Program

Causal Mechanistic Flows with regulons in program Pr-92

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
ATMup-regulatesSPIBactivatesR-670-0.2684413Pr-92
DNAH10up-regulatesSPIBactivatesR-670-0.2684413Pr-92
FAM46Cdown-regulatesSPIBactivatesR-670-0.2684413Pr-92
NRASdown-regulatesSPIBactivatesR-670-0.2684413Pr-92
PRDM1up-regulatesSPIBactivatesR-670-0.2684413Pr-92
RNASeq_MAFA_Callup-regulatesSPIBactivatesR-670-0.2684413Pr-92
RNASeq_MAFB_Callup-regulatesSPIBactivatesR-670-0.2684413Pr-92
t(14;16)up-regulatesSPIBactivatesR-670-0.2684413Pr-92
del1pup-regulatesSPIBactivatesR-670-0.2684413Pr-92
NRASup-regulatesNR2C2repressesR-1389-0.4015967Pr-92
RNASeq_MAFA_Calldown-regulatesNR2C2repressesR-1389-0.4015967Pr-92
del1pup-regulatesENSG00000179348activatesR-1063-0.4813327Pr-92
RNASeq_FGFR3_Calldown-regulatesRREB1activatesR-2294-0.50208914Pr-92
t(4;14)down-regulatesRREB1activatesR-2294-0.50208914Pr-92
t(4;14)_cytogeneticdown-regulatesRREB1activatesR-2294-0.50208914Pr-92
LRP2down-regulatesENSG00000054598activatesR-1012-0.70750116Pr-92
t(11;14)up-regulatesENSG00000054598activatesR-1012-0.70750116Pr-92
t(14;16)up-regulatesZNF410activatesR-1938-0.8565868Pr-92
del1pup-regulatesZNF410activatesR-1938-0.8565868Pr-92
t(11;14)up-regulatesENSG00000105610activatesR-209-0.8756916Pr-92
RNASeq_FGFR3_Calldown-regulatesENSG00000105610activatesR-209-0.8756916Pr-92
t(4;14)down-regulatesENSG00000105610activatesR-209-0.8756916Pr-92
FGFR3down-regulatesKLF16activatesR-2697-0.8798489Pr-92
PTPRDup-regulatesKLF16activatesR-2697-0.8798489Pr-92
RNASeq_FGFR3_Calldown-regulatesKLF16activatesR-2697-0.8798489Pr-92
t(4;14)down-regulatesKLF16activatesR-2697-0.8798489Pr-92
t(4;14)_cytogeneticdown-regulatesKLF16activatesR-2697-0.8798489Pr-92
IRF4up-regulatesRARAactivatesR-162-1.053111Pr-92
PCDH10down-regulatesRARAactivatesR-162-1.053111Pr-92
t(11;14)up-regulatesRARAactivatesR-162-1.053111Pr-92
t(11;14)_cytogeneticup-regulatesRARAactivatesR-162-1.053111Pr-92

Regulons in program Pr-92

Regulon Cox Hazard Ratio # genes # causal flows
R-670-0.26844139
R-1389-0.40159672
R-1063-0.48133271
R-2294-0.502089143
R-1012-0.707501162
R-1938-0.85658682
R-209-0.87569163
R-2697-0.87984895
R-162-1.0531114

Genes in program Pr-92

EnsEMBL IdEntrez IdPreferred
ENSG00000177868 374969SVBP
ENSG00000179841 9495AKAP5
ENSG00000181035 284439SLC25A42
ENSG00000181374
ENSG00000184508 374659HDDC3
ENSG00000186187 84937ZNRF1
ENSG00000186448 10168ZNF197
ENSG00000186501 84065TMEM222
ENSG00000188938 158293FAM120AOS

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions