Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

NFKB1 - nuclear factor kappa B subunit 1

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
4790 ENSG00000109320 NFKB1 A0A494C1E9

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: NFKB1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
AHNAK2NFKB1repressesR-1579-0.260085Pr-137
DCHS1NFKB1repressesR-1579-0.260085Pr-137
DIS3NFKB1repressesR-1579-0.260085Pr-137
FAM46CNFKB1repressesR-1579-0.260085Pr-137
MAXNFKB1repressesR-1579-0.260085Pr-137
PTPRDNFKB1repressesR-1579-0.260085Pr-137
RNASeq_CCND2_CallNFKB1repressesR-1579-0.260085Pr-137
RNASeq_FGFR3_CallNFKB1repressesR-1579-0.260085Pr-137
t(4;14)NFKB1repressesR-1579-0.260085Pr-137
SVILNFKB1repressesR-1579-0.260085Pr-137
ZFHX3NFKB1repressesR-1579-0.260085Pr-137
t(4;14)_cytogeneticNFKB1repressesR-1579-0.260085Pr-137
FAT3NFKB1activatesR-15860.40155Pr-2
SVILNFKB1activatesR-15860.40155Pr-2
ZFHX3NFKB1activatesR-15860.40155Pr-2
PCDH10NFKB1activatesR-15840.405223Pr-7
AHNAK2NFKB1activatesR-1572-0.445091Pr-0
FAT3NFKB1activatesR-1572-0.445091Pr-0
MACF1NFKB1activatesR-1572-0.445091Pr-0
MAGI1NFKB1activatesR-1572-0.445091Pr-0
MYO10NFKB1activatesR-1572-0.445091Pr-0
PCDH10NFKB1activatesR-1572-0.445091Pr-0
PTPRDNFKB1activatesR-1572-0.445091Pr-0
RNASeq_CCND2_CallNFKB1activatesR-1572-0.445091Pr-0
TACC2NFKB1activatesR-1572-0.445091Pr-0
AHNAK2NFKB1activatesR-1574-0.538784Pr-2
FAT3NFKB1activatesR-1574-0.538784Pr-2
MACF1NFKB1activatesR-1574-0.538784Pr-2
PCDH10NFKB1activatesR-1574-0.538784Pr-2
RNASeq_MAFB_CallNFKB1activatesR-1574-0.538784Pr-2
TACC2NFKB1activatesR-1574-0.538784Pr-2
TACC2NFKB1repressesR-1591-0.58346Pr-117
AHNAK2NFKB1activatesR-15770.685997Pr-124
MACF1NFKB1activatesR-15770.685997Pr-124
PCDH10NFKB1activatesR-15770.685997Pr-124
BAI3NFKB1repressesR-1578-0.969867Pr-65
DIS3NFKB1repressesR-1578-0.969867Pr-65
FAT3NFKB1repressesR-1578-0.969867Pr-65
MAXNFKB1repressesR-1578-0.969867Pr-65
MYO10NFKB1repressesR-1578-0.969867Pr-65
SVILNFKB1repressesR-1578-0.969867Pr-65
t(4;14)_cytogeneticNFKB1repressesR-1578-0.969867Pr-65
AHNAK2NFKB1activatesR-1585-1.04936Pr-4
FAT3NFKB1activatesR-1585-1.04936Pr-4
MAXNFKB1activatesR-1585-1.04936Pr-4
PTPRDNFKB1activatesR-1585-1.04936Pr-4
RNASeq_MAFB_CallNFKB1activatesR-1585-1.04936Pr-4
TACC2NFKB1activatesR-1585-1.04936Pr-4
AHNAK2NFKB1activatesR-1583-1.38564Pr-9
DCHS1NFKB1activatesR-1583-1.38564Pr-9
FAT3NFKB1activatesR-1583-1.38564Pr-9
MACF1NFKB1activatesR-1583-1.38564Pr-9
MAGI1NFKB1activatesR-1583-1.38564Pr-9
MAXNFKB1activatesR-1583-1.38564Pr-9
MYO10NFKB1activatesR-1583-1.38564Pr-9
PCDH10NFKB1activatesR-1583-1.38564Pr-9
PTPRDNFKB1activatesR-1583-1.38564Pr-9
RNASeq_CCND2_CallNFKB1activatesR-1583-1.38564Pr-9
RNASeq_FGFR3_CallNFKB1activatesR-1583-1.38564Pr-9
RNASeq_MAFB_CallNFKB1activatesR-1583-1.38564Pr-9
t(4;14)NFKB1activatesR-1583-1.38564Pr-9
TACC2NFKB1activatesR-1583-1.38564Pr-9
ZFHX3NFKB1activatesR-1583-1.38564Pr-9
t(4;14)_cytogeneticNFKB1activatesR-1583-1.38564Pr-9
MAXNFKB1activatesR-1593-1.40749Pr-15
RNASeq_CCND2_CallNFKB1activatesR-1593-1.40749Pr-15
RNASeq_FGFR3_CallNFKB1activatesR-1593-1.40749Pr-15
t(4;14)NFKB1activatesR-1593-1.40749Pr-15
t(4;14)_cytogeneticNFKB1activatesR-1593-1.40749Pr-15
MAGI1NFKB1activatesR-15821.44696Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

MYO10NFKB1activatesR-15821.44696Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

PTPRDNFKB1activatesR-15821.44696Pr-134

Genes (104)

MCTP1, RUVBL1, AMIGO3, HSD11B2, RHOG, FLII, TRIML2, RCC2, RAB39A, SEPHS2, ZNF467, ACBD4, SGSH, SHMT2, TRAPPC6B, C16orf72, EWSR1, SELENOF, CSF1, COPB2, ZFP90, TCN2, TARSL2, LMLN, ZBTB3, ZNF829, LAMP1, POLR3C, SESTD1, DCC, PLEKHG7, DPYD, IDO2, ZNF548, NHLRC3, MSANTD1, ARID2, KIAA0408, ZFP92, PAX5, SRGAP3, GDAP2, PDLIM7, HIST1H4C, ZNF785, ZNF786, KLHDC1, ZNF181, MYO1C, ADH5, SIRPA, HIBCH, QRICH1, ASNA1, SPRED2, HLA-DRB5, NCOA6, IPO9, LRIG2, FOXJ3, INPP5F, SELENOT, SPOUT1, PCMTD2, ZNF805, ASPDH, AKT1S1, ZBTB10, CFI, VGLL3, SCAF8, LAT, REPIN1, FBXO16, HAUS3, PPME1, DDX3X, NPEPL1, PPP3R1, C19orf73, TIAF1, PLCXD2, PISD, ARFGAP3, EIF4EBP3, TICAM2, TTC4, PCDHGA12, KIAA1147, THTPA, ZNF559-ZNF177, VBP1, PITX1, HOXD1

Regulons (119)

R-396, R-2169, R-1655, R-642, R-2117, R-1267, R-2764, R-2601, R-1748, R-1705, R-2634, R-172, R-2508, R-1102, R-1707, R-1656, R-1642, R-109, R-1270, R-1933, R-207, R-454, R-1100, R-2607, R-1875, R-57, R-797, R-108, R-1730, R-1741, R-580, R-2659, R-2763, R-944, R-2160, R-100, R-2180, R-2616, R-1769, R-2996, R-1082, R-2500, R-82, R-1310, R-1008, R-1099, R-2435, R-1641, R-380, R-2224, R-2596, R-1643, R-1158, R-1646, R-205, R-899, R-1077, R-516, R-1765, R-2334, R-1066, R-163, R-1376, R-671, R-1281, R-2502, R-2810, R-1582, R-2082, R-3166, R-1004, R-2888, R-822, R-1737, R-1535, R-2748, R-2332, R-2674, R-2614, R-2682, R-1276, R-1639, R-517, R-1732, R-1011, R-1466, R-289, R-2827, R-675, R-549, R-198, R-2841, R-2825, R-2598, R-1307, R-2902, R-515, R-1676, R-103, R-2742, R-1758, R-2229, R-1652, R-1715, R-1058, R-1644, R-1018, R-1653, R-1416, R-2828, R-2670, R-1528, R-446, R-2687, R-520, R-1108, R-1970, R-2513, R-2272

AHNAK2NFKB1activatesR-1588-1.78822Pr-3
MACF1NFKB1activatesR-1588-1.78822Pr-3
MYO10NFKB1activatesR-1588-1.78822Pr-3
FAT3NFKB1activatesR-1580-1.81925Pr-91
MAXNFKB1activatesR-1580-1.81925Pr-91
RNASeq_FGFR3_CallNFKB1activatesR-1580-1.81925Pr-91
t(4;14)NFKB1activatesR-1580-1.81925Pr-91
t(4;14)_cytogeneticNFKB1activatesR-1580-1.81925Pr-91
RNASeq_FGFR3_CallNFKB1activatesR-1590-1.86695Pr-96
t(4;14)NFKB1activatesR-1590-1.86695Pr-96
t(4;14)_cytogeneticNFKB1activatesR-1590-1.86695Pr-96
AHNAK2NFKB1activatesR-1573-2.35352Pr-4
DCHS1NFKB1activatesR-1573-2.35352Pr-4
DIS3NFKB1activatesR-1573-2.35352Pr-4
FAM46CNFKB1activatesR-1573-2.35352Pr-4
FAT3NFKB1activatesR-1573-2.35352Pr-4
MACF1NFKB1activatesR-1573-2.35352Pr-4
MAXNFKB1activatesR-1573-2.35352Pr-4
MYO10NFKB1activatesR-1573-2.35352Pr-4
PTPRDNFKB1activatesR-1573-2.35352Pr-4
RNASeq_CCND2_CallNFKB1activatesR-1573-2.35352Pr-4
RNASeq_FGFR3_CallNFKB1activatesR-1573-2.35352Pr-4
RNASeq_MAFB_CallNFKB1activatesR-1573-2.35352Pr-4
t(4;14)NFKB1activatesR-1573-2.35352Pr-4
TACC2NFKB1activatesR-1573-2.35352Pr-4
t(4;14)_cytogeneticNFKB1activatesR-1573-2.35352Pr-4
FAT3NFKB1activatesR-1587-2.87374Pr-86
MAXNFKB1activatesR-1587-2.87374Pr-86
PCDH10NFKB1activatesR-1587-2.87374Pr-86
RNASeq_CCND2_CallNFKB1activatesR-1587-2.87374Pr-86
RNASeq_FGFR3_CallNFKB1activatesR-1587-2.87374Pr-86
t(4;14)NFKB1activatesR-1587-2.87374Pr-86
t(4;14)_cytogeneticNFKB1activatesR-1587-2.87374Pr-86
FAT3NFKB1activatesR-1576-2.95247Pr-86
MAXNFKB1activatesR-1576-2.95247Pr-86
RNASeq_FGFR3_CallNFKB1activatesR-1576-2.95247Pr-86
t(4;14)NFKB1activatesR-1576-2.95247Pr-86
AHNAK2NFKB1activatesR-1589-3.21935Pr-3
DIS3NFKB1activatesR-1589-3.21935Pr-3
FAT3NFKB1activatesR-1589-3.21935Pr-3
MAXNFKB1activatesR-1589-3.21935Pr-3
RNASeq_FGFR3_CallNFKB1activatesR-1589-3.21935Pr-3
t(4;14)NFKB1activatesR-1589-3.21935Pr-3
TACC2NFKB1activatesR-1589-3.21935Pr-3
t(4;14)_cytogeneticNFKB1activatesR-1589-3.21935Pr-3
AHNAK2NFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DCHS1NFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

DIS3NFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAM46CNFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

FAT3NFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

MACF1NFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RNASeq_FGFR3_CallNFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

RNASeq_MAFB_CallNFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)NFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

t(4;14)_cytogeneticNFKB1repressesR-15813.67297Pr-69

Genes (1)

KLF13

Regulons (9)

R-3040, R-3188, R-1581, R-88, R-1665, R-334, R-703, R-783, R-2719

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.