Program

Causal Mechanistic Flows with regulons in program Pr-64

MutationRoleRegulatorRoleRegulonHazard Ratio# regulon genesTranscriptional Program
AHNAK2down-regulatesELF1activatesR-2979-0.30075318Pr-64
DSTdown-regulatesELF1activatesR-2979-0.30075318Pr-64
PCDH10down-regulatesELF1activatesR-2979-0.30075318Pr-64
t(11;14)up-regulatesELF1activatesR-2979-0.30075318Pr-64
t(11;14)_cytogeneticup-regulatesELF1activatesR-2979-0.30075318Pr-64
LRP2down-regulatesSPI1activatesR-2609-0.73774425Pr-64
t(11;14)up-regulatesSPI1activatesR-2609-0.73774425Pr-64
RNASeq_FGFR3_Calldown-regulatesSPI1activatesR-2609-0.73774425Pr-64
t(4;14)down-regulatesSPI1activatesR-2609-0.73774425Pr-64
CYLDup-regulatesETS1activatesR-7-0.820937Pr-64
FAT2up-regulatesETS1activatesR-7-0.820937Pr-64
FGFR3down-regulatesETS1activatesR-7-0.820937Pr-64
MAXdown-regulatesETS1activatesR-7-0.820937Pr-64
NRASdown-regulatesETS1activatesR-7-0.820937Pr-64
PRKD2down-regulatesETS1activatesR-7-0.820937Pr-64
RNASeq_FGFR3_Calldown-regulatesETS1activatesR-7-0.820937Pr-64
RNASeq_MAFA_Callup-regulatesETS1activatesR-7-0.820937Pr-64
RNASeq_MAFB_Callup-regulatesETS1activatesR-7-0.820937Pr-64
t(14;16)up-regulatesETS1activatesR-7-0.820937Pr-64
t(4;14)down-regulatesETS1activatesR-7-0.820937Pr-64
ZNF208down-regulatesETS1activatesR-7-0.820937Pr-64
t(4;14)_cytogeneticdown-regulatesETS1activatesR-7-0.820937Pr-64
DSTdown-regulatesSATB1activatesR-1073-0.97707917Pr-64
AHNAK2down-regulatesFOXO1activatesR-1404-0.9904923Pr-64
t(11;14)up-regulatesFOXO1activatesR-1404-0.9904923Pr-64
CYLDup-regulatesETS1activatesR-1-1.6191317Pr-64
MAXdown-regulatesETS1activatesR-1-1.6191317Pr-64
NFKB2up-regulatesETS1activatesR-1-1.6191317Pr-64
NRASdown-regulatesETS1activatesR-1-1.6191317Pr-64
PRKD2down-regulatesETS1activatesR-1-1.6191317Pr-64
RNASeq_CCND2_Calldown-regulatesETS1activatesR-1-1.6191317Pr-64
RNASeq_FGFR3_Calldown-regulatesETS1activatesR-1-1.6191317Pr-64
RNASeq_MAFB_Callup-regulatesETS1activatesR-1-1.6191317Pr-64
MYCdown-regulatesETS1activatesR-1-1.6191317Pr-64
t(4;14)down-regulatesETS1activatesR-1-1.6191317Pr-64
ZNF208down-regulatesETS1activatesR-1-1.6191317Pr-64
FAM46Cdown-regulatesTFEBactivatesR-887-2.839767Pr-64
LRP1Bdown-regulatesTFEBactivatesR-887-2.839767Pr-64
LRP2down-regulatesTFEBactivatesR-887-2.839767Pr-64
MUC12down-regulatesTFEBactivatesR-887-2.839767Pr-64
NRASdown-regulatesTFEBactivatesR-887-2.839767Pr-64
t(11;14)up-regulatesTFEBactivatesR-887-2.839767Pr-64
MYCdown-regulatesTFEBactivatesR-887-2.839767Pr-64
t(11;14)_cytogeneticup-regulatesTFEBactivatesR-887-2.839767Pr-64
MXRA5down-regulatesUSF1activatesR-1856-3.727129Pr-64
NFKB2up-regulatesUSF1activatesR-1856-3.727129Pr-64
NRASdown-regulatesUSF1activatesR-1856-3.727129Pr-64
RNASeq_CCND3_Callup-regulatesUSF1activatesR-1856-3.727129Pr-64
MYCdown-regulatesUSF1activatesR-1856-3.727129Pr-64
SVEP1down-regulatesUSF1activatesR-1856-3.727129Pr-64
t(11;14)_cytogeneticup-regulatesUSF1activatesR-1856-3.727129Pr-64

Regulons in program Pr-64

Regulon Cox Hazard Ratio # genes # causal flows
R-2979-0.300753185
R-2609-0.737744254
R-7-0.82093713
R-1073-0.977079171
R-1404-0.99049232
R-1-1.619131711
R-887-2.8397678
R-1856-3.7271297

Genes in program Pr-64

EnsEMBL IdEntrez IdPreferred
ENSG00000178425 221294NT5DC1
ENSG00000184831 79135APOO
ENSG00000185722 51479ANKFY1
ENSG00000187790 57697FANCM
ENSG00000188060 115273RAB42
ENSG00000204947 155054ZNF425

Program Survival Plots

Kaplan-Meier curves demonstrating the sub-stratification of clinical subtypes based upon the network activity of the most predictive individual or pair of genes as determined by the LASSO predictions