Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

DBP - D-box binding PAR bZIP transcription factor

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
1628 ENSG00000105516 DBP M0QXP1

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: DBP

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
FGFR3DBPactivatesR-2956-0.373848Pr-111
t(11;14)DBPactivatesR-2956-0.373848Pr-111
RNASeq_CCND2_CallDBPactivatesR-2956-0.373848Pr-111
RNASeq_FGFR3_CallDBPactivatesR-2956-0.373848Pr-111
t(14;16)DBPactivatesR-2956-0.373848Pr-111
t(4;14)DBPactivatesR-2956-0.373848Pr-111
ROBO2DBPactivatesR-2956-0.373848Pr-111
t(4;14)_cytogeneticDBPactivatesR-2956-0.373848Pr-111
amp1qDBPrepressesR-2951-0.862874Pr-0
FRAS1DBPrepressesR-29530.918338Pr-125
IRF4DBPrepressesR-29530.918338Pr-125
PRKD2DBPrepressesR-29530.918338Pr-125
t(11;14)DBPrepressesR-29530.918338Pr-125
t(4;14)DBPrepressesR-29530.918338Pr-125
IRF4DBPrepressesR-29521.09035Pr-14
t(11;14)DBPrepressesR-29521.09035Pr-14
amp1qDBPrepressesR-29521.09035Pr-14
t(11;14)DBPrepressesR-2955-1.4513Pr-3
RNASeq_FGFR3_CallDBPrepressesR-2955-1.4513Pr-3
t(4;14)DBPrepressesR-2955-1.4513Pr-3
MYCDBPrepressesR-2957-2.39881Pr-30
ROBO1DBPrepressesR-2957-2.39881Pr-30
RNASeq_FGFR3_CallDBPrepressesR-2950-2.4332Pr-4
t(4;14)DBPrepressesR-2950-2.4332Pr-4
amp1qDBPrepressesR-2950-2.4332Pr-4
BRAFDBPrepressesR-29542.60221Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

FLGDBPrepressesR-29542.60221Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

HUWE1DBPrepressesR-29542.60221Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

t(11;14)DBPrepressesR-29542.60221Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

RNASeq_CCND2_CallDBPrepressesR-29542.60221Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

t(14;16)DBPrepressesR-29542.60221Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

amp1qDBPrepressesR-29542.60221Pr-83

Genes (1)

APOBEC3D

Regulons (4)

R-2101, R-2954, R-1662, R-2556

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.