Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

TEAD1 - TEA domain transcription factor 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
7003 ENSG00000187079 TEAD1 E9PKB7

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: TEAD1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
FGFR3TEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

GPR98TEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

KDM3BTEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

LTBTEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

t(11;14)TEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

RNASeq_FGFR3_CallTEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

RNASeq_MAFB_CallTEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

t(14;16)TEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

t(4;14)TEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

t(11;14)_cytogeneticTEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

t(4;14)_cytogeneticTEAD1activatesR-1217-0.00924721Pr-116

Genes (3)

CLCF1, RDH14

Regulons (3)

R-1217, R-1537, R-3195

FGFR3TEAD1repressesR-1213-0.831814Pr-58
t(11;14)TEAD1repressesR-1213-0.831814Pr-58
RNASeq_FGFR3_CallTEAD1repressesR-1213-0.831814Pr-58
t(4;14)TEAD1repressesR-1213-0.831814Pr-58
amp1qTEAD1repressesR-1213-0.831814Pr-58
del13TEAD1repressesR-1213-0.831814Pr-58
t(11;14)_cytogeneticTEAD1repressesR-1213-0.831814Pr-58
t(4;14)_cytogeneticTEAD1repressesR-1213-0.831814Pr-58
CYLDTEAD1repressesR-1215-2.0223Pr-3
FGFR3TEAD1repressesR-1215-2.0223Pr-3
t(11;14)TEAD1repressesR-1215-2.0223Pr-3
RNASeq_FGFR3_CallTEAD1repressesR-1215-2.0223Pr-3
t(4;14)TEAD1repressesR-1215-2.0223Pr-3
t(11;14)_cytogeneticTEAD1repressesR-1215-2.0223Pr-3
t(4;14)_cytogeneticTEAD1repressesR-1215-2.0223Pr-3
DIS3TEAD1activatesR-12193.01346Pr-48
FGFR3TEAD1activatesR-12193.01346Pr-48
LTBTEAD1activatesR-12193.01346Pr-48
t(11;14)TEAD1activatesR-12193.01346Pr-48
RNASeq_FGFR3_CallTEAD1activatesR-12193.01346Pr-48
t(4;14)TEAD1activatesR-12193.01346Pr-48
amp1qTEAD1activatesR-12193.01346Pr-48
del13TEAD1activatesR-12193.01346Pr-48
t(11;14)_cytogeneticTEAD1activatesR-12193.01346Pr-48
t(4;14)_cytogeneticTEAD1activatesR-12193.01346Pr-48
CSMD1TEAD1activatesR-12143.31075Pr-108
CYLDTEAD1activatesR-12143.31075Pr-108
DIS3TEAD1activatesR-12143.31075Pr-108
DSTTEAD1activatesR-12143.31075Pr-108
FGFR3TEAD1activatesR-12143.31075Pr-108
GPR98TEAD1activatesR-12143.31075Pr-108
KDM3BTEAD1activatesR-12143.31075Pr-108
LTBTEAD1activatesR-12143.31075Pr-108
MUC16TEAD1activatesR-12143.31075Pr-108
MYH2TEAD1activatesR-12143.31075Pr-108
NRASTEAD1activatesR-12143.31075Pr-108
PRKD2TEAD1activatesR-12143.31075Pr-108
RNASeq_FGFR3_CallTEAD1activatesR-12143.31075Pr-108
t(4;14)TEAD1activatesR-12143.31075Pr-108
RYR1TEAD1activatesR-12143.31075Pr-108
SDK1TEAD1activatesR-12143.31075Pr-108
amp1qTEAD1activatesR-12143.31075Pr-108
del13TEAD1activatesR-12143.31075Pr-108
t(4;14)_cytogeneticTEAD1activatesR-12143.31075Pr-108
BAI3TEAD1activatesR-12163.63699Pr-108
CYLDTEAD1activatesR-12163.63699Pr-108
DIS3TEAD1activatesR-12163.63699Pr-108
EYSTEAD1activatesR-12163.63699Pr-108
FGFR3TEAD1activatesR-12163.63699Pr-108
GPR98TEAD1activatesR-12163.63699Pr-108
KDM3BTEAD1activatesR-12163.63699Pr-108
KMT2BTEAD1activatesR-12163.63699Pr-108
LTBTEAD1activatesR-12163.63699Pr-108
NRASTEAD1activatesR-12163.63699Pr-108
PRKD2TEAD1activatesR-12163.63699Pr-108
t(11;14)TEAD1activatesR-12163.63699Pr-108
RNASeq_FGFR3_CallTEAD1activatesR-12163.63699Pr-108
RNASeq_MAFA_CallTEAD1activatesR-12163.63699Pr-108
t(14;16)TEAD1activatesR-12163.63699Pr-108
t(4;14)TEAD1activatesR-12163.63699Pr-108
RYR1TEAD1activatesR-12163.63699Pr-108
SDK1TEAD1activatesR-12163.63699Pr-108
amp1qTEAD1activatesR-12163.63699Pr-108
del13TEAD1activatesR-12163.63699Pr-108
t(11;14)_cytogeneticTEAD1activatesR-12163.63699Pr-108
t(4;14)_cytogeneticTEAD1activatesR-12163.63699Pr-108
BAI3TEAD1activatesR-1218-3.91201Pr-112
DSTTEAD1activatesR-1218-3.91201Pr-112
FGFR3TEAD1activatesR-1218-3.91201Pr-112
KDM3BTEAD1activatesR-1218-3.91201Pr-112
t(11;14)TEAD1activatesR-1218-3.91201Pr-112
RNASeq_FGFR3_CallTEAD1activatesR-1218-3.91201Pr-112
RNASeq_MAFA_CallTEAD1activatesR-1218-3.91201Pr-112
t(4;14)TEAD1activatesR-1218-3.91201Pr-112
t(11;14)_cytogeneticTEAD1activatesR-1218-3.91201Pr-112
t(4;14)_cytogeneticTEAD1activatesR-1218-3.91201Pr-112

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.