Program – Multiple Myeloma Network Portal

Causal Mechanistic Flows with regulons in program Pr-51

Mutation	Role	Regulator	Role	Regulon	Hazard Ratio	# regulon genes	Transcriptional Program
DIS3	up-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
FAM46C	down-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
FGFR3	up-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
LTB	up-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
t(11;14)	up-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
RNASeq_FGFR3_Call	up-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
t(4;14)	up-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
del13	up-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
t(4;14)_cytogenetic	up-regulates	ZFX	activates	R-1926	0.529957	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
t(11;14)	up-regulates	ENSG00000245848	activates	R-1648	2.24486	14	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
MYC	down-regulates	ENSG00000245848	activates	R-1648	2.24486	14	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
CYLD	down-regulates	ZNF691	activates	R-3005	2.31507	10	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
MAX	up-regulates	ZNF691	activates	R-3005	2.31507	10	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
PRKD2	up-regulates	ZNF691	activates	R-3005	2.31507	10	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
AHNAK2	down-regulates	ETV6	represses	R-696	2.86125	17	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
DCHS1	up-regulates	ZNF143	activates	R-2308	2.93506	18	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
FAT3	up-regulates	ZNF143	activates	R-2308	2.93506	18	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
NRAS	down-regulates	ZNF143	activates	R-2308	2.93506	18	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
ROBO1	down-regulates	ZNF143	activates	R-2308	2.93506	18	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
t(14;16)_cytogenetic	up-regulates	ZNF143	activates	R-2308	2.93506	18	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
AHNAK2	down-regulates	FOXK1	represses	R-1210	3.29949	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
DCHS1	down-regulates	FOXK1	represses	R-1210	3.29949	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
PTPRD	down-regulates	FOXK1	represses	R-1210	3.29949	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
RNASeq_MAFA_Call	down-regulates	FOXK1	represses	R-1210	3.29949	7	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
LRP1B	down-regulates	TFEB	represses	R-888	3.89335	6	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
MUC12	down-regulates	TFEB	represses	R-888	3.89335	6	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
PCLO	down-regulates	TFEB	represses	R-888	3.89335	6	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
t(14;16)_cytogenetic	down-regulates	TFEB	represses	R-888	3.89335	6	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531
t(14;16)	down-regulates	PLAG1	activates	R-1531	5.07387	6	Pr-51 Genes (3) GPR3 Regulons (8) R-1926, R-1648, R-3005, R-696, R-2308, R-1210, R-888, R-1531

Regulons in program Pr-51

Regulon	Cox Hazard Ratio	# genes	# causal flows
R-1926	0.529957	7	9
R-1648	2.24486	14	2
R-3005	2.31507	10	3
R-696	2.86125	17	1
R-2308	2.93506	18	5
R-1210	3.29949	7	4
R-888	3.89335	6	4
R-1531	5.07387	6	1

Genes in program Pr-51

EnsEMBL Id	Entrez Id	Preferred
ENSG00000181773	2827	GPR3
ENSG00000253293
ENSG00000257017

Pr-51

Program 51

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Regulons (8)

Causal Mechanistic Flows with regulons in program Pr-51

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Regulons in program Pr-51

Genes in program Pr-51

Program Survival Plots