Regulator

Summary of regulator annotations and link-out to annotation databases

Basic gene annotations are collected from Uniprot and displayed with links to original sources. A quick link to explore the genomic context with Uniprot Browser is available.

BRCA1 - BRCA1 DNA repair associated

Uniprot Browser
Entrez IDEnsEMBL IDPreferred NameUniprot ID
672 ENSG00000012048 BRCA1 A0A8V8TPY7

List of causal flows containing the regulator.

Causal Flows are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. In the causal flow, a mutation may causally activate or deactivate a downstream regulator which then might up- down-regulates a regulonthat contains genes with similar expression profiles and binding sites.

Causal Mechanistic Flows for Regulator: BRCA1

MutationRegulatorRoleRegulonCox Hazard RatioTranscriptional Program
TP53BRCA1activatesR-10321.10039Pr-117
t(14;16)_cytogeneticBRCA1activatesR-10321.10039Pr-117
HUWE1BRCA1repressesR-1033-2.58375Pr-12
t(11;14)BRCA1repressesR-1033-2.58375Pr-12
TP53BRCA1repressesR-1033-2.58375Pr-12
t(11;14)_cytogeneticBRCA1repressesR-1033-2.58375Pr-12
DIS3BRCA1activatesR-10312.71498Pr-123
DNAH10BRCA1activatesR-10312.71498Pr-123
FRAS1BRCA1activatesR-10312.71498Pr-123
IRF4BRCA1activatesR-10312.71498Pr-123
LTBBRCA1activatesR-10312.71498Pr-123
PRKD2BRCA1activatesR-10312.71498Pr-123
t(11;14)BRCA1activatesR-10312.71498Pr-123
RNASeq_FGFR3_CallBRCA1activatesR-10312.71498Pr-123
t(4;14)BRCA1activatesR-10312.71498Pr-123
TP53BRCA1activatesR-10312.71498Pr-123
ZNF208BRCA1activatesR-10312.71498Pr-123
amp1qBRCA1activatesR-10312.71498Pr-123
t(11;14)_cytogeneticBRCA1activatesR-10312.71498Pr-123
t(4;14)_cytogeneticBRCA1activatesR-10312.71498Pr-123
DIS3BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

DNAH10BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

FAT3BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

IRF4BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

MACF1BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

PRKD2BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

RNASeq_FGFR3_CallBRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(14;16)BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(4;14)BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

TP53BRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(11;14)_cytogeneticBRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(14;16)_cytogeneticBRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

t(4;14)_cytogeneticBRCA1repressesR-1030-3.4552Pr-26

Genes (2)

TEDC1, ZNF688

Regulons (7)

R-3078, R-1915, R-551, R-2188, R-1030, R-512, R-2604

Regulator Causal Mechanistic Flow Network

Cytoscape network of the regulator, with upstream mutations and downstream regulons.

Influences from mutations (magenta chevrons) to this regulator (blue triangles) and then from the regulator to the downstream regulons (red square) are indicated with colored edges. Red-colored edges denote up-regulation or activation while green colored edges represent down-regulation or repression.