, R-1271, R-1489, R-1734, R-2090, R-1742, R-2070, R-3168, R-2704, R-994, R-2335, R-1786, R-539, R-2068, R-1929
HUWE1	up-regulates	BRCA1	represses	R-1033	-2.58375	6	Pr-12 Genes (14) CDK5R1, C18orf32, ARL6IP4, NELFA, INTS5, TCEAL9, ZNF431, ZNF81, FAM49A, ARMH1, C2CD4A, GIGYF2, SPIRE2, TMA7 Regulons (17) R-776, R-1187, R-3181, R-555, R-2154, R-2189, R-1434, R-189, R-3127, R-2242, R-1403, R-281, R-2291, R-2193, R-1033, R-1861, R-2245
t(11;14)	up-regulates	BRCA1	represses	R-1033	-2.58375	6	Pr-12 Genes (14) CDK5R1, C18orf32, ARL6IP4, NELFA, INTS5, TCEAL9, ZNF431, ZNF81, FAM49A, ARMH1, C2CD4A, GIGYF2, SPIRE2, TMA7 Regulons (17) R-776, R-1187, R-3181, R-555, R-2154, R-2189, R-1434, R-189, R-3127, R-2242, R-1403, R-281, R-2291, R-2193, R-1033, R-1861, R-2245
TP53	up-regulates	BRCA1	represses	R-1033	-2.58375	6	Pr-12 Genes (14) CDK5R1, C18orf32, ARL6IP4, NELFA, INTS5, TCEAL9, ZNF431, ZNF81, FAM49A, ARMH1, C2CD4A, GIGYF2, SPIRE2, TMA7 Regulons (17) R-776, R-1187, R-3181, R-555, R-2154, R-2189, R-1434, R-189, R-3127, R-2242, R-1403, R-281, R-2291, R-2193, R-1033, R-1861, R-2245
t(11;14)_cytogenetic	up-regulates	BRCA1	represses	R-1033	-2.58375	6	Pr-12 Genes (14) CDK5R1, C18orf32, ARL6IP4, NELFA, INTS5, TCEAL9, ZNF431, ZNF81, FAM49A, ARMH1, C2CD4A, GIGYF2, SPIRE2, TMA7 Regulons (17) R-776, R-1187, R-3181, R-555, R-2154, R-2189, R-1434, R-189, R-3127, R-2242, R-1403, R-281, R-2291, R-2193, R-1033, R-1861, R-2245
DIS3	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
DNAH10	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
FRAS1	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
IRF4	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
LTB	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
PRKD2	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
t(11;14)	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
RNASeq_FGFR3_Call	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
t(4;14)	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
TP53	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
ZNF208	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
amp1q	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
t(11;14)_cytogenetic	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
t(4;14)_cytogenetic	up-regulates	BRCA1	activates	R-1031	2.71498	7	Pr-123 Genes (5) ADGRG1, FADS3, ZC3H11A, RTEL1 Regulons (19) R-943, R-2260, R-514, R-1283, R-1375, R-1547, R-1031, R-1339, R-1706, R-185, R-23, R-2106, R-2367, R-1056, R-616, R-2650, R-1443, R-35, R-220
DIS3	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
DNAH10	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
FAT3	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
IRF4	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
MACF1	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
PRKD2	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
t(11;14)	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
RNASeq_FGFR3_Call	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
t(14;16)	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
t(4;14)	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
TP53	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
t(11;14)_cytogenetic	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
t(14;16)_cytogenetic	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604
t(4;14)_cytogenetic	up-regulates	BRCA1	represses	R-1030	-3.4552	8	Pr-26 Genes (2) TEDC1, ZNF688 Regulons (7) R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

Causal Mechanistic Flows with regulons containing BRCA1

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
DIS3	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
DNAH10	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
FGFR3	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
LTB	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
MUC16	down-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
MYH2	down-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
NRAS	down-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
PRKD2	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
RNASeq_FGFR3_Call	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
t(4;14)	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
amp1q	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
del13	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
t(4;14)_cytogenetic	up-regulates	ENSG00000102678	activates	R-232	5.31311	6	Pr-108 Genes (9) EXT1, DUSP8, TSPYL4, PSMD12, SGTB, PHB2, TMEM242, TMEM238, FOS Regulons (49) R-3052, R-2626, R-660, R-1517, R-1106, R-2339, R-3027, R-196, R-897, R-1502, R-3088, R-1284, R-1518, R-1519, R-382, R-609, R-868, R-2177, R-1424, R-875, R-2475, R-2259, R-1301, R-2105, R-2729, R-1055, R-2262, R-1214, R-2632, R-2209, R-1067, R-179, R-303, R-1689, R-2137, R-1744, R-1759, R-2761, R-1216, R-34, R-1640, R-1731, R-2363, R-502, R-2686, R-2178, R-1740, R-232, R-618
DCHS1	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
DIS3	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
FAM46C	down-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
FAT3	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
FGFR3	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
IRF4	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
RNASeq_FGFR3_Call	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
t(14;16)	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
t(4;14)	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
TRIO	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
amp1q	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
t(4;14)_cytogenetic	up-regulates	SP1	activates	R-2712	6.54886	36	Pr-54 Genes (4) CCDC125, SNX2, C8orf44, C12orf74 Regulons (6) R-1569, R-2568, R-758, R-1930, R-1527, R-2712
IRF4	up-regulates	RARA	activates	R-152	6.62924	19	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(11;14)	up-regulates	RARA	activates	R-152	6.62924	19	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
del13	up-regulates	RARA	activates	R-152	6.62924	19	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(11;14)_cytogenetic	up-regulates	RARA	activates	R-152	6.62924	19	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(11;14)	up-regulates	FOXP1	activates	R-3122	6.78787	34	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(14;16)	up-regulates	FOXP1	activates	R-3122	6.78787	34	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
amp1q	up-regulates	FOXP1	activates	R-3122	6.78787	34	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
del13	up-regulates	FOXP1	activates	R-3122	6.78787	34	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
del1p	up-regulates	FOXP1	activates	R-3122	6.78787	34	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(11;14)_cytogenetic	up-regulates	FOXP1	activates	R-3122	6.78787	34	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
BRAF	up-regulates	FOXJ3	activates	R-2875	7.15409	36	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(11;14)	up-regulates	FOXJ3	activates	R-2875	7.15409	36	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
RNASeq_FGFR3_Call	up-regulates	FOXJ3	activates	R-2875	7.15409	36	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(4;14)	up-regulates	FOXJ3	activates	R-2875	7.15409	36	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
amp1q	up-regulates	FOXJ3	activates	R-2875	7.15409	36	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
del13	up-regulates	FOXJ3	activates	R-2875	7.15409	36	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(11;14)_cytogenetic	up-regulates	FOXJ3	activates	R-2875	7.15409	36	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
DIS3	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
DNAH10	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
FAM46C	up-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
FAT3	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
FRAS1	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
IRF4	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
PRKD2	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(11;14)	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
RNASeq_FGFR3_Call	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(14;16)	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(4;14)	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
TP53	down-regulates	SRF	represses	R-1780	7.20867	35	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(11;14)	up-regulates	FOXJ2	activates	R-1426	7.44142	32	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(14;16)	up-regulates	FOXJ2	activates	R-1426	7.44142	32	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
t(4;14)	up-regulates	FOXJ2	activates	R-1426	7.44142	32	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
amp1q	up-regulates	FOXJ2	activates	R-1426	7.44142	32	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
del13	up-regulates	FOXJ2	activates	R-1426	7.44142	32	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
MAX	up-regulates	TCF3	activates	R-2048	7.44347	39	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
NFKB2	down-regulates	TCF3	activates	R-2048	7.44347	39	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
ZNF208	up-regulates	TCF3	activates	R-2048	7.44347	39	Pr-71 Genes (2) MAGED1, RNASEK Regulons (11) R-2115, R-1557, R-2261, R-152, R-3122, R-2875, R-1780, R-1426, R-2048, R-1071, R-1628
ZNF208	up-regulates	TCF3	activates	R-2043	8.36323	138	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
AHNAK2	down-regulates	FOXO1	represses	R-1393	8.37511	107	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
FAT3	down-regulates	FOXO1	represses	R-1393	8.37511	107	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
MACF1	down-regulates	FOXO1	represses	R-1393	8.37511	107	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
TACC2	down-regulates	FOXO1	represses	R-1393	8.37511	107	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
t(14;16)_cytogenetic	down-regulates	FOXO1	represses	R-1393	8.37511	107	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
t(14;16)	up-regulates	ELK1	activates	R-635	8.4777	54	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627
del1p	up-regulates	ELK1	activates	R-635	8.4777	54	Pr-68 Genes (0) Regulons (18) R-283, R-2319, R-1096, R-2518, R-2636, R-1931, R-2043, R-1393, R-2046, R-635, R-614, R-2942, R-1626, R-1384, R-2173, R-2172, R-2944, R-1627

Causal Mechanistic Flows regulated by Mutation in BRCA1

Causal Mechanistic Flows with BRCA1 as Regulator

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Regulons (7)

Genes (2)

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Regulons (49)

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