Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

TFCP2 - transcription factor CP2

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
7024 ENSG00000135457 TFCP2 F8VWL0

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: TFCP2

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
KIAA1109TFCP2repressesR-1702-0.433807Pr-110
MAXTFCP2repressesR-1702-0.433807Pr-110
t(14;16)_cytogeneticTFCP2repressesR-1702-0.433807Pr-110
RNASeq_MAFA_CallTFCP2repressesR-1698-0.67238Pr-0
RNASeq_MAFA_CallTFCP2repressesR-1699-0.734782Pr-3
RNASeq_MAFB_CallTFCP2repressesR-1699-0.734782Pr-3
KIAA1109TFCP2activatesR-1704-2.40287Pr-39
RNASeq_MAFB_CallTFCP2repressesR-1703-2.82074Pr-125
ROBO1TFCP2repressesR-1703-2.82074Pr-125
MXRA5TFCP2activatesR-1701-3.47247Pr-103

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.