Program – Multiple Myeloma Network Portal

Causal Mechanistic Flows with regulons in program Pr-78

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
NEB	down-regulates	ZNF410	represses	R-1941	1.73996	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
IRF4	down-regulates	ESRRA	activates	R-2744	2.16113	7	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(11;14)	down-regulates	ESRRA	activates	R-2744	2.16113	7	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
MYC	up-regulates	ESRRA	activates	R-2744	2.16113	7	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(11;14)_cytogenetic	down-regulates	ESRRA	activates	R-2744	2.16113	7	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
AHNAK2	up-regulates	MYBL2	activates	R-656	3.10274	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(14;16)	up-regulates	MYBL2	activates	R-656	3.10274	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
MYC	up-regulates	MYBL2	activates	R-656	3.10274	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(14;16)_cytogenetic	up-regulates	MYBL2	activates	R-656	3.10274	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
AHNAK2	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
DCHS1	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
PCDH15	down-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
PTPRD	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
RNASeq_FGFR3_Call	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
RNASeq_MAFA_Call	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
RNASeq_MAFB_Call	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(14;16)	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(4;14)	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
ROBO2	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
TRIO	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
ZNF462	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
amp1q	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(14;16)_cytogenetic	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(4;14)_cytogenetic	up-regulates	SP1	activates	R-2715	3.33045	32	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
FLG	up-regulates	MYC	activates	R-2072	3.75576	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
PCDH15	down-regulates	MYC	activates	R-2072	3.75576	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(11;14)	down-regulates	MYC	activates	R-2072	3.75576	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
MYC	up-regulates	MYC	activates	R-2072	3.75576	6	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
MUC12	up-regulates	FOX3A	activates	R-1512	3.9913	11	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(11;14)	down-regulates	FOX3A	activates	R-1512	3.9913	11	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
RNASeq_FGFR3_Call	up-regulates	FOX3A	activates	R-1512	3.9913	11	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
RNASeq_MAFA_Call	up-regulates	FOX3A	activates	R-1512	3.9913	11	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(14;16)	up-regulates	FOX3A	activates	R-1512	3.9913	11	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(4;14)	up-regulates	FOX3A	activates	R-1512	3.9913	11	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
amp1q	up-regulates	FOX3A	activates	R-1512	3.9913	11	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512
t(11;14)_cytogenetic	down-regulates	FOX3A	activates	R-1512	3.9913	11	Pr-78 Genes (2) STIMATE, DDOST Regulons (6) R-1941, R-2744, R-656, R-2715, R-2072, R-1512

Regulons in program Pr-78

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-1941	1.73996	6	1
R-2744	2.16113	7	4
R-656	3.10274	6	4
R-2715	3.33045	32	15
R-2072	3.75576	6	4
R-1512	3.9913	11	8

Genes in program Pr-78

EnsEMBL Id	Entrez Id	Preferred
ENSG00000213533	375346	STIMATE
ENSG00000244038	1650	DDOST

Pr-78

Program 78

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Program Survival Plots