Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

NFATC1 - nuclear factor of activated T cells 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
4772 ENSG00000131196 NFATC1 K7ER53

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: NFATC1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
CACNA1HNFATC1activatesR-21970.666306Pr-29
DNAH5NFATC1activatesR-21970.666306Pr-29
IRF4NFATC1activatesR-21970.666306Pr-29
t(11;14)NFATC1activatesR-21970.666306Pr-29
t(11;14)_cytogeneticNFATC1activatesR-21970.666306Pr-29
CMYA5NFATC1repressesR-2201-0.687031Pr-120
DNAH5NFATC1repressesR-2201-0.687031Pr-120
FAM46CNFATC1repressesR-2201-0.687031Pr-120
IRF4NFATC1repressesR-2201-0.687031Pr-120
t(11;14)NFATC1repressesR-2201-0.687031Pr-120
RNASeq_CCND3_CallNFATC1repressesR-2201-0.687031Pr-120
t(14;16)NFATC1repressesR-2201-0.687031Pr-120
del13NFATC1repressesR-2201-0.687031Pr-120
t(11;14)_cytogeneticNFATC1repressesR-2201-0.687031Pr-120
DNAH5NFATC1activatesR-22050.94749Pr-33
IRF4NFATC1activatesR-22050.94749Pr-33
PRKD2NFATC1activatesR-22050.94749Pr-33
RNASeq_CCND2_CallNFATC1activatesR-22050.94749Pr-33
del13NFATC1activatesR-22050.94749Pr-33
DNAH5NFATC1activatesR-2207-1.00385Pr-15
FAT3NFATC1activatesR-2207-1.00385Pr-15
FBN2NFATC1activatesR-2207-1.00385Pr-15
LRP2NFATC1activatesR-2207-1.00385Pr-15
MAXNFATC1activatesR-2207-1.00385Pr-15
NRASNFATC1activatesR-2207-1.00385Pr-15
PKHD1L1NFATC1activatesR-2207-1.00385Pr-15
PRKD2NFATC1activatesR-2207-1.00385Pr-15
t(11;14)NFATC1activatesR-2207-1.00385Pr-15
RNASeq_CCND2_CallNFATC1activatesR-2207-1.00385Pr-15
RNASeq_CCND3_CallNFATC1activatesR-2207-1.00385Pr-15
RNASeq_MAFA_CallNFATC1activatesR-2207-1.00385Pr-15
ROBO1NFATC1activatesR-2207-1.00385Pr-15
del13NFATC1activatesR-2207-1.00385Pr-15
t(11;14)_cytogeneticNFATC1activatesR-2207-1.00385Pr-15
IRF4NFATC1activatesR-22061.13365Pr-0
NRASNFATC1activatesR-22061.13365Pr-0
t(11;14)NFATC1activatesR-22061.13365Pr-0
RNASeq_CCND2_CallNFATC1activatesR-22061.13365Pr-0
RNASeq_MAFA_CallNFATC1activatesR-22061.13365Pr-0
t(14;16)NFATC1activatesR-22061.13365Pr-0
del13NFATC1activatesR-22061.13365Pr-0
CMYA5NFATC1activatesR-2204-1.15799Pr-10
DNAH5NFATC1activatesR-2204-1.15799Pr-10
FAT3NFATC1activatesR-2204-1.15799Pr-10
IRF4NFATC1activatesR-2204-1.15799Pr-10
LRP2NFATC1activatesR-2204-1.15799Pr-10
PKHD1L1NFATC1activatesR-2204-1.15799Pr-10
t(11;14)NFATC1activatesR-2204-1.15799Pr-10
RNASeq_CCND3_CallNFATC1activatesR-2204-1.15799Pr-10
RNASeq_MAFA_CallNFATC1activatesR-2204-1.15799Pr-10
t(11;14)_cytogeneticNFATC1activatesR-2204-1.15799Pr-10
t(11;14)NFATC1repressesR-22001.67761Pr-133
t(14;16)NFATC1repressesR-22001.67761Pr-133
del13NFATC1repressesR-22001.67761Pr-133
CMYA5NFATC1activatesR-2202-2.7244Pr-19
CYLDNFATC1activatesR-2202-2.7244Pr-19
DNAH5NFATC1activatesR-2202-2.7244Pr-19
FAT3NFATC1activatesR-2202-2.7244Pr-19
MAXNFATC1activatesR-2202-2.7244Pr-19
PKHD1L1NFATC1activatesR-2202-2.7244Pr-19
RNASeq_CCND2_CallNFATC1activatesR-2202-2.7244Pr-19
FAT3NFATC1activatesR-2198-2.73148Pr-11
NRASNFATC1activatesR-2198-2.73148Pr-11
t(14;16)NFATC1activatesR-2198-2.73148Pr-11
ZNF208NFATC1activatesR-2198-2.73148Pr-11
del13NFATC1activatesR-2198-2.73148Pr-11
MAXNFATC1repressesR-22033.03435Pr-127
DNAH5NFATC1activatesR-2199-5.63196Pr-135
PRKD2NFATC1activatesR-2199-5.63196Pr-135
t(11;14)NFATC1activatesR-2199-5.63196Pr-135
RNASeq_MAFA_CallNFATC1activatesR-2199-5.63196Pr-135
ZNF208NFATC1activatesR-2199-5.63196Pr-135
t(11;14)_cytogeneticNFATC1activatesR-2199-5.63196Pr-135

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.