Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

ETV6 - ETS variant transcription factor 6

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
2120 ENSG00000139083 ETV6 H0YG25

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: ETV6

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
t(14;16)ETV6activatesR-7090.35629Pr-25
AHNAK2ETV6activatesR-7000.401784Pr-24
ASXL3ETV6activatesR-7000.401784Pr-24
del13ETV6activatesR-7000.401784Pr-24
AHNAK2ETV6repressesR-7040.469439Pr-137
PCDH10ETV6repressesR-7040.469439Pr-137
del1pETV6repressesR-7040.469439Pr-137
ASXL3ETV6activatesR-697-0.542759Pr-6
t(14;16)ETV6activatesR-697-0.542759Pr-6
t(4;14)ETV6activatesR-697-0.542759Pr-6
amp1qETV6activatesR-697-0.542759Pr-6
del13ETV6activatesR-697-0.542759Pr-6
del1pETV6repressesR-7110.781643Pr-111
PCDH10ETV6repressesR-717-0.825555Pr-135
RNASeq_FGFR3_CallETV6repressesR-717-0.825555Pr-135
t(4;14)ETV6repressesR-717-0.825555Pr-135
amp1qETV6repressesR-717-0.825555Pr-135
del13ETV6repressesR-717-0.825555Pr-135
t(4;14)_cytogeneticETV6repressesR-717-0.825555Pr-135
RNASeq_FGFR3_CallETV6repressesR-708-0.873811Pr-39
t(14;16)ETV6repressesR-708-0.873811Pr-39
t(4;14)ETV6repressesR-708-0.873811Pr-39
amp1qETV6repressesR-708-0.873811Pr-39
del13ETV6repressesR-708-0.873811Pr-39
t(4;14)_cytogeneticETV6repressesR-708-0.873811Pr-39
ASXL3ETV6activatesR-7010.890088Pr-13
amp1qETV6activatesR-7010.890088Pr-13
del13ETV6activatesR-7010.890088Pr-13
del1pETV6activatesR-7010.890088Pr-13
RNASeq_FGFR3_CallETV6repressesR-707-1.22268Pr-37
t(14;16)ETV6repressesR-707-1.22268Pr-37
t(4;14)ETV6repressesR-707-1.22268Pr-37
amp1qETV6repressesR-707-1.22268Pr-37
del13ETV6repressesR-707-1.22268Pr-37
t(4;14)_cytogeneticETV6repressesR-707-1.22268Pr-37
ATMETV6repressesR-698-1.25265Pr-37
RNASeq_FGFR3_CallETV6repressesR-698-1.25265Pr-37
RNASeq_MAFB_CallETV6repressesR-698-1.25265Pr-37
t(14;16)ETV6repressesR-698-1.25265Pr-37
t(4;14)ETV6repressesR-698-1.25265Pr-37
amp1qETV6repressesR-698-1.25265Pr-37
del13ETV6repressesR-698-1.25265Pr-37
t(4;14)_cytogeneticETV6repressesR-698-1.25265Pr-37
MAGEC1ETV6repressesR-7061.28845Pr-131
RNASeq_FGFR3_CallETV6repressesR-7061.28845Pr-131
t(4;14)ETV6repressesR-7061.28845Pr-131
amp1qETV6repressesR-7061.28845Pr-131
del13ETV6repressesR-7061.28845Pr-131
del1pETV6repressesR-7061.28845Pr-131
t(4;14)_cytogeneticETV6repressesR-7061.28845Pr-131
amp1qETV6repressesR-702-1.51819Pr-136
del13ETV6repressesR-702-1.51819Pr-136
del1pETV6repressesR-702-1.51819Pr-136
del13ETV6repressesR-713-1.61645Pr-137
AHNAK2ETV6repressesR-6951.6427Pr-136
PCDH10ETV6repressesR-6951.6427Pr-136
RNASeq_FGFR3_CallETV6repressesR-699-1.76409Pr-99
t(14;16)ETV6repressesR-699-1.76409Pr-99
t(4;14)ETV6repressesR-699-1.76409Pr-99
amp1qETV6repressesR-699-1.76409Pr-99
del13ETV6repressesR-699-1.76409Pr-99
t(4;14)_cytogeneticETV6repressesR-699-1.76409Pr-99
AHNAK2ETV6repressesR-7142.32455Pr-72
ASXL3ETV6repressesR-7142.32455Pr-72
MAGEC1ETV6repressesR-7142.32455Pr-72
RNASeq_FGFR3_CallETV6repressesR-7142.32455Pr-72
t(4;14)ETV6repressesR-7142.32455Pr-72
amp1qETV6repressesR-7142.32455Pr-72
del13ETV6repressesR-7142.32455Pr-72
t(4;14)_cytogeneticETV6repressesR-7142.32455Pr-72
AHNAK2ETV6repressesR-6932.52969Pr-72
PCDH10ETV6repressesR-6932.52969Pr-72
RNASeq_FGFR3_CallETV6repressesR-6932.52969Pr-72
t(4;14)ETV6repressesR-6932.52969Pr-72
del13ETV6repressesR-6932.52969Pr-72
t(4;14)_cytogeneticETV6repressesR-6932.52969Pr-72
RNASeq_FGFR3_CallETV6repressesR-7052.58704Pr-72
t(4;14)ETV6repressesR-7052.58704Pr-72
del13ETV6repressesR-7052.58704Pr-72
t(4;14)_cytogeneticETV6repressesR-7052.58704Pr-72
AHNAK2ETV6repressesR-6962.86125Pr-51

Genes (3)

GPR3

Regulons (8)

R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

ATMETV6repressesR-694-2.92866Pr-118
RNASeq_FGFR3_CallETV6repressesR-694-2.92866Pr-118
RNASeq_MAFB_CallETV6repressesR-694-2.92866Pr-118
t(14;16)ETV6repressesR-694-2.92866Pr-118
t(4;14)ETV6repressesR-694-2.92866Pr-118
amp1qETV6repressesR-694-2.92866Pr-118
del13ETV6repressesR-694-2.92866Pr-118
t(4;14)_cytogeneticETV6repressesR-694-2.92866Pr-118
ATMETV6repressesR-710-3.28784Pr-38
RNASeq_FGFR3_CallETV6repressesR-710-3.28784Pr-38
RNASeq_MAFB_CallETV6repressesR-710-3.28784Pr-38
t(14;16)ETV6repressesR-710-3.28784Pr-38
t(4;14)ETV6repressesR-710-3.28784Pr-38
amp1qETV6repressesR-710-3.28784Pr-38
del13ETV6repressesR-710-3.28784Pr-38
t(4;14)_cytogeneticETV6repressesR-710-3.28784Pr-38
AHNAK2ETV6repressesR-7123.48831Pr-74
AHNAK2ETV6repressesR-7035.54512Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.